4'-phosphopantetheinyl transferase N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Putative ABC transporter ATP-binding protein SAV_5847
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
1-deoxy-D-xylulose-5-phosphate synthase 1
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Major facilitator superfamily (MFS) profile
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Polymerase/histidinol phosphatase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Methionine import ATP-binding protein MetN
Gram-positive cocci surface proteins LPxTG
Small ribosomal subunit biogenesis GTPase RsgA
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Aminoacyl-transfer RNA synthetases class-II family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Arabinogalactan endo-beta-1,4-galactanase
Microcin J25-processing protein McjB C-terminal
Solute-binding protein family 3/N-terminal
Carbamoyl-phosphate synthase large chain
Involved in ionization of N3 of dUMP, leading to its activation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Cell envelope-related transcriptional attenuator
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Probable 5-dehydro-4-deoxyglucarate dehydratase 1
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Ribosomal RNA small subunit methyltransferase A
Adaptive response protein AidB N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Phosphomannose isomerase type I catalytic
Glycoside hydrolase family 42 N-terminal
Penicillin-binding protein transpeptidase
Imidazole glycerol phosphate synthase subunit HisH
Aliphatic sulfonates import ATP-binding protein SsuB 1
Glycosyltransferase subfamily 4-like N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
PhoD-like phosphatase metallophosphatase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Transition state stabilizer; via amide nitrogen
Putative oxidoreductase/dehydrogenase Rossmann-like
Anthranilate synthase component I N-terminal
3-methyl-2-oxobutanoate hydroxymethyltransferase
Conserved hypothetical protein CHP02679 N terminus
1-deoxy-11-beta-hydroxypentalenate dehydrogenase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pyruvate dehydrogenase E1 component middle
Glucose-methanol-choline oxidoreductase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Prokaryotic-type class I peptide chain release factors
Glycosyl hydrolase family 95 N-terminal domain-containing protein
Cytochrome C biogenesis protein transmembrane
Probable subtilase-type protease inhibitor
Potassium-transporting ATPase potassium-binding subunit
ABC-type glycine betaine transport system substrate-binding
Glutathionylspermidine synthase pre-ATP-grasp-like
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Phosphoadenosine phosphosulphate reductase
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Heat-inducible transcription repressor HrcA
Glycoside hydrolase family 31 N-terminal
Glycerophosphoryl diester phosphodiesterase membrane
Chromosomal replication initiator protein DnaA
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prepilin type IV endopeptidase peptidase
RNA polymerase sigma factor 70 region 4 type 2
Phosphotransferase system enzyme I N-terminal
NIF system FeS cluster assembly NifU N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Saccharopine dehydrogenase-like C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Tryptophan synthase beta chain-like PALP
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ribose import ATP-binding protein RbsA 1
Reversibly protonated during proton transport
Beta-ketoacyl-[acyl-carrier-protein] synthase III 1
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Plays an important role in substrate specificity
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
DNA primase/polymerase bifunctional N-terminal
Peptidase M1 membrane alanine aminopeptidase
tRNA N6-adenosine threonylcarbamoyltransferase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Bacterial type II secretion system protein E
Putative serine protease inhibitor SAV_2156
Uncharacterized N-acetyltransferase SAV_5428
Cell wall-active antibiotics response LiaF-like C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Electron transfer via tryptophanyl radical
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
ABC transporter substrate-binding protein PnrA-like
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Carbamoyl-phosphate synthase small chain
RNA 2-O ribose methyltransferase substrate binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Peptidoglycan recognition protein family
ATP-dependent dethiobiotin synthetase BioD
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Removed in mature form; by autocatalysis
Crossover junction endodeoxyribonuclease RuvC
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Putative pterin-4-alpha-carbinolamine dehydratase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Sec-independent protein translocase protein TatA
Glutamate-1-semialdehyde 2,1-aminomutase
Uncharacterized N-acetyltransferase SAV_4024
Cytochrome b561 bacterial/Ni-hydrogenase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Vitamin B12-dependent ribonucleotide reductase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Fe(3+) ions import ATP-binding protein FbpC
Pyrimidine nucleoside phosphorylase C-terminal
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Cytochrome bc1 complex cytochrome c subunit
Could be important to modulate the pK values of the two catalytic cysteine residues
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA-directed RNA polymerase subunit beta
NADH:flavin oxidoreductase/NADH oxidase N-terminal
3-isopropylmalate dehydratase large subunit
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Phosphate import ATP-binding protein PstB
Resolvase/invertase-type recombinase catalytic
Interaction with polymerase core subunit RpoC
NADH:ubiquinone oxidoreductase-like 20kDa subunit
DnaJ homologue subfamily C member 28 conserved
ATP-dependent Clp protease ATP-binding subunit ClpX
Glutamyl-tRNA(Gln) amidotransferase subunit A
Pyrroline-5-carboxylate reductase dimerisation
Lactate utilization protein B C-terminal
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Essential for prephenate dehydratase activity
CobB/CobQ-like glutamine amidotransferase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
Polyketide-8 synthase acyl carrier protein 2
DNA-directed RNA polymerase subunit alpha
Phosphatidic acid phosphatase type 2/haloperoxidase
Transposase IS116/IS110/IS902 C-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Holliday junction branch migration complex subunit RuvB
Alpha-L-arabinofuranosidase B arabinose-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Styrene monooxygenase StyA putative substrate binding
Polyribonucleotide nucleotidyltransferase
DNA-directed RNA polymerase subunit beta'
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glyceraldehyde-3-phosphate dehydrogenase 1
Potassium-transporting ATPase KdpC subunit
Proton acceptor; for glutaminase activity
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Probable transposase IS891/IS1136/IS1341
Peptidase S9 prolyl oligopeptidase catalytic
Nucleophile; cysteine thiosulfonate intermediate
Probable transcriptional regulatory protein SAV_6832
N-acetylmuramic acid 6-phosphate etherase
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) 1
N-acetylneuraminic acid synthase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Transcription regulator AsnC/Lrp ligand binding
Diaminobutyrate--2-oxoglutarate transaminase
ATP-dependent Clp protease adapter protein ClpS
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Sodium/calcium exchanger membrane region
Putative glycogen debranching enzyme N-terminal
Cyclic pyranopterin monophosphate synthase
Phosphocysteine intermediate; for EIIB activity
Quercetin 2,3-dioxygenase C-terminal cupin
Ribose import ATP-binding protein RbsA 2
ATP-dependent Clp protease proteolytic subunit 5
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Ionotropic glutamate receptor C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III 2
Aliphatic sulfonates import ATP-binding protein SsuB 2
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Probable cytochrome c oxidase polypeptide 4
Involved in Mg(2+) ion dislocation from EF-Tu
Cytochrome b/b6 N-terminal region profile
ATP-dependent Clp protease proteolytic subunit 4
Integral membrane protein YccS N-terminal
Alpha-glycerophosphate oxidase C-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
Docks into pockets in the proteasome alpha-ring
Pyridoxal 5'-phosphate synthase subunit PdxT
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
3-isopropylmalate dehydratase small subunit
Gly-cisPro motif, important for rejection of L-amino acids
DNA-directed DNA polymerase family A palm
Pyridoxine/pyridoxamine 5'-phosphate oxidase
Phosphoribosylformylglycinamidine synthase subunit PurQ
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Electron transfer flavoprotein alpha/beta-subunit N-terminal
DNA-directed RNA polymerase subunit omega
Beta-hexosaminidase bacterial type N-terminal
Glyceraldehyde-3-phosphate dehydrogenase 2
Shikimate dehydrogenase substrate binding N-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Formamidopyrimidine-DNA glycosylase catalytic
Putative membrane protein insertion efficiency factor
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Histidine-specific methyltransferase SAM-dependent
MmyB-like transcription regulator ligand binding
Nicotinate phosphoribosyltransferase N-terminal
ATP-dependent Clp protease proteolytic subunit 2
Imidazole glycerol phosphate synthase subunit HisF
Glycine cleavage T-protein C-terminal barrel
Ribosomal protein uS12 methylthiotransferase RimO
N-acetyl-gamma-glutamyl-phosphate reductase
L-2,4-diaminobutyric acid acetyltransferase
Putative cytochrome c oxidase subunit 1-beta
SUF system FeS cluster assembly SufBD N-terminal
4-hydroxy-tetrahydrodipicolinate reductase
Na+/H+ antiporter MnhB subunit-related protein
YbaK/aminoacyl-tRNA synthetase-associated
NADH:ubiquinone oxidoreductase 30kDa subunit
FMN-dependent NADH:quinone oxidoreductase
Glucosamine/galactosamine-6-phosphate isomerase
Protein O-mannosyl-transferase C-terminal four TM
Pyridoxal 5'-phosphate synthase subunit PdxS
Schiff-base intermediate with D-ribose 5-phosphate
Glycosyltransferase family 28 N-terminal
Schiff-base intermediate with substrate; via topaquinone
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
15-fold reduction in catalytic efficiency with AFL as substrate, but nearly no effect on catalytic efficiency with adenosine as substrate.
30-fold reduction in catalytic efficiency with AFL as substrate, but nearly no effect on catalytic efficiency with adenosine as substrate.
Putative Flp pilus-assembly TadG-like N-terminal
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Probable dual-specificity RNA methyltransferase RlmN
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
ATP-dependent Clp protease proteolytic subunit 1
Phosphoribosylformylglycinamidine synthase subunit PurL
Transcription antitermination protein NusB
3-phosphoshikimate 1-carboxyvinyltransferase
Endoribonuclease L-PSP/chorismate mutase-like
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) 2
Acyltransferase MbtK/IucB-like conserved
Ribosomal RNA small subunit methyltransferase G
Urease accessory protein UreH-like transmembrane
Sec-independent protein translocase protein TatB
Damage-control phosphatase ARMT1-like metal-binding
Redox-sensing transcriptional repressor Rex
1-deoxy-D-xylulose-5-phosphate synthase 2
1-deoxypentalenic acid 11-beta-hydroxylase
Abolishes 1-deoxypentalenic acid 11-beta-hydroxylase activity.
Strong reduction of 1-deoxypentalenic acid 11-beta-hydroxylase activity.
Putative 3-methyladenine DNA glycosylase
Probable cytochrome c oxidase subunit 1-alpha
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Involved in allosteric activation by GTP
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
CASTOR/POLLUX/SYM8 ion channel conserved
Peptide methionine sulfoxide reductase MsrA
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Holliday junction branch migration complex subunit RuvA
Membrane insertase YidC/Oxa/ALB C-terminal
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
K(+)-insensitive pyrophosphate-energized proton pump
Deoxyguanosinetriphosphate triphosphohydrolase-like protein