Positions MEP for the nucleophilic attack
Reversibly protonated during proton transport
Major facilitator superfamily (MFS) profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Solute-binding protein family 3/N-terminal
NIF system FeS cluster assembly NifU N-terminal
Plays an important role in substrate specificity
Outer-membrane lipoprotein carrier protein
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein bL25 L25
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Periplasmic binding protein domain-containing protein
Large ribosomal subunit protein uL15/eL18
Phosphoadenosine phosphosulphate reductase
Ribose-phosphate pyrophosphokinase N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Gamma-glutamylcyclotransferase AIG2-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Chromosomal replication initiator DnaA C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for beta-aspartyl-AMP intermediate formation
Cytochrome b561 bacterial/Ni-hydrogenase
SUF system FeS cluster assembly SufBD N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Membrane fusion protein biotin-lipoyl like
Greasy slide, important in sugar transport
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Alpha-glycerophosphate oxidase C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Tryptophan synthase beta chain-like PALP
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Involved in allosteric activation by GTP
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Important for interaction with partner proteins
Phosphotransferase system enzyme I N-terminal
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Ionotropic glutamate receptor C-terminal
Polymerase/histidinol phosphatase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Involved in tetramerization or stability of the tetramer
NADH:ubiquinone oxidoreductase 30kDa subunit
Plays a key role in the stabilization of the transition state and positioning the aldehyde component
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Could be important to modulate the pK values of the two catalytic cysteine residues
Appears to be important in orienting the phosphate for catalysis
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
NIF system FeS cluster assembly NifU C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
UDP N-acetylglucosamine O-acyltransferase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Glycosyl transferase family 3 N-terminal
Heme-copper oxidase subunit III family profile
Translation elongation factor P/YeiP central
YbaK/aminoacyl-tRNA synthetase-associated
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Outer membrane protein assembly factor BamE
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ribosomal RNA adenine methylase transferase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Prokaryotic-type class I peptide chain release factors
Pyridine nucleotide-disulphide oxidoreductase dimerisation
TonB-dependent receptor-like beta-barrel
Large ribosomal subunit protein uL6 alpha-beta
Sodium/calcium exchanger membrane region
Penicillin-binding protein transpeptidase
RNA binding; important for wobble base 34 recognition
Terminase large subunit gp17-like C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Cob(I)alamin adenosyltransferase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Schiff-base intermediate with substrate; via pyruvic acid
Phosphocysteine intermediate; for EIIB activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Outer membrane protein assembly factor BamB
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Transcription factor NikR nickel binding C-terminal
Large ribosomal subunit protein uL2 C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Cysteine sulfenic acid (-SOH) intermediate
Schiff-base intermediate with acetaldehyde
Small ribosomal subunit protein uS4 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Nucleophile; cysteine thiosulfonate intermediate
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Carbamoyl-phosphate synthase small subunit N-terminal
Outer membrane protein assembly factor BamA
Arginine decarboxylase C-terminal helical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central