Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Major facilitator superfamily (MFS) profile
Schiff-base intermediate with D-ribose 5-phosphate
Streptomyces killer toxin-like beta/gamma crystallin
Ricin B lectin domain-containing protein
Peptidase C39-like domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Glycosyl transferase family 28 C-terminal
Important for beta-aspartyl-AMP intermediate formation
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Plays an important role in substrate specificity
PhoD-like phosphatase metallophosphatase
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Peptidase S9 prolyl oligopeptidase catalytic
Solute-binding protein family 3/N-terminal
Polymerase/histidinol phosphatase N-terminal
Resuscitation-promoting factor core lysozyme-like
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Activator of Hsp90 ATPase homologue 1-like C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Glucose-methanol-choline oxidoreductase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyridoxamine 5'-phosphate oxidase putative
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Exonuclease VII large subunit C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
DNA replication/recombination mediator RecO N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Molybdenum cofactor biosynthesis protein F N-terminal
Butirosin biosynthesis protein H N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cell envelope-related transcriptional attenuator
Glucose-methanol-choline oxidoreductase N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Anti-sigma-D factor RsdA sigma factor binding region
Transcription regulator AsnC/Lrp ligand binding
Penicillin-binding protein transpeptidase
Ribosomal RNA adenine methylase transferase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Urease accessory protein UreH-like transmembrane
DNA-directed DNA polymerase family A palm
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphoadenosine phosphosulphate reductase
2,4-diaminopentanoate dehydrogenase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Prokaryotic-type class I peptide chain release factors
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Resolvase/invertase-type recombinase catalytic
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Prepilin type IV endopeptidase peptidase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Actinobacteria/chloroflexi VLRF1 release factor
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyruvate dehydrogenase E1 component middle
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Glycosyltransferase family 28 N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Glycosyl transferase family 3 N-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Alpha-L-arabinofuranosidase B arabinose-binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Involved in ionization of N3 of dUMP, leading to its activation
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Putative regulatory protein FmdB Zinc ribbon
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythromycin biosynthesis protein CIII-like central
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NIF system FeS cluster assembly NifU N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Peptidase M1 membrane alanine aminopeptidase
Alpha-D-phosphohexomutase alpha/beta/alpha
Alanyl-transfer RNA synthetases family profile
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Blue (type 1) copper domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Lantibiotic biosynthesis protein dehydration
Prealbumin-like fold domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Schiff-base intermediate with substrate; via pyruvic acid
vWA-MoxR associated protein middle region 0
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Myo-inositol-1-phosphate synthase GAPDH-like
6-phosphogluconate dehydrogenase C-terminal
Large ribosomal subunit protein uL2 C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Acetyl-CoA hydrolase/transferase C-terminal
Protein O-mannosyl-transferase C-terminal four TM
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Transglycosylase SLT domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
DnaJ homologue subfamily C member 28 conserved
Formamidopyrimidine-DNA glycosylase catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Nucleophile; cysteine thiosulfonate intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Ribosome maturation factor RimP N-terminal
ABC-type glycine betaine transport system substrate-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Endoribonuclease L-PSP/chorismate mutase-like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
PLD phosphodiesterase domain-containing protein
Solute-binding protein family 5 domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Interaction with polymerase core subunit RpoC
Glucose/Sorbosone dehydrogenase domain-containing protein
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Histidine-specific methyltransferase SAM-dependent
Schiff-base intermediate with substrate; via topaquinone
Alpha-glycerophosphate oxidase C-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Survival protein SurE-like phosphatase/nucleotidase
Cytochrome c-type biogenesis protein CcmF C-terminal
Small ribosomal subunit protein uS4 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Aconitase A/isopropylmalate dehydratase small subunit swivel
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Removed in mature form; by autocatalysis
L,D-transpeptidase catalytic domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Aminopeptidase N-like N-terminal domain-containing protein
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Release factor glutamine methyltransferase N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycine cleavage T-protein C-terminal barrel
Sugar ABC transporter periplasmic protein
Reversibly protonated during proton transport
Peptide methionine sulphoxide reductase MsrA
O-(3'-phospho-DNA)-tyrosine intermediate
Tetracyclin repressor-like C-terminal group 31
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Phosphotransferase system enzyme I N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Sporulation transcription regulator WhiA N-terminal
Cytochrome C biogenesis protein transmembrane
Cobalamin-independent methionine synthase MetE N-terminal
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Heme-copper oxidase subunit III family profile
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glucosamine/galactosamine-6-phosphate isomerase
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Adaptive response protein AidB N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyrimidine nucleoside phosphorylase C-terminal
Bacterial type II secretion system protein E
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Putative Flp pilus-assembly TadG-like N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Translation elongation factor P/YeiP central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Polysaccharide biosynthesis protein CapD-like
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-114)
Proton acceptor; for glutaminase activity
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Quinolinate phosphoribosyl transferase N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Ionotropic glutamate receptor C-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Putative oxidoreductase/dehydrogenase Rossmann-like
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Essential for prephenate dehydratase activity
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Acetylserotonin O-methyltransferase dimerisation
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Sodium/calcium exchanger membrane region
Peptidase S8/S53 domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
Styrene monooxygenase StyA putative substrate binding
DNA primase/polymerase bifunctional N-terminal
ABC transporter substrate-binding protein PnrA-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Transcriptional regulator LacI/GalR-like sensor
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
FAD-binding PCMH-type domain-containing protein
Large ribosomal subunit protein uL15/eL18
Cellulase Ig-like domain-containing protein
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
ATP-dependent DNA helicase RecG C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC