3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Transposase IS116/IS110/IS902 C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
UDP N-acetylglucosamine O-acyltransferase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Major facilitator superfamily (MFS) profile
Pyridoxamine 5'-phosphate oxidase putative
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Mandelate racemase/muconate lactonizing enzyme C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyrroline-5-carboxylate reductase catalytic N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Resuscitation-promoting factor core lysozyme-like
O-(3'-phospho-DNA)-tyrosine intermediate
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Tryptophan synthase beta chain-like PALP
6-phosphogluconate dehydrogenase NADP-binding
Cell envelope-related transcriptional attenuator
Peptidase M1 membrane alanine aminopeptidase
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Anti-sigma-D factor RsdA sigma factor binding region
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Putative regulatory protein FmdB Zinc ribbon
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Actinobacteria/chloroflexi VLRF1 release factor
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Membrane insertase YidC/Oxa/ALB C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Myo-inositol-1-phosphate synthase GAPDH-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
RNA polymerase sigma factor 70 region 4 type 2
Gly-cisPro motif, important for rejection of L-amino acids
O-(5'-phospho-DNA)-tyrosine intermediate
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Glycine cleavage T-protein C-terminal barrel
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Gfo/Idh/MocA-like oxidoreductase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
ABC-type glycine betaine transport system substrate-binding
Prokaryotic-type class I peptide chain release factors
Transition state stabilizer; via amide nitrogen
Glycosyltransferase family 28 N-terminal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Glycoside hydrolase family 42 N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Inosine/uridine-preferring nucleoside hydrolase
Glycosyl transferase family 28 C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
S-adenosyl-L-homocysteine hydrolase NAD binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Thiamine pyrophosphate enzyme TPP-binding
Helix-hairpin-helix DNA-binding motif class 1
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Phosphocysteine intermediate; for EIIB activity
Exonuclease VII large subunit C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidoglycan recognition protein family
Transcription regulator AsnC/Lrp ligand binding
3-beta hydroxysteroid dehydrogenase/isomerase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Putative oxidoreductase/dehydrogenase Rossmann-like
Erythromycin biosynthesis protein CIII-like central
Heat-inducible transcription repressor HrcA C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Phosphotransferase system enzyme I N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
PhoD-like phosphatase metallophosphatase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
YbaK/aminoacyl-tRNA synthetase-associated
Cell wall-active antibiotics response LiaF-like C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Penicillin-binding protein transpeptidase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
PknH-like extracellular domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Cytochrome C biogenesis protein transmembrane
6-phosphogluconate dehydrogenase C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Cobalamin-independent methionine synthase MetE N-terminal
Thiopeptide-type bacteriocin biosynthesis
Proton acceptor; for glutaminase activity
NADH:ubiquinone oxidoreductase 30kDa subunit
Butirosin biosynthesis protein H N-terminal
Plays an important role in substrate specificity
Sodium/calcium exchanger membrane region
ATP synthase F1 complex delta/epsilon subunit N-terminal
Membrane fusion protein biotin-lipoyl like
CDP-alcohol phosphatidyltransferase C-terminal
phosphoenolpyruvate--glycerone phosphotransferase
DnaJ homologue subfamily C member 28 conserved
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Polymerase/histidinol phosphatase N-terminal
Beta-hexosaminidase bacterial type N-terminal
RNA 2-O ribose methyltransferase substrate binding
DNA primase/polymerase bifunctional N-terminal
Alpha galactosidase C-terminal beta sandwich
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Microcin J25-processing protein McjB C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Allene oxide cyclase barrel-like domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
DNA replication/recombination mediator RecO N-terminal
Reversibly protonated during proton transport
Glucosamine/galactosamine-6-phosphate isomerase
Peptide methionine sulphoxide reductase MsrA
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Gamma-glutamylcyclotransferase AIG2-like
Phosphoadenosine phosphosulphate reductase
SUF system FeS cluster assembly SufBD N-terminal
Glycosyl transferase family 3 N-terminal
Bacterial type II secretion system protein E
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
SD-repeat containing protein B domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Solute-binding protein family 3/N-terminal
Small ribosomal subunit protein uS4 N-terminal
Sporulation transcription regulator WhiA N-terminal
Methionyl-tRNA synthetase anticodon-binding
DNA-binding beta-propeller fold protein YncE
Prepilin type IV endopeptidase peptidase
NIF system FeS cluster assembly NifU C-terminal
Large ribosomal subunit protein uL2 C-terminal
Tat pathway signal sequence domain protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Histidine-specific methyltransferase SAM-dependent
Polymerase/histidinol phosphatase N-terminal domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycosyl-hydrolase 97 C-terminal oligomerisation
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Large ribosomal subunit protein uL6 alpha-beta
Pyrimidine nucleoside phosphorylase C-terminal
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity
Nicotinate phosphoribosyltransferase N-terminal
Endonuclease/Exonuclease/phosphatase family protein
Superoxide dismutase copper/zinc binding
Carboxypeptidase regulatory-like domain-containing protein
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Large ribosomal subunit protein uL15/eL18
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Essential for prephenate dehydratase activity
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Removed in mature form; by autocatalysis
Pyruvate dehydrogenase E1 component middle
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Putative glycogen debranching enzyme N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Phosphoribosylformylglycinamidine synthase linker
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Cytochrome b/b6 N-terminal region profile
Lactate utilization protein B C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Positions MEP for the nucleophilic attack
Na+/H+ antiporter MnhB subunit-related protein
Ionotropic glutamate receptor C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Phosphomannose isomerase type I catalytic
Fibronectin type-III domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Type I restriction modification DNA specificity
Could play a key role in the communication between the regulatory and the substrate sites
Alpha-L-arabinofuranosidase B arabinose-binding
Chromosomal replication initiator DnaA C-terminal
Lantibiotic biosynthesis protein dehydration
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alanyl-transfer RNA synthetases family profile
Nucleophile; cysteine thiosulfonate intermediate
NIF system FeS cluster assembly NifU N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Restriction endonuclease AspBHI N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Centromere-binding protein ParB C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Translation elongation factor P/YeiP central