Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Ketoisovalerate oxidoreductase subunit VorD
O-(5'-phospho-DNA)-tyrosine intermediate
SAM-dependent methyltransferase TRM5/TYW2-type
tRNA (cytosine(49)-C(5))-methyltransferase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Membrane protein 6-pyruvoyl-tetrahydropterin synthase-related
Glycosyltransferase subfamily 4-like N-terminal
Probable cobalamin biosynthesis protein CobD
Damage-control phosphatase ARMT1-like metal-binding
Probable Brix domain-containing ribosomal biogenesis protein
Trk system potassium uptake protein TrkA homolog
Na+/H+ antiporter MnhB subunit-related protein
DNA double-strand break repair Rad50 ATPase
Probable threonylcarbamoyladenosine tRNA methylthiotransferase
Alpha-D-phosphohexomutase alpha/beta/alpha
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
Major facilitator superfamily (MFS) profile
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
DNA-directed RNA polymerase subunit Rpo1C
Bacterial type II secretion system protein E
Putative 1-aminocyclopropane-1-carboxylate deaminase
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Signal recognition particle 54 kDa protein
SUF system FeS cluster assembly SufBD N-terminal
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase
Translation initiation factor 2 subunit beta
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ribosome maturation protein SDO1 homolog
Lack of tRNA(Phe):m1G methyltransferase activity, but does not affect tRNA(Phe):imG2 methyltransferase activity.
tRNA (guanine(37)-N1)/4-demethylwyosine(37)-methyltransferase Taw22
O-(3'-phospho-DNA)-tyrosine intermediate
Probable glycine cleavage system H protein
Adenosylcobinamide-GDP ribazoletransferase
Aldehyde ferredoxin oxidoreductase N-terminal
Putative methylthioribose-1-phosphate isomerase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Uncharacterized HTH-type transcriptional regulator PYRAB00690
Polymerase/histidinol phosphatase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Involved in ionization of N3 of dUMP, leading to its activation
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Uncharacterized ATP-binding protein PYRAB09480
Polyribonucleotide 5'-hydroxyl-kinase PYRAB01840
Pyruvate/ketoisovalerate oxidoreductases common subunit gamma
N-(5'-phosphoribosyl)anthranilate isomerase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
Pyridoxal 5'-phosphate synthase subunit PdxT
Polysaccharide biosynthesis protein C-terminal
Putative translation initiation factor eIF-2B subunit 2-like
Putative ABC transporter ATP-binding protein PYRAB03730
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Schiff-base intermediate with dihydroxyacetone-P
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA (guanine(26)-N(2))-dimethyltransferase
DNA-directed RNA polymerase subunit Rpo10
Ribosomal RNA small subunit methyltransferase Nep1
UPF0173 metal-dependent hydrolase PYRAB05000
Probable glycine dehydrogenase (decarboxylating) subunit 1
Removed in mature form; by autocatalysis
Docks into pockets in the proteasome alpha-ring to cause gate opening
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ATP-dependent DNA helicase RecG C-terminal
DNA-directed RNA polymerase subunit Rpo5
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 1
Zn-dependent metallo-hydrolase RNA specificity
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Alanyl-transfer RNA synthetases family profile
Abolishes iron binding. Reduces the tRNA modification activity of the KEOPS complex by 90%.
Completely impairs the tRNA modification activity of the KEOPS complex. Does not impair ATPase activity of the complex.
Loss of iron, but no change in DNA-binding.
tRNA N6-adenosine threonylcarbamoyltransferase
3-isopropylmalate dehydratase large subunit 1
Putative transcriptional regulatory protein PYRAB13000
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Plays an important role in substrate specificity
tRNA (uracil(54)-C(5))-methyltransferase
Peptidase S9 prolyl oligopeptidase catalytic
Methylene-tetrahydrofolate reductase C-terminal
Translation initiation factor 2 subunit gamma
3-methyl-2-oxobutanoate hydroxymethyltransferase
Putative [LysW]-lysine/[LysW]-ornithine hydrolase
Protein-L-isoaspartate O-methyltransferase
Molybdate/tungstate transport system permease protein WtpB
Pyruvate/ketoisovalerate oxidoreductase catalytic
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Dinitrogenase iron-molybdenum cofactor biosynthesis
Sodium/calcium exchanger membrane region
V-type ATP synthase alpha chain, 1st part
V-type ATP synthase alpha chain, 2nd part
Peptidase M1 membrane alanine aminopeptidase
Tungsten-containing aldehyde ferredoxin oxidoreductase
Indolepyruvate oxidoreductase subunit IorA
Molybdopterin synthase catalytic subunit
Formate-dependent phosphoribosylglycinamide formyltransferase
Uncharacterized HTH-type transcriptional regulator PYRAB16920
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Pyruvoyl-dependent arginine decarboxylase subunit alpha
Pyruvoyl-dependent arginine decarboxylase subunit beta
Does not affect ring assembly, but abolishes RNA degradation; when associated with E-89.
Does not affect ring assembly, but abolishes RNA degradation; when associated with E-91.
Probable chemoreceptor glutamine deamidase CheD
Phosphoribosylformylglycinamidine synthase subunit PurL
Indolepyruvate oxidoreductase subunit IorB
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Cyclic 2,3-diphosphoglycerate synthetase
Anthranilate synthase component I N-terminal
Phosphoadenosine phosphosulphate reductase
Aspartate/homoserine dehydrogenase NAD-binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Tryptophan synthase beta chain-like PALP
Type I restriction modification DNA specificity
Isolated domain does not deacylate mischarged L-seryl-tRNA(Thr).
Isolated domain has decreased to no deacylation of mischarged L-seryl-tRNA(Thr). Deacylates correctly charged glycyl-tRNA(Gly).
Isolated domain has nearly wild-type deacylation of mischarged L-seryl-tRNA(Thr), no longer binds L-Ser or L-Cys. No activity on threonyl-tRNA(Thr). Same results; when associated with A-134.
Isolated domain has nearly wild-type deacylation of mischarged L-seryl-tRNA(Thr). Later shown not to deacylate L-seryl-tRNA(Thr), no activity on L-threonyl-tRNA(Thr).
Isolated domain has nearly wild-type deacylation of mischarged L-seryl-tRNA(Thr). No activity on L-threonyl-tRNA(Thr). Same results; when associated with A-120.
Phosphoribosylformylglycinamidine synthase subunit PurQ
Translation initiation factor 2 subunit alpha
Formylmethanofuran dehydrogenase subunit E
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glycoside hydrolase family 57 N-terminal
DNA-directed RNA polymerase subunit Rpo11
Uncharacterized HTH-type transcriptional regulator PYRAB09690
Molybdate/tungstate-binding protein WtpA
Phosphatidic acid phosphatase type 2/haloperoxidase
Transcription regulator AsnC/Lrp ligand binding
23S rRNA (uracil(747)-C(5))-methyltransferase
Probable molybdenum cofactor guanylyltransferase
3-isopropylmalate dehydratase small subunit 1
tRNA (pseudouridine(54)-N(1))-methyltransferase
Putative HTH-type transcriptional regulatory protein PYRAB03670
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Aminoacyl-transfer RNA synthetases class-II family profile
Phenylalanine--tRNA ligase alpha subunit
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
3-isopropylmalate dehydratase large subunit 2
Molybdate/tungstate import ATP-binding protein WtpC
Putative ABC transporter ATP-binding protein PYRAB01300
tRNA (cytidine(56)-2'-O)-methyltransferase
Completely abolishes ATPase activity of the KEOPS complex and completely impairs the tRNA modification activity of the complex.
Mannose-6-phosphate isomerase type II C-terminal
DNA repair and recombination protein RadA
Uncharacterized DapA-like lyase PYRAB12600
DNA-directed RNA polymerase subunit Rpo6
Digeranylgeranylglyceryl phosphate synthase
Probable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
Water stress and hypersensitive response
Small zinc finger protein HVO-2753-like zinc-binding pocket
DNA-directed RNA polymerase subunit Rpo12
3-isopropylmalate dehydratase small subunit 2
DNA polymerase II large subunit, 1st part
DNA polymerase II large subunit, 2nd part
Nascent polypeptide-associated complex protein
Methylated-DNA--protein-cysteine methyltransferase
Decreases efficiency of the dimethylation reaction.
Decreases stability of TrmI at extreme temperatures; when associated with S-196.
Decreases stability of TrmI at extreme temperatures; when associated with S-233.
tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI
Putative [LysW]-L-2-aminoadipate/[LysW]-L-glutamate phosphate reductase
DNA mismatch repair proteins mutS family
Signal recognition particle 19 kDa protein
tRNA(Met) cytidine acetyltransferase TmcA
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Cysteine sulfenic acid (-SOH) intermediate
tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase 2
Phosphate import ATP-binding protein PstB
Protein-glutamate methylesterase/protein-glutamine glutaminase
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
Stabilizes the phosphate intermediate; shared with dimeric partner
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
rRNA small subunit methyltransferase F RNA-binding PUA-like
Putative [LysW]-aminoadipate semialdehyde/glutamate semialdehyde transaminase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Nicotinamide-nucleotide adenylyltransferase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
GMP synthase [glutamine-hydrolyzing] subunit B
Glutamyl-tRNA(Gln) amidotransferase subunit E
Ketoisovalerate oxidoreductase subunit VorB
Probable ribosomal RNA small subunit methyltransferase A
Uncharacterized ATP-binding protein PYRAB06260
Digeranylgeranylglycerophospholipid reductase
GMP synthase [glutamine-hydrolyzing] subunit A
Glutamyl-tRNA(Gln) amidotransferase subunit D
Phosphoribosylformylglycinamidine cyclo-ligase
Uncharacterized HTH-type transcriptional regulator PYRAB04820
Nicotinate phosphoribosyltransferase C-terminal
ADP-dependent glucose/glucosamine kinase
Does not affect ring assembly, but decreases RNA degradation.
DNA repair and recombination protein RadB
Uncharacterized HTH-type transcriptional regulator PYRAB00550
Aspartate carbamoyltransferase regulatory chain
Glyceraldehyde-3-phosphate dehydrogenase
Pyridoxal 5'-phosphate synthase subunit PdxS
Schiff-base intermediate with D-ribose 5-phosphate
Geranylgeranylglyceryl phosphate synthase
6-hydroxymethylpterin diphosphokinase MptE-like
Probable glycine dehydrogenase (decarboxylating) subunit 2
tRNA (guanine(37)-N1)-methyltransferase Trm5b
Glycerol-1-phosphate dehydrogenase [NAD(P)+]