Solute-binding protein family 3/N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Required for dimer formation and molybdate binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Bacterial type II secretion system protein E
RNA polymerase sigma factor 70 region 4 type 2
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Essential for prephenate dehydratase activity
O-(3'-phospho-DNA)-tyrosine intermediate
NIF system FeS cluster assembly NifU C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Prokaryotic-type class I peptide chain release factors
Cytochrome b561 bacterial/Ni-hydrogenase
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Major facilitator superfamily (MFS) profile
Cob(I)alamin adenosyltransferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Seems to be a necessary countercharge to the potassium cations
S-adenosylmethionine-dependent methyltransferase
Acyl-CoA dehydrogenase/oxidase N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Lysozyme inhibitor LprI N-terminal domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
O-(5'-phospho-DNA)-tyrosine intermediate
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Anthranilate synthase component I N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
ABC-type glycine betaine transport system substrate-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Inner membrane protein YgaP-like transmembrane
Alpha-glycerophosphate oxidase C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
RND efflux pump membrane fusion protein barrel-sandwich
Erythronate-4-phosphate dehydrogenase dimerisation
Alanyl-transfer RNA synthetases family profile
Membrane fusion protein biotin-lipoyl like
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
Shikimate dehydrogenase substrate binding N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Outer membrane protein assembly factor BamA
Molybdopterin cofactor biosynthesis C (MoaC)
Peptidase S9 prolyl oligopeptidase catalytic
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Penicillin-binding protein transpeptidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA topoisomerase I catalytic core eukaryotic-type
Mandelate racemase/muconate lactonizing enzyme C-terminal
Transcription elongation factor GreA/GreB C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Schiff-base intermediate with acetaldehyde
Prepilin type IV endopeptidase peptidase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RNA 2-O ribose methyltransferase substrate binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Polymerase/histidinol phosphatase N-terminal
TonB-dependent receptor-like beta-barrel
Endolytic peptidoglycan transglycosylase RlpA
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
RlpA-like protein double-psi beta-barrel
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Interaction with polymerase core subunit RpoC
Release factor glutamine methyltransferase N-terminal
Glycosyl transferase family 3 N-terminal
Saccharopine dehydrogenase-like C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Pyruvate dehydrogenase E1 component middle
DNA replication/recombination mediator RecO N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Tc toxin complex TcA C-terminal TcB-binding
Lytic transglycosylase superhelical linker
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Acyl-CoA dehydrogenase/oxidase C-terminal
DNA polymerase III subunit delta C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Polysaccharide chain length determinant N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Acyl-CoA dehydrogenase C-terminal bacterial-type
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Thymidylate synthase/dCMP hydroxymethylase
Flagellar hook-length control protein-like C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
ABC-type transport auxiliary lipoprotein component
NADH-rubredoxin oxidoreductase C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
NAD(P) transhydrogenase alpha subunit C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Peptide methionine sulphoxide reductase MsrA
Polyribonucleotide nucleotidyltransferase
DNA polymerase III delta subunit C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Moves into active site upon enzyme activation, plays a role in electron transfer
Sodium/calcium exchanger membrane region
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Tryptophan synthase beta chain-like PALP
Chromosomal replication initiator protein DnaA
Ionotropic glutamate receptor C-terminal
Flagellar motor switch protein FliN-like C-terminal
Electron transfer via tryptophanyl radical
Glucose-methanol-choline oxidoreductase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Helix-hairpin-helix DNA-binding motif class 1
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Gamma-butyrobetaine hydroxylase-like N-terminal
Translation elongation factor P/YeiP central
Organic solvent tolerance-like N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ribosomal RNA small subunit methyltransferase E methyltransferase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
HicB-like antitoxin of toxin-antitoxin system
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Translocation and assembly module subunit TamA
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Large exoproteins involved in heme utilization or adhesion
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Phosphoethanolamine transferase N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Heme-copper oxidase subunit III family profile
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Bacteriophage tail tape measure C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Mannose-6-phosphate isomerase type II C-terminal
Positions MEP for the nucleophilic attack
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Thiol:disulfide interchange protein DsbD
Large ribosomal subunit protein uL15/eL18
DNA mismatch repair proteins mutS family
Fimbrial-type adhesion domain-containing protein
Important for substrate binding and specificity
6-phosphogluconate dehydrogenase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
TRAP C4-dicarboxylate transport system permease DctM subunit
Carbamoyl-phosphate synthase small subunit N-terminal
Chromosomal replication initiator DnaA C-terminal
Glycine cleavage T-protein C-terminal barrel
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Gly-cisPro motif, important for rejection of L-amino acids
ATP synthase F1 complex delta/epsilon subunit N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Bacterial bifunctional deaminase-reductase C-terminal
Water stress and hypersensitive response
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Outer-membrane lipoprotein carrier protein
Solute-binding protein family 5 domain-containing protein
High-affinity zinc uptake system protein ZnuA
Quorum-sensing-regulated virulence factor
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Putative regulatory protein FmdB Zinc ribbon
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Interacts with tRNA; defines subfamily-specific binding signature
Survival protein SurE-like phosphatase/nucleotidase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Putative beta-barrel assembly-enhancing protease
DNA-directed DNA polymerase family A palm
Transposase IS204/IS1001/IS1096/IS1165 DDE
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein uL6 alpha-beta
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Guanylate kinase/L-type calcium channel beta subunit
Pyrimidine nucleoside phosphorylase C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Glucose-methanol-choline oxidoreductase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Inosine/uridine-preferring nucleoside hydrolase
NIF system FeS cluster assembly NifU N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Plays an important role in substrate specificity
Pyruvate phosphate dikinase AMP/ATP-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Transcription elongation factor GreA/GreB N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Important for interaction with partner proteins
Superoxide dismutase copper/zinc binding
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase N-terminal
Integral membrane protein YccS N-terminal
Mechanosensitive ion channel inner membrane
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
YbaK/aminoacyl-tRNA synthetase-associated
Glucan biosynthesis periplasmic MdoG C-terminal
Proline utilization A proline dehydrogenase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Small ribosomal subunit protein uS4 N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Disulphide bond isomerase DsbC/G N-terminal
4'-phosphopantetheinyl transferase N-terminal
Sugar fermentation stimulation protein C-terminal
Arginine decarboxylase C-terminal helical
Flagellar assembly protein FliH/Type III secretion system HrpE
Signal transduction histidine kinase internal region
Type III secretion system flagellar brake protein YcgR PilZN
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Lipopolysaccharide export system protein LptA
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Glucosamine/galactosamine-6-phosphate isomerase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Ribose-phosphate pyrophosphokinase N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
N-end rule aminoacyl transferase C-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Ribosomal RNA adenine methylase transferase N-terminal
Increases nucleophilicity of active site Cys
Polysaccharide biosynthesis protein CapD-like
DNA-3-methyladenine glycosylase AlkA N-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
ABC transporter substrate-binding protein PnrA-like
Sulfatase-modifying factor enzyme domain-containing protein
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Outer-membrane lipoprotein Wza C-terminal
PhoD-like phosphatase metallophosphatase
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal