Major facilitator superfamily (MFS) profile
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Membrane-bound lytic murein transglycosylase A
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
RND efflux pump membrane fusion protein barrel-sandwich
Alpha-glycerophosphate oxidase C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Prepilin type IV endopeptidase peptidase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Serine/threonine specific protein phosphatases
Transcriptional regulator SgrR N-terminal HTH
Phosphatidic acid phosphatase type 2/haloperoxidase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Solute-binding protein family 3/N-terminal
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
YbaK/aminoacyl-tRNA synthetase-associated
Phosphocysteine intermediate; for EIIB activity
Transposase IS116/IS110/IS902 C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Nucleoside-specific channel-forming protein Tsx
Membrane fusion protein biotin-lipoyl like
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Greasy slide, important in sugar transport
Glycoside hydrolase family 31 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Type VI secretion system IcmF C-terminal
Interaction with polymerase core subunit RpoC
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Polypeptide-transport-associated ShlB-type
TonB-dependent receptor-like beta-barrel
Aminoacyl-transfer RNA synthetases class-II family profile
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
L-seryl-tRNA selenium transferase N-terminal
Cob(I)alamin adenosyltransferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Interacts with tRNA; defines subfamily-specific binding signature
Aspartate/homoserine dehydrogenase NAD-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Appears to be important in orienting the phosphate for catalysis
DNA replication/recombination mediator RecO N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Plays an important role in substrate specificity
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Quercetin 2,3-dioxygenase C-terminal cupin
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Resolvase/invertase-type recombinase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Curli production assembly/transport component CsgF
Tryptophan synthase beta chain-like PALP
Type II secretion system protein GspG C-terminal
Essential for prephenate dehydratase activity
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Non-canonical purine NTP phosphatase/PRRC1
RNA 2-O ribose methyltransferase substrate binding
Schiff-base intermediate with substrate; via pyruvic acid
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
O-(3'-phospho-DNA)-tyrosine intermediate
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Large ribosomal subunit protein uL2 C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Glycine cleavage T-protein C-terminal barrel
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Acyltransferase MbtK/IucB-like conserved
Thiol:disulfide interchange protein DsbD
Lysidine-tRNA(Ile) synthetase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
DNA-directed DNA polymerase family A palm
Ribose-phosphate pyrophosphokinase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Cytochrome b561 bacterial/Ni-hydrogenase
Membrane insertase YidC/Oxa/ALB C-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA polymerase III delta subunit C-terminal
Polysaccharide chain length determinant N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
N6 adenine-specific DNA methyltransferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Mechanosensitive ion channel inner membrane
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
D-galactose/methyl-galactoside binding periplasmic protein MglB
ABC-type glycine betaine transport system substrate-binding
Important for beta-aspartyl-AMP intermediate formation
Pyruvate phosphate dikinase AMP/ATP-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Ionotropic glutamate receptor C-terminal
Cation-transporting P-type ATPase N-terminal
Flagella basal body P-ring formation protein FlgA
Required for zinc-mediated homotetramerization and catalytic activity
Outer-membrane lipoprotein carrier protein
Glycyl cysteine dithioester (Cys-Gly) (interchain with G-Cter in ThiS)
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Outer-membrane lipoprotein Wza C-terminal
Polysaccharide biosynthesis protein CapD-like
Penicillin-binding protein activator LpoB
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prokaryotic-type class I peptide chain release factors
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Aconitase A/isopropylmalate dehydratase small subunit swivel
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
4'-phosphopantetheinyl transferase N-terminal
Transposon Tn7 transposition protein TnsD C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Pyrimidine nucleoside phosphorylase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Flagellar hook-length control protein-like C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
ATP synthase F1 complex delta/epsilon subunit N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Outer membrane protein assembly factor BamE
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glucose-6-phosphate isomerase prokaryote
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Glycosyl transferase family 3 N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glutathionylspermidine synthase pre-ATP-grasp-like
tRNA(Met) cytidine acetyltransferase TmcA N-terminal
tRNA(Met) cytidine acetyltransferase TmcA tRNA-binding
DnaJ homologue subfamily C member 28 conserved
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Interaction with tRNA. Important for base-flipping
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Gamma-glutamylcyclotransferase AIG2-like
High-affinity zinc uptake system protein ZnuA
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Schiff-base intermediate with substrate; via topaquinone
Type II secretion system protein GspI C-terminal
Seems to be a necessary countercharge to the potassium cations
Plays an important role in discriminating NADH against NADPH
Mannose-6-phosphate isomerase type II C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Glycoside hydrolase family 42 N-terminal
Outer membrane protein assembly factor BamA
Disulphide bond isomerase DsbC/G N-terminal
ABC-type transport auxiliary lipoprotein component
Helix-hairpin-helix DNA-binding motif class 1
Pyruvate dehydrogenase E1 component middle
Anthranilate synthase component I N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
RNA polymerase sigma factor 70 region 4 type 2
Outer membrane protein assembly factor BamD
Spy/CpxP family protein refolding chaperone
Polymerase/histidinol phosphatase N-terminal
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Translocation and assembly module subunit TamA
Penicillin-insensitive murein endopeptidase
Terminase large subunit-like endonuclease
Small ribosomal subunit protein uS4 N-terminal
Threonine/serine exporter-like N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Integral membrane protein YccS N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Gly-cisPro motif, important for rejection of L-amino acids
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Release factor glutamine methyltransferase N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
DNA-3-methyladenine glycosylase AlkA N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Bacterial bifunctional deaminase-reductase C-terminal
Type I restriction modification DNA specificity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Curli production assembly/transport component CsgG
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Translation elongation factor P/YeiP central
Required for dimer formation and molybdate binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Inosine/uridine-preferring nucleoside hydrolase
Phosphoethanolamine transferase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Lipoprotein YfjS/YafY domain-containing protein
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Molybdopterin cofactor biosynthesis C (MoaC)
Organic solvent tolerance-like N-terminal
Bacterial type II secretion system protein E
NIF system FeS cluster assembly NifU C-terminal
Membrane-bound lytic murein transglycosylase C
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Phage conserved hypothetical protein C-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Outer membrane protein assembly factor BamB
Reversibly protonated during proton transport
Carbamoyl-phosphate synthase small subunit N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Could be important to modulate the pK values of the two catalytic cysteine residues
Lipopolysaccharide export system protein LptA
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Arabinogalactan endo-beta-1,4-galactanase
Ribosomal RNA adenine methylase transferase N-terminal
RNA binding; important for wobble base 34 recognition
SMODS-associating 2TM beta-strand rich effector
Chromosomal replication initiator DnaA C-terminal
Major facilitator superfamily associated
Beta-hexosaminidase bacterial type N-terminal
Large ribosomal subunit protein bL25 L25
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Exopolysaccharide production protein YjbE
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Lytic transglycosylase superhelical linker
Chalcone isomerase domain-containing protein
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Type VI secretion system-associated protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Large ribosomal subunit protein uL6 alpha-beta
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Proline utilization A proline dehydrogenase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Heme-copper oxidase subunit III family profile
Type III secretion system flagellar brake protein YcgR PilZN
HicB-like antitoxin of toxin-antitoxin system
Exonuclease VII large subunit C-terminal
Involved in tetramerization or stability of the tetramer
Bacteriophage lambda Replication protein O N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Electron transfer via tryptophanyl radical
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
DNA polymerase III subunit delta C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Cysteine sulfenic acid (-SOH) intermediate
UDP-glucose/GDP-mannose dehydrogenase C-terminal
6-phosphogluconate dehydrogenase C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Sodium/calcium exchanger membrane region
Curli production assembly/transport component CsgE
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Antitoxin Xre/MbcA/ParS-like toxin-binding
Important for substrate binding and specificity
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Flagellar assembly protein FliH/Type III secretion system HrpE
Large ribosomal subunit protein uL15/eL18
Flagellar motor switch protein FliN N-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Moves into active site upon enzyme activation, plays a role in electron transfer
Thymidylate synthase/dCMP hydroxymethylase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Essential for degradation by Lon protease
Involved in allosteric activation by GTP
Alanyl-transfer RNA synthetases family profile
Penicillin-binding protein activator LpoA
Bacterial transcription activator effector binding
Superoxide dismutase copper/zinc binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Ion-translocating oxidoreductase complex subunit G
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Transcription elongation factor GreA/GreB N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Glucosamine/galactosamine-6-phosphate isomerase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA mismatch repair proteins mutS family
Arginine decarboxylase C-terminal helical
Phosphotransferase system enzyme I N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Menaquinone biosynthesis protein MenD middle
Positions MEP for the nucleophilic attack
Tetrahydrodipicolinate-N-succinyltransferase chain A
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Peptide methionine sulphoxide reductase MsrA
Prepilin peptidase dependent protein C-like C-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase N-terminal
Important for interaction with partner proteins
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom