ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cytochrome oxidase subunit II copper A binding
Major facilitator superfamily (MFS) profile
Schiff-base intermediate with acetaldehyde
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Alpha-glycerophosphate oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Resolvase/invertase-type recombinase catalytic
Bacterial transcription activator effector binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Aminoacyl-transfer RNA synthetases class-II family profile
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
6-phosphogluconate dehydrogenase C-terminal
ABC-type glycine betaine transport system substrate-binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alanyl-transfer RNA synthetases family profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glucose-methanol-choline oxidoreductase C-terminal
Glycosyltransferase family 28 N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glycosyltransferase subfamily 4-like N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
SsuA/THI5-like domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Tryptophan synthase beta chain-like PALP
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glucose-methanol-choline oxidoreductase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Peptidase M1 membrane alanine aminopeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
2,4-diaminopentanoate dehydrogenase C-terminal
Polysaccharide biosynthesis protein C-terminal
Phosphoribosylformylglycinamidine synthase linker
Glutathionylspermidine synthase pre-ATP-grasp-like
Resuscitation-promoting factor core lysozyme-like
Could be important to modulate the pK values of the two catalytic cysteine residues
Methionyl-tRNA synthetase anticodon-binding
Fatty acid synthase subunit PfaD N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Cell envelope-related transcriptional attenuator
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
SUF system FeS cluster assembly SufBD N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Proteinase inhibitor I42 chagasin domain-containing protein
Iron ABC transporter substrate-binding protein
Important for beta-aspartyl-AMP intermediate formation
Gfo/Idh/MocA-like oxidoreductase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Penicillin-binding protein transpeptidase
Thymidylate synthase/dCMP hydroxymethylase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
DNA replication/recombination mediator RecO N-terminal
Prealbumin-like fold domain-containing protein
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Removed in mature form; by autocatalysis
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Translation elongation factor P/YeiP central
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Transposase IS116/IS110/IS902 C-terminal
Peptide methionine sulphoxide reductase MsrA
Glutamate synthase alpha subunit C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Reversibly protonated during proton transport
Membrane insertase YidC/Oxa/ALB C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Gly-cisPro motif, important for rejection of L-amino acids
Important for substrate specificity; cannot use PPi as phosphoryl donor
Solute-binding protein family 5 domain-containing protein
Glycosyl transferase family 3 N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Butirosin biosynthesis protein H N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
RNA 2-O ribose methyltransferase substrate binding
Pyruvate phosphate dikinase AMP/ATP-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Prokaryotic-type class I peptide chain release factors
Heme-copper oxidase subunit III family profile
Exonuclease VII large subunit C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Heat-inducible transcription repressor HrcA C-terminal
Solute-binding protein family 3/N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)
Threonine/serine exporter-like N-terminal
Plays an important role in substrate specificity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Inner membrane protein YgaP-like transmembrane
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glycosyl transferase family 28 C-terminal
Small ribosomal subunit protein uS4 N-terminal
Transcription regulator AsnC/Lrp ligand binding
Carbamoyl-phosphate synthase small subunit N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Putative glycogen debranching enzyme N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
O-(3'-phospho-DNA)-tyrosine intermediate
Schiff-base intermediate with substrate; via topaquinone
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
DNA-directed DNA polymerase family A palm
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Phosphocysteine intermediate; for EIIB activity
Beta-lactamase-related domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Chromosomal replication initiator DnaA C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prepilin type IV endopeptidase peptidase
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Interaction with polymerase core subunit RpoC
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Release factor glutamine methyltransferase N-terminal
Phosphotransferase system enzyme I N-terminal
Putative regulatory protein FmdB Zinc ribbon
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Could play a key role in the communication between the regulatory and the substrate sites
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cytochrome C biogenesis protein transmembrane
4'-phosphopantetheinyl transferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
ABC transporter substrate-binding protein PnrA-like
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Large ribosomal subunit protein uL15/eL18
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cysteine sulfenic acid (-SOH) intermediate
Bacterial type II secretion system protein E
Glycine cleavage T-protein C-terminal barrel
Leucine-binding protein domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Gfo/Idh/MocA-like oxidoreductase C-terminal
Inosine/uridine-preferring nucleoside hydrolase
CobB/CobQ-like glutamine amidotransferase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Haemophore haem-binding domain-containing protein
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
ATP synthase F1 complex delta/epsilon subunit N-terminal
2-isopropylmalate synthase LeuA allosteric (dimerisation)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Cytochrome b/b6 N-terminal region profile
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Mandelate racemase/muconate lactonizing enzyme C-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
3-beta hydroxysteroid dehydrogenase/isomerase
Myo-inositol-1-phosphate synthase GAPDH-like
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Rv2525c-like glycoside hydrolase-like domain-containing protein
Ribulose bisphosphate carboxylase small subunit
Large ribosomal subunit protein uL6 alpha-beta
Superoxide dismutase copper/zinc binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphomannose isomerase type I catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Resuscitation-promoting factor Rpf1 C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Shikimate dehydrogenase substrate binding N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Sporulation transcription regulator WhiA N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Essential for prephenate dehydratase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Excalibur calcium-binding domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Nitrate ABC transporter substrate-binding protein
Pyruvate dehydrogenase E1 component middle
Glucosamine/galactosamine-6-phosphate isomerase
SGNH hydrolase-type esterase domain-containing protein
Pyrroline-5-carboxylate reductase dimerisation
Anthranilate synthase component I N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Putative Flp pilus-assembly TadG-like N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Putative oxidoreductase/dehydrogenase Rossmann-like
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
MmyB-like transcription regulator ligand binding
Adaptive response protein AidB N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal