Uncharacterized HTH-type transcriptional regulator aq_603
tRNA N6-adenosine threonylcarbamoyltransferase
Histidine biosynthesis bifunctional protein HisIE
Probable glycine dehydrogenase (decarboxylating) subunit 2
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Schiff-base intermediate with acetaldehyde
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Uncharacterized metallophosphoesterase aq_1054
RNA binding; important for wobble base 34 recognition
RNA 2-O ribose methyltransferase substrate binding
4-hydroxy-tetrahydrodipicolinate synthase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
O-(3'-phospho-DNA)-tyrosine intermediate
Sec-independent protein translocase protein TatA 1
ATP phosphoribosyltransferase regulatory subunit
Phenylalanine--tRNA ligase alpha subunit
RND efflux pump membrane fusion protein barrel-sandwich
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphoribosylaminoimidazole-succinocarboxamide synthase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase
Uncharacterized protein aq_1391/aq_1640/aq_aa40
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
NADPH-dependent 7-cyano-7-deazaguanine reductase
Uncharacterized RNA pseudouridine synthase aq_1464
Flagellar basal-body/hook protein C-terminal
Major facilitator superfamily (MFS) profile
Bifunctional IPC transferase and DIPP synthase
Flagellar basal body rod protein N-terminal
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Imidazole glycerol phosphate synthase subunit HisH
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Flagellar hook-basal body complex protein FliE
Ribonucleoside-diphosphate reductase subunit beta, 1st part
Ribonucleoside-diphosphate reductase subunit beta, 2nd part
Elongation factor P--(R)-beta-lysine ligase homolog
Curli production assembly/transport component CsgG
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Gly-cisPro motif, important for rejection of L-amino acids
DNA-directed RNA polymerase subunit omega
Important for guanine/8-oxoguanine distinction
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
Schiff-base intermediate with substrate; via pyruvic acid
Succinate--CoA ligase [ADP-forming] subunit alpha
Polymerase/histidinol phosphatase N-terminal
Glycyl cysteine dithioester (Cys-Gly) (interchain with G-Cter in ThiS)
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Reduces the CMP incorporation at position 74 of the tRNA, but does not affect the CMP incorporation at position 75.
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cation-transporting P-type ATPase N-terminal
Prepilin type IV endopeptidase peptidase
Glycosyltransferase subfamily 4-like N-terminal
Putative arsenical pump-driving ATPase 2
Mannose-6-phosphate isomerase type II C-terminal
Glutamate-1-semialdehyde 2,1-aminomutase
Carbamoyl-phosphate synthase large chain, N-terminal section
Interaction with polymerase core subunit RpoC
Probable nicotinate-nucleotide adenylyltransferase
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Important in orienting the L-aspartate substrate
UDP-N-acetylenolpyruvoylglucosamine reductase
ATP-dependent protease ATPase subunit HslU
Bacterial type II secretion system protein E
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
Chromosomal replication initiator protein DnaA
Type II secretion system protein GspG C-terminal
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Bifunctional purine biosynthesis protein PurH
ATP-dependent Clp protease ATP-binding subunit ClpX
Pyruvate/ketoisovalerate oxidoreductase catalytic
Penicillin-binding protein transpeptidase
Threonylcarbamoyladenosine tRNA methylthiotransferase MtaB
Acyl-ester intermediate; for transpeptidase activity
Helical; Signal-anchor for type II membrane protein
Proton donor; for transglycosylase activity
Loss of catalytic activity. Reduces binding to inhibitor.
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Hypoxanthine-guanine phosphoribosyltransferase
Phosphatidic acid phosphatase type 2/haloperoxidase
Cytochrome C biogenesis protein transmembrane
Putative L-lysine 2,3-aminomutase aq_454
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Cyclic pyranopterin monophosphate synthase
Molybdenum cofactor biosynthesis protein C
3-oxoacyl-[acyl-carrier-protein] reductase FabG
Abnormal spindle-like microcephaly-associated protein ASH
Involved in allosteric activation by GTP
Uncharacterized MscS family protein aq_812
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Plays an important role in substrate specificity
Damage-control phosphatase ARMT1-like metal-binding
Transcription termination/antitermination protein NusG
GDP-mannose:di-myo-inositol-1,3'-phosphate beta-1,2-mannosyltransferase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Glycoside-hydrolase family GH114 TIM-barrel
Methylthioribulose-1-phosphate dehydratase
Probable transcriptional regulatory protein aq_1575
Sugar fermentation stimulation protein homolog
1-deoxy-D-xylulose 5-phosphate reductoisomerase
NADH-quinone oxidoreductase subunit C/D 2
Alpha-D-phosphohexomutase alpha/beta/alpha
ADP-dependent (S)-NAD(P)H-hydrate dehydratase
Bifunctional NAD(P)H-hydrate repair enzyme Nnr
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Putative arsenical pump-driving ATPase 1
Ribonucleoside-diphosphate reductase subunit alpha
2-dehydro-3-deoxyphosphooctonate aldolase
Flagellar motor switch protein FliN-like C-terminal
Disulphide bond isomerase DsbC/G N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Helix-hairpin-helix DNA-binding motif class 1
Transcription antitermination protein NusB
Imidazole glycerol phosphate synthase subunit HisF
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Probable inorganic carbon transporter subunit DabA
Cytochrome oxidase subunit II copper A binding
Putative pterin-4-alpha-carbinolamine dehydratase
Ribosomal protein uS12 methylthiotransferase RimO
Uncharacterized phosphosugar isomerase aq_1546
Sec-independent protein translocase protein TatC
Ferredoxin oxidoreductase 1 subunit ForD
Could be important to modulate the pK values of the two catalytic cysteine residues
Lipoprotein-releasing system ATP-binding protein LolD
RlpA-like protein double-psi beta-barrel
4-hydroxy-tetrahydrodipicolinate reductase
N5-carboxyaminoimidazole ribonucleotide mutase
ATP-dependent Clp protease proteolytic subunit
Flavocytochrome c sulphide dehydrogenase flavin-binding
TonB-dependent receptor-like beta-barrel
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ferredoxin oxidoreductase 2 subunit ForD
Putative outer membrane protein assembly factor BamD
Uncharacterized globin-like protein aq_211
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Sodium/calcium exchanger membrane region
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase
ATP-dependent dethiobiotin synthetase BioD
Proton acceptor; for glutaminase activity
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
Ribosomal RNA small subunit methyltransferase E
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Tryptophan synthase beta chain-like PALP
3-phosphoshikimate 1-carboxyvinyltransferase
3-methyl-2-oxobutanoate hydroxymethyltransferase
Putative membrane protein insertion efficiency factor
Probable dual-specificity RNA methyltransferase RlmN
Putative dihydroorotate dehydrogenase A (fumarate)
Polyribonucleotide nucleotidyltransferase
Signal recognition particle receptor FtsY
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
S-adenosylmethionine:tRNA ribosyltransferase-isomerase
Putative L-lysine 2,3-aminomutase aq_1632
Glutamyl-tRNA(Gln) amidotransferase subunit C
DNA-directed RNA polymerase subunit alpha
Probable endolytic peptidoglycan transglycosylase RlpA
Phosphate-specific transport system accessory protein PhoU homolog
Probable 6-oxopurine nucleoside phosphorylase
ATP-grasp fold succinyl-CoA synthetase-type
3-deoxy-D-manno-octulosonic acid transferase
Nearly complete loss of catalytic activity.
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
N5-carboxyaminoimidazole ribonucleotide synthase
NADH-quinone oxidoreductase subunit C/D 1
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Putative 8-amino-7-oxononanoate synthase
Probable septum site-determining protein MinC
Sec translocon accessory complex subunit YajC
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Carbamoyl-phosphate synthase small chain
Decreased processing of pre-tRNA-CCA-N(8), removes perhaps 4/8 nucleotides, binds tRNA slightly less well than wild-type.
No processing of pre-tRNA-CCA-N(8), binds tRNA as well as wild-type.
Poor processing of pre-tRNA-CCA-N(8), removes a few nucleotides, binds tRNA better than wild-type.
DNA-directed RNA polymerase subunit beta
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
5,10-methylenetetrahydrofolate reductase
Deoxyuridine 5'-triphosphate nucleotidohydrolase
tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase
Phosphoribosylformylglycinamidine synthase subunit PurQ
Probable transposase IS891/IS1136/IS1341
4-hydroxythreonine-4-phosphate dehydrogenase
Gfo/Idh/MocA-like oxidoreductase N-terminal
Probable glycine dehydrogenase (decarboxylating) subunit 1
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Heme-copper oxidase subunit III family profile
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Bifunctional chorismate mutase/prephenate dehydratase
Essential for prephenate dehydratase activity
Cysteine sulfenic acid (-SOH) intermediate
Ribosomal RNA small subunit methyltransferase H
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Succinate--CoA ligase [ADP-forming] subunit beta
Important for interaction with partner proteins
tRNA (guanosine(18)-2'-O)-methyltransferase
Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog
May play a role in metal incorporation in vivo
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Membrane fusion protein biotin-lipoyl like
Phosphate import ATP-binding protein PstB
Glycoside hydrolase family 57 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
O-(5'-phospho-DNA)-tyrosine intermediate
Phosphoribosylformylglycinamidine synthase subunit PurL
Probable protein adenylyltransferase aq_aa38
Important for prephenate aminotransferase activity
Probable aspartate/prephenate aminotransferase
Ribosomal RNA small subunit methyltransferase A
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glutamyl-tRNA(Gln) amidotransferase subunit A
Sec-independent protein translocase protein TatA 2
Iron-sulfur cluster assembly scaffold protein IscU
Stabilizes 2Fe-2S cluster binding, prolongs its half-life in air.
Haem-binding uptake Tiki superfamily ChaN
N-acetyl-gamma-glutamyl-phosphate reductase
No change in DNA-guided RNA cleavage or ssRNA binding, decreased recognition of the 3'-overhang of a dsRNA duplex.
Oxygen-independent coproporphyrinogen III oxidase
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Uncharacterized RNA pseudouridine synthase aq_554
5-methylthioadenosine/S-adenosylhomocysteine deaminase
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Ribosomal RNA small subunit methyltransferase G
Dihydroorotate dehydrogenase electron transfer subunit iron-sulphur cluster binding
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
6-carboxy-5,6,7,8-tetrahydropterin synthase
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Beta-ketoacyl-[acyl-carrier-protein] synthase III
Fibronectin type-III domain-containing protein
N-(5'-phosphoribosyl)anthranilate isomerase
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
Uncharacterized RNA methyltransferase aq_257
6-phosphogluconate dehydrogenase C-terminal
Carbamoyl-phosphate synthase large chain, C-terminal section
Uncharacterized RNA pseudouridine synthase aq_1758
DNA-directed RNA polymerase subunit beta'
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Bifunctional phosphoglucose/phosphomannose isomerase
Myo-inositol-1-phosphate synthase GAPDH-like
Flagellar assembly protein FliH/Type III secretion system HrpE
Probable DNA double-strand break repair Rad50 ATPase
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
3-deoxy-manno-octulosonate cytidylyltransferase
3-isopropylmalate dehydratase large subunit
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glyceraldehyde-3-phosphate dehydrogenase
10-fold decrease in activity. 3.6-fold decrease in zinc content.
20-fold decrease in activity. 2-fold decrease in zinc content.
720-fold decrease in activity. 16.6-fold decrease in zinc content.
Almost loss of activity. 1.5-fold decrease in zinc content.
Almost loss of activity. 10-fold decrease in zinc content.
Loss of activity. 4.3-fold decrease in zinc content.
UDP-3-O-acyl-N-acetylglucosamine deacetylase
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE