Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Major facilitator superfamily associated
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Disulphide bond isomerase DsbC/G N-terminal
Polypeptide-transport-associated ShlB-type
Hypersensitivity response secretion-like HrpJ
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Survival protein SurE-like phosphatase/nucleotidase
YdgH/BhsA/McbA-like domain-containing protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Major facilitator superfamily (MFS) profile
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Involved in allosteric activation by GTP
Outer membrane protein assembly factor BamE
Glycosyltransferase subfamily 4-like N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Chromosomal replication initiator DnaA C-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transposase IS116/IS110/IS902 C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
TonB-dependent receptor-like beta-barrel
Fimbrial-type adhesion domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Probable transposase IS891/IS1136/IS1341
Glucosamine/galactosamine-6-phosphate isomerase
L-seryl-tRNA selenium transferase N-terminal
Prokaryotic-type class I peptide chain release factors
Phosphocysteine intermediate; for EIIB activity
O-(5'-phospho-DNA)-tyrosine intermediate
Heme-copper oxidase subunit III family profile
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Essential for prephenate dehydratase activity
Aromatic amino acid beta-eliminating lyase/threonine aldolase
RNA polymerase sigma factor 70 region 4 type 2
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Inosine/uridine-preferring nucleoside hydrolase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Membrane fusion protein biotin-lipoyl like
Alanyl-transfer RNA synthetases family profile
6-phosphogluconate dehydrogenase C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Sugar fermentation stimulation protein C-terminal
Carbapenam-3-carboxylate synthase N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Type VI secretion system IcmF C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Membrane insertase YidC/Oxa/ALB C-terminal
Outer membrane protein assembly factor BamB
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cysteine sulfenic acid (-SOH) intermediate
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Resolvase/invertase-type recombinase catalytic
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Solute-binding protein family 3/N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Pullulanase carbohydrate-binding module 41
Essential for degradation by Lon protease
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Contractile injection system tube protein N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Gp5/Type VI secretion system Vgr protein OB-fold
Divergent polysaccharide deacetylase family protein
RND efflux pump membrane fusion protein barrel-sandwich
Helix-hairpin-helix DNA-binding motif class 1
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Large ribosomal subunit protein uL15/eL18
Iron ABC transporter substrate-binding protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Type I restriction modification DNA specificity
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Schiff-base intermediate with acetaldehyde
Polymerase/histidinol phosphatase N-terminal
ABC-type transport auxiliary lipoprotein component
Tryptophan synthase beta chain-like PALP
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Important for substrate binding and specificity
Outer-membrane lipoprotein Wza C-terminal
HicB-like antitoxin of toxin-antitoxin system
YbaK/aminoacyl-tRNA synthetase-associated
Important for interaction with partner proteins
NIF system FeS cluster assembly NifU C-terminal
Putative type VI secretion system Rhs element associated Vgr
Phosphatidylglycerol lysyltransferase C-terminal
Translation elongation factor P/YeiP central
Bacterial type II secretion system protein E
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
DNA mismatch repair proteins mutS family
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyruvate phosphate dikinase AMP/ATP-binding
Phosphoadenosine phosphosulphate reductase
Outer membrane protein assembly factor BamA
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Molybdopterin cofactor biosynthesis C (MoaC)
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glycine cleavage T-protein C-terminal barrel
DNA replication/recombination mediator RecO N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Bacterial bifunctional deaminase-reductase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA 2-O ribose methyltransferase substrate binding
Type III secretion system effector delivery regulator TyeA
Ribose-phosphate pyrophosphokinase N-terminal
Interaction with polymerase core subunit RpoC
TRAP C4-dicarboxylate transport system permease DctM subunit
Chitobiase/beta-hexosaminidases N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Prepilin type IV endopeptidase peptidase
Flagellar hook-length control protein-like C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Transferrin-binding protein B C-lobe/N-lobe beta barrel
Transferrin-binding protein B C-lobe/N-lobe beta barrel domain-containing protein
Gamma-glutamylcyclotransferase AIG2-like
Calcium-dependent cell adhesion molecule 1 membrane-binding
Calcium-dependent cell adhesion molecule N-terminal
Release factor glutamine methyltransferase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Transcriptional regulator AbiEi antitoxin N-terminal
Penicillin-binding protein transpeptidase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Alpha-glycerophosphate oxidase C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Involved in tetramerization or stability of the tetramer
Carbamoyl-phosphate synthase small subunit N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Outer membrane protein assembly factor BamD
Tetrahydrodipicolinate-N-succinyltransferase chain A
Ionotropic glutamate receptor C-terminal
Proton acceptor; for glutaminase activity
Large ribosomal subunit protein bL25 L25
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Anthranilate synthase component I N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Polysaccharide chain length determinant N-terminal
Lytic transglycosylase superhelical linker
Plays an important role in substrate specificity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Cytochrome b561 bacterial/Ni-hydrogenase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Tle cognate immunity protein 4 C-terminal
Tle cognate immunity protein 4 N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Pyruvate dehydrogenase E1 component middle
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Chromosomal replication initiator protein DnaA
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
tRNA(Met) cytidine acetyltransferase TmcA N-terminal
tRNA(Met) cytidine acetyltransferase TmcA tRNA-binding
Polysaccharide biosynthesis protein CapD-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Required for zinc-mediated homotetramerization and catalytic activity
Putative conjugal transfer nickase/helicase TraI C-terminal
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Haem-binding uptake Tiki superfamily ChaN
Bacterial OB-fold domain-containing protein
Reversibly protonated during proton transport
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Cytotoxic necrotizing factor Rho-activating
Iron-sulfur cluster assembly scaffold protein SufA
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Small ribosomal subunit protein uS4 N-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal domain-containing protein
Thiol:disulfide interchange protein DsbD
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Nitrite/Sulfite reductase ferredoxin-like
N6 adenine-specific DNA methyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Integral membrane protein YccS N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
DNA polymerase III subunit delta C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Terminase large subunit gp17-like C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Prepilin peptidase dependent protein C-like C-terminal
Proline utilization A proline dehydrogenase N-terminal
Secretin/TonB short N-terminal domain-containing protein
Menaquinone biosynthesis protein MenD middle
ATP synthase F1 complex delta/epsilon subunit N-terminal
Required for dimer formation and molybdate binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Lysidine-tRNA(Ile) synthetase C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Gly-cisPro motif, important for rejection of L-amino acids
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
ABC-type glycine betaine transport system substrate-binding
DNA polymerase III delta subunit C-terminal
Thymidylate synthase/dCMP hydroxymethylase
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein uL6 alpha-beta
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Arginine decarboxylase C-terminal helical
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Yop protein translocation protein D periplasmic
Phosphotransferase system enzyme I N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Large ribosomal subunit protein uL2 C-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Tc toxin complex TcA C-terminal TcB-binding
Transcriptional regulator SgrR N-terminal HTH
Phosphoethanolamine transferase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Phage terminase large subunit N-terminal
Outer-membrane lipoprotein carrier protein
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Non-canonical purine NTP phosphatase/PRRC1
Mechanosensitive ion channel inner membrane
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Could be important to modulate the pK values of the two catalytic cysteine residues
DNA-directed DNA polymerase family A palm
C4-dicarboxylate ABC transporter substrate-binding protein
Translocation and assembly module subunit TamA
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Nucleophile; cysteine thiosulfonate intermediate
Positions MEP for the nucleophilic attack
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Sodium/calcium exchanger membrane region
BAAT/Acyl-CoA thioester hydrolase C-terminal
BAAT/Acyl-CoA thioester hydrolase C-terminal domain-containing protein