TonB-dependent receptor-like beta-barrel
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Sodium/calcium exchanger membrane region
Polysaccharide chain length determinant N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Positions MEP for the nucleophilic attack
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial type II secretion system protein E
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Gamma-butyrobetaine hydroxylase-like N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Heme-copper oxidase subunit III family profile
DNA-directed DNA polymerase family A palm
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Type II secretion system protein GspG C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Small ribosomal subunit protein uS4 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Tryptophan synthase beta chain-like PALP
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
O-(5'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Intracellular sulfur oxidation DsrE/DsrF family protein
Moybdenum cofactor oxidoreductase dimerisation
Glycosyl transferase family 3 N-terminal
Prokaryotic-type class I peptide chain release factors
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Plays an important role in substrate specificity
Alpha-D-phosphohexomutase alpha/beta/alpha
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Chromosomal replication initiator protein DnaA
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Membrane insertase YidC/Oxa/ALB C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Alanyl-transfer RNA synthetases family profile
Important for interaction with partner proteins
Transposase IS116/IS110/IS902 C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Proton acceptor; for glutaminase activity
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
O-(3'-phospho-DNA)-tyrosine intermediate
Thiolase-like protein type 1 additional C-terminal
Essential for prephenate dehydratase activity
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
RNA polymerase sigma factor 70 region 4 type 2
Glycosyl-hydrolase 97 C-terminal oligomerisation
Polymerase/histidinol phosphatase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Translation elongation factor P/YeiP central
ASP external chaperone domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Major facilitator superfamily (MFS) profile
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Aminoacyl-transfer RNA synthetases class-II family profile
Electron transfer via tryptophanyl radical
Type II secretion system protein GspI C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
S-adenosyl-L-homocysteine hydrolase NAD binding
Inner membrane protein YgaP-like transmembrane
Glycosyltransferase subfamily 4-like N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Peptide methionine sulphoxide reductase MsrA
Flagellar basal body rod protein N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Large ribosomal subunit protein uL6 alpha-beta
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Release factor glutamine methyltransferase N-terminal
Large ribosomal subunit protein uL15/eL18
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Reversibly protonated during proton transport
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Nitrite/Sulfite reductase ferredoxin-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Pseudouridine synthase I TruA alpha/beta
Exonuclease VII large subunit C-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interacts with tRNA; defines subfamily-specific binding signature
Sodium symporter small subunit predicted
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-106)
Outer-membrane lipoprotein carrier protein
Outer membrane protein beta-barrel domain-containing protein
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
DNA polymerase III subunit delta C-terminal
N-end rule aminoacyl transferase C-terminal
Outer membrane protein assembly factor BamA
Putative regulatory protein FmdB Zinc ribbon
Urease accessory protein UreH-like transmembrane
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Aconitase A/isopropylmalate dehydratase small subunit swivel
Prepilin type IV endopeptidase peptidase
DNA replication/recombination mediator RecO N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cytochrome c-type biogenesis protein CcmF C-terminal
Polysaccharide biosynthesis protein CapD-like
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ribose-phosphate pyrophosphokinase N-terminal
MucB/RseB-like sigma(E) regulatory protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Penicillin-binding protein transpeptidase
Thiol:disulfide interchange protein DsbD N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
BREX system Lon protease-like BrxL N-terminal
Interaction with polymerase core subunit RpoC
Thymidylate synthase/dCMP hydroxymethylase
Important for substrate binding and specificity
Glucosamine/galactosamine-6-phosphate isomerase
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Required for zinc-mediated homotetramerization and catalytic activity
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Calcineurin-like phosphoesterase domain-containing protein
Curli production assembly/transport component CsgG
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Transglycosylase SLT domain-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Type 4 fimbrial biogenesis protein PilX N-terminal
Cell division protein FtsQ/DivIB C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Glycine cleavage T-protein C-terminal barrel
Schiff-base intermediate with substrate; via pyruvic acid
Could be important to modulate the pK values of the two catalytic cysteine residues
Thiol:disulfide interchange protein DsbA
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
PilC beta-propeller domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Outer membrane beta-barrel porin/alpha-amylase
Ribosomal RNA adenine methylase transferase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Saccharopine dehydrogenase-like C-terminal
Flagellar motor switch protein FliN-like C-terminal
DNA mismatch repair proteins mutS family
Molybdopterin cofactor biosynthesis C (MoaC)
Anthranilate synthase component I N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Could play a key role in the communication between the regulatory and the substrate sites
Phosphatidic acid phosphatase type 2/haloperoxidase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Arginine decarboxylase C-terminal helical
NIF system FeS cluster assembly NifU C-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
TonB C-terminal domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal