Gp5/Type VI secretion system Vgr protein OB-fold
Sodium/calcium exchanger membrane region
Major facilitator superfamily (MFS) profile
Histidine-specific methyltransferase SAM-dependent
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Interacts with tRNA; defines subfamily-specific binding signature
Aminoacyl-transfer RNA synthetases class-II family profile
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
TonB-dependent receptor-like beta-barrel
SUF system FeS cluster assembly SufBD N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Glycine zipper 2TM domain-containing protein
Interaction with polymerase core subunit RpoC
Membrane fusion protein biotin-lipoyl like
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Antitoxin Xre/MbcA/ParS-like toxin-binding
Peptide methionine sulphoxide reductase MsrA
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
RNA polymerase sigma factor 70 region 4 type 2
Glycosyltransferase subfamily 4-like N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
Bacteriophage N4 adsorption protein A C-terminal
Bacteriophage N4 adsorption protein A C-terminal domain-containing protein
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Ysc84 actin-binding domain-containing protein
Superoxide dismutase copper/zinc binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucan biosynthesis periplasmic MdoG C-terminal
Heme-copper oxidase subunit III family profile
Polysaccharide chain length determinant N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Transposase IS116/IS110/IS902 C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL6 alpha-beta
Bacterial type II secretion system protein E
DNA topoisomerase I catalytic core eukaryotic-type
YpeB-like protein with protease inhibitory function
Positions MEP for the nucleophilic attack
C-type lysozyme inhibitor domain-containing protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Nuclear transport factor 2 family protein
O-(5'-phospho-DNA)-tyrosine intermediate
Flagellar motor switch protein FliN-like C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
L,D-transpeptidase catalytic domain-containing protein
Restriction endonuclease type I HsdR N-terminal
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Polymerase/histidinol phosphatase N-terminal
S-adenosylmethionine-dependent methyltransferase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Lysidine-tRNA(Ile) synthetase C-terminal
Important for beta-aspartyl-AMP intermediate formation
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Outer membrane protein beta-barrel domain-containing protein
3-beta hydroxysteroid dehydrogenase/isomerase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
UDP N-acetylglucosamine O-acyltransferase C-terminal
Signal transduction histidine kinase internal region
Biopterin-dependent aromatic amino acid hydroxylase family profile
Important for substrate binding and specificity
NAD(P) transhydrogenase alpha subunit C-terminal
6-phosphogluconate dehydrogenase C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Survival protein SurE-like phosphatase/nucleotidase
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Lytic transglycosylase superhelical linker
Choloylglycine hydrolase/NAAA C-terminal
Outer-membrane lipoprotein carrier protein
Ax21 family sulfation-dependent quorum factor
Aconitase A/isopropylmalate dehydratase small subunit swivel
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tryptophan synthase beta chain-like PALP
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Release factor glutamine methyltransferase N-terminal
Penicillin-binding protein transpeptidase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Ribosomal RNA adenine methylase transferase N-terminal
Solute-binding protein family 3/N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Putative type VI secretion system Rhs element associated Vgr
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Prepilin type IV endopeptidase peptidase
NIF system FeS cluster assembly NifU C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-92)
Glycosyl transferase family 3 N-terminal
Membrane-bound lytic murein transglycosylase A
Integral membrane protein YccS N-terminal
Alginate export domain-containing protein
Electron transfer via tryptophanyl radical
Reversibly protonated during proton transport
Thiamine pyrophosphate enzyme N-terminal TPP-binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Cysteine sulfenic acid (-SOH) intermediate
NADH:ubiquinone oxidoreductase 30kDa subunit
Transcription elongation factor GreA/GreB N-terminal
Endolytic peptidoglycan transglycosylase RlpA
Glutathionylspermidine synthase pre-ATP-grasp-like
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Chromosomal replication initiator DnaA C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Putative adhesin domain-containing protein
Phosphoethanolamine transferase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Chromosomal replication initiator protein DnaA
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Nicotinamide phosphoribosyltransferase N-terminal
Prokaryotic-type class I peptide chain release factors
Cation-transporting P-type ATPase N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
TRAP C4-dicarboxylate transport system permease DctM subunit
General stress protein FMN-binding split barrel
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL2 C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
PHA accumulation regulator DNA-binding N-terminal
Alanyl-transfer RNA synthetases family profile
Polysaccharide biosynthesis protein CapD-like
Acyl-CoA dehydrogenase C-terminal bacterial-type
Pyridine nucleotide-disulphide oxidoreductase dimerisation
DNA replication/recombination mediator RecO N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Pyruvate dehydrogenase E1 component middle
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
DNA-directed DNA polymerase family A palm
RNA binding; important for wobble base 34 recognition
Tetrahydrodipicolinate-N-succinyltransferase chain A
Translation elongation factor P/YeiP central
peptide-methionine (R)-S-oxide reductase
Disulphide bond isomerase DsbC/G N-terminal
Peptidase M1 membrane alanine aminopeptidase
ABC-type transport auxiliary lipoprotein component
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Lysozyme inhibitor LprI N-terminal domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Exonuclease VII large subunit C-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
TonB-dependent receptor plug domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Shikimate dehydrogenase substrate binding N-terminal
Flagella basal body P-ring formation protein FlgA
Autotransporter domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Cytochrome b561 bacterial/Ni-hydrogenase
Flagellar hook-length control protein-like C-terminal
Alpha-glycerophosphate oxidase C-terminal
Outer membrane protein assembly factor BamD
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Glucosamine/galactosamine-6-phosphate isomerase
YbaK/aminoacyl-tRNA synthetase-associated
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
SGNH hydrolase-type esterase domain-containing protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Required for zinc-mediated homotetramerization and catalytic activity
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Glycosyl-hydrolase 97 C-terminal oligomerisation
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Arginine decarboxylase C-terminal helical
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
TonB C-terminal domain-containing protein
Adaptive response protein AidB N-terminal
Proton acceptor; for glutaminase activity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Could be important to modulate the pK values of the two catalytic cysteine residues
Outer membrane protein assembly factor BamB
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Transglutaminase-like domain-containing protein
Bacterial NAD-glutamate dehydrogenase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Plays an important role in substrate specificity
Small ribosomal subunit protein uS4 N-terminal
Lantibiotic biosynthesis protein dehydration
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Thiol:disulfide interchange protein DsbA
Type II secretion system protein GspE N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Outer membrane lipoprotein carrier protein LolA
Ribose-phosphate pyrophosphokinase N-terminal
Plays an important role in discriminating NADH against NADPH
Carbamoyl-phosphate synthase small subunit N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Essential for prephenate dehydratase activity
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Acyl-CoA thioester hydrolase/bile acid acetyltransferase-like protein
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Threonine/serine exporter-like N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Mannose-6-phosphate isomerase type II C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Outer membrane protein assembly factor BamA
Beta-hexosaminidase bacterial type N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Trigger factor ribosome-binding bacterial
Gfo/Idh/MocA-like oxidoreductase C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
O-(phosphoribosyl dephospho-coenzyme A)serine
Pseudouridine synthase I TruA alpha/beta
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glycine cleavage T-protein C-terminal barrel
Gly-cisPro motif, important for rejection of L-amino acids
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Anthranilate synthase component I N-terminal
Important for interaction with partner proteins
3-keto-disaccharide hydrolase domain-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Tail specific protease domain-containing protein
Proline utilization A proline dehydrogenase N-terminal
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor