Glycosyl hydrolase family 98 putative carbohydrate-binding module
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NIF system FeS cluster assembly NifU N-terminal
Important for beta-aspartyl-AMP intermediate formation
Major facilitator superfamily (MFS) profile
Cysteine sulfenic acid (-SOH) intermediate
Pyridoxamine 5'-phosphate oxidase putative
Cell envelope-related transcriptional attenuator
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aminoacyl-transfer RNA synthetases class-II family profile
Quercetin 2,3-dioxygenase C-terminal cupin
Involved in allosteric activation by GTP
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Gram-positive cocci surface proteins LPxTG
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
SUF system FeS cluster assembly SufBD N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Molybdopterin cofactor biosynthesis C (MoaC)
Positions MEP for the nucleophilic attack
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glycosyltransferase family 28 N-terminal
Glycosyl transferase family 3 N-terminal
AB hydrolase-1 domain-containing protein
L,D-transpeptidase catalytic domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Endonuclease/exonuclease/phosphatase domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Removed in mature form; by autocatalysis
Integral membrane protein YccS N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyruvate phosphate dikinase AMP/ATP-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glucosamine/galactosamine-6-phosphate isomerase
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein uL2 C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Peptidase S9 prolyl oligopeptidase catalytic
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Polymerase/histidinol phosphatase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cytochrome bc1 complex cytochrome c subunit
Large ribosomal subunit protein uL15/eL18
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Solute-binding protein family 3/N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Acetylserotonin O-methyltransferase dimerisation
Endoribonuclease L-PSP/chorismate mutase-like
Adaptive response protein AidB N-terminal
Phosphatidylinositol-specific phospholipase C X
Ionotropic glutamate receptor C-terminal
Plays an important role in substrate specificity
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Prokaryotic-type class I peptide chain release factors
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Bacterial type II secretion system protein E
Gp5/Type VI secretion system Vgr protein OB-fold
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Alpha-glycerophosphate oxidase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Alanyl-transfer RNA synthetases family profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Ribose-phosphate pyrophosphokinase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Tryptophan synthase beta chain-like PALP
Gram-positive cocci surface proteins LPxTG domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycosyl transferase family 28 C-terminal
Phosphomannose isomerase type I catalytic
Lactate utilization protein B C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
RNA 2-O ribose methyltransferase substrate binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Transcription regulator AsnC/Lrp ligand binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycoside hydrolase family 42 N-terminal
Penicillin-binding protein transpeptidase
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Small ribosomal subunit protein uS4 N-terminal
Squalene cyclase C-terminal domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyrroline-5-carboxylate reductase catalytic N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
M6 family metalloprotease domain protein
Right handed beta helix domain-containing protein
Fibronectin type-III domain-containing protein
Putative Flp pilus-assembly TadG-like N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Bacterial bifunctional deaminase-reductase C-terminal
4'-phosphopantetheinyl transferase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Butirosin biosynthesis protein H N-terminal
Putative regulatory protein FmdB Zinc ribbon
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Styrene monooxygenase StyA putative substrate binding
Pyruvate dehydrogenase E1 component middle
Beta-hexosaminidase bacterial type N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Microcin J25-processing protein McjB C-terminal
ABC-type glycine betaine transport system substrate-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phosphoribosylformylglycinamidine synthase linker
Phosphotransferase system enzyme I N-terminal
Putative glycogen debranching enzyme N-terminal
Glycosyl hydrolase-like 10 domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Pseudouridine synthase I TruA alpha/beta
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
DNA-directed DNA polymerase family A palm
Alpha-D-phosphohexomutase alpha/beta/alpha
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
PhoD-like phosphatase metallophosphatase
DNA polymerase III delta subunit C-terminal
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Acyltransferase MbtK/IucB-like conserved
Protein O-mannosyl-transferase C-terminal four TM
Heat-inducible transcription repressor HrcA C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycine cleavage T-protein C-terminal barrel
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Anthranilate synthase component I N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Proton acceptor; for glutaminase activity
Peptidase M1 membrane alanine aminopeptidase
Phosphocysteine intermediate; for EIIB activity
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Electron transfer via tryptophanyl radical
Peptide methionine sulphoxide reductase MsrA
Could be important to modulate the pK values of the two catalytic cysteine residues
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Translation elongation factor P/YeiP central
O-(5'-phospho-DNA)-tyrosine intermediate
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Sporulation transcription regulator WhiA N-terminal
Ricin B lectin domain-containing protein
Pyrroline-5-carboxylate reductase dimerisation
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Peptidase M43 pregnancy-associated plasma-A
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
YbaK/aminoacyl-tRNA synthetase-associated
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Signal recognition particle SRP54 helical bundle
Phosphodiester glycosidase domain-containing protein
Reversibly protonated during proton transport
Essential for prephenate dehydratase activity
LPXTG-domain-containing protein cell wall anchor domain protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
CobB/CobQ-like glutamine amidotransferase
Helix-hairpin-helix DNA-binding motif class 1
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
Tat pathway signal sequence domain protein
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Increases nucleophilicity of active site Cys
Myo-inositol-1-phosphate synthase GAPDH-like
Large ribosomal subunit protein bL12 C-terminal
Putative adhesin domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
vWA-MoxR associated protein middle region 2
N6 adenine-specific DNA methyltransferase N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cytochrome b/b6 N-terminal region profile
Release factor glutamine methyltransferase N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Glycoside hydrolase family 42 N-terminal domain-containing protein
Large ribosomal subunit protein bL12 oligomerization
Shikimate dehydrogenase substrate binding N-terminal
LPXTG-motif cell wall anchor domain protein
N-acetylneuraminic acid synthase N-terminal
Cytochrome C biogenesis protein transmembrane
Cytochrome bc1 complex Rieske iron-sulfur subunit
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Erythromycin biosynthesis protein CIII-like central
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
DNA primase/polymerase bifunctional N-terminal
SsuA/THI5-like domain-containing protein
ABC transporter substrate-binding protein PnrA-like
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Methionyl-tRNA synthetase anticodon-binding
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
6-phosphogluconate dehydrogenase NADP-binding
Alpha galactosidase C-terminal beta sandwich
Pyridine nucleotide-disulphide oxidoreductase N-terminal
Prepilin type IV endopeptidase peptidase
Na+/H+ antiporter MnhB subunit-related protein
DNA replication/recombination mediator RecO N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
6-phosphogluconate dehydrogenase C-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Histidine-specific methyltransferase SAM-dependent
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Probable subtilase-type protease inhibitor
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Glycerophosphoryl diester phosphodiesterase family protein
Threonine/serine exporter-like N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Transition state stabilizer; via amide nitrogen
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Peptidoglycan recognition protein family
Heme-copper oxidase subunit III family profile
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Solute-binding protein family 5 domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Peptidase C39-like domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Large ribosomal subunit protein uL30-like ferredoxin-like fold
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal