Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alpha-glycerophosphate oxidase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Major facilitator superfamily (MFS) profile
Sporulation transcription regulator WhiA N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Ribose-phosphate pyrophosphokinase N-terminal
Penicillin-binding protein transpeptidase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
DNA primase/polymerase bifunctional N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyridine nucleotide-disulphide oxidoreductase dimerisation
S-adenosyl-L-homocysteine hydrolase NAD binding
Endoribonuclease L-PSP/chorismate mutase-like
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Trigger factor ribosome-binding bacterial
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cytochrome oxidase subunit II copper A binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Transcription regulator AsnC/Lrp ligand binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
SGNH hydrolase-type esterase domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Important for beta-aspartyl-AMP intermediate formation
Helix-hairpin-helix DNA-binding motif class 1
Glycine cleavage T-protein C-terminal barrel
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Methionyl-tRNA synthetase anticodon-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Aminoacyl-transfer RNA synthetases class-II family profile
Peptidase M14 carboxypeptidase A domain-containing protein
Solute-binding protein family 3/N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Putative glycogen debranching enzyme N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Putative regulatory protein FmdB Zinc ribbon
Bacterial bifunctional deaminase-reductase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cell envelope-related transcriptional attenuator
Glucose-methanol-choline oxidoreductase C-terminal
Phosphomannose isomerase type I catalytic
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Prokaryotic-type class I peptide chain release factors
Putative Flp pilus-assembly TadG-like N-terminal
Septum formation-related domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Survival protein SurE-like phosphatase/nucleotidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
RNA 2-O ribose methyltransferase substrate binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Cation-transporting P-type ATPase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Adaptive response protein AidB N-terminal
Glycosyl transferase family 3 N-terminal
Histidine-specific methyltransferase SAM-dependent
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Sodium/calcium exchanger membrane region
Cytochrome C biogenesis protein transmembrane
Acetylserotonin O-methyltransferase dimerisation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptide methionine sulphoxide reductase MsrA
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pseudouridine synthase I TruA alpha/beta
Aconitase A/isopropylmalate dehydratase small subunit swivel
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Cell wall-active antibiotics response LiaF-like C-terminal
L-seryl-tRNA selenium transferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Peptidase S9 prolyl oligopeptidase catalytic
Membrane insertase YidC/Oxa/ALB C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Acyltransferase MbtK/IucB-like conserved
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Tryptophan synthase beta chain-like PALP
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Resolvase/invertase-type recombinase catalytic
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Periplasmic binding protein domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
CobB/CobQ-like glutamine amidotransferase
Carbohydrate binding module xylan-binding
6-phosphogluconate dehydrogenase C-terminal
Saccharopine dehydrogenase-like C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyridoxamine 5'-phosphate oxidase putative
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Plays an important role in substrate specificity
Polysaccharide biosynthesis protein CapD-like
PhoD-like phosphatase metallophosphatase
Glycoside hydrolase family 31 N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Polysaccharide chain length determinant N-terminal
Positions MEP for the nucleophilic attack
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Anthranilate synthase component I N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Polysaccharide biosynthesis protein C-terminal
Carboxypeptidase regulatory-like domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Methylguanine DNA methyltransferase ribonuclease-like
Membrane fusion protein biotin-lipoyl like
Translation elongation factor P/YeiP central
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Peptidase M43 pregnancy-associated plasma-A
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Contractile injection system tube protein N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Polymerase/histidinol phosphatase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Alanyl-transfer RNA synthetases family profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
NIF system FeS cluster assembly NifU N-terminal
TetR transcriptional regulator Rv1219c-like C-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Chromosomal replication initiator DnaA C-terminal
Large ribosomal subunit protein uL6 alpha-beta
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Reversibly protonated during proton transport
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Peptidase M1 membrane alanine aminopeptidase
N6 adenine-specific DNA methyltransferase N-terminal
Peptidase C39-like domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glucosamine/galactosamine-6-phosphate isomerase
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Phosphoadenosine phosphosulphate reductase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
6-phosphogluconate dehydrogenase NADP-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Arabinogalactan endo-beta-1,4-galactanase
Type IV secretion system coupling protein TraD DNA-binding
Essential for prephenate dehydratase activity
Proton acceptor; for glutaminase activity
DnaJ homologue subfamily C member 28 conserved
Bacterial type II secretion system protein E
Schiff-base intermediate with D-ribose 5-phosphate
DNA-directed RNA polymerase RpoA/D/Rpb3-type
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Erythromycin biosynthesis protein CIII-like central
Peptidoglycan recognition protein family
O-(3'-phospho-DNA)-tyrosine intermediate
2-oxoacid dehydrogenase acyltransferase catalytic
AMP-activated protein kinase glycogen-binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Lantibiotic biosynthesis protein dehydration
Large ribosomal subunit protein uL15/eL18
Glutathionylspermidine synthase pre-ATP-grasp-like
Could play a key role in the communication between the regulatory and the substrate sites
Myo-inositol-1-phosphate synthase GAPDH-like
Glucose/Sorbosone dehydrogenase domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Ionotropic glutamate receptor C-terminal
Transposase IS116/IS110/IS902 C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
DNA replication/recombination mediator RecO N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
RlpA-like protein double-psi beta-barrel
Ribosomal RNA adenine methylase transferase N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Interaction with polymerase core subunit RpoC
Putative oxidoreductase/dehydrogenase Rossmann-like
Mannose-6-phosphate isomerase type II C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Gly-cisPro motif, important for rejection of L-amino acids
Actinobacteria/chloroflexi VLRF1 release factor
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)