Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Aminoacyl-transfer RNA synthetases class-II family profile
Polymerase/histidinol phosphatase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Nicotinate phosphoribosyltransferase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Copper resistance protein D domain-containing protein
Cell envelope-related transcriptional attenuator
RNA polymerase sigma factor 70 region 4 type 2
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pseudouridine synthase I TruA alpha/beta
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Alanyl-transfer RNA synthetases family profile
Proton acceptor; for glutaminase activity
Pyrimidine nucleoside phosphorylase C-terminal
Phosphomannose isomerase type I catalytic
Mycothiol-dependent maleylpyruvate isomerase metal-binding
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Major facilitator superfamily (MFS) profile
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Acyltransferase MbtK/IucB-like conserved
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-103)
Solute-binding protein family 3/N-terminal
Release factor glutamine methyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase M1 membrane alanine aminopeptidase
Transcription regulator AsnC/Lrp ligand binding
Formamidopyrimidine-DNA glycosylase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Schiff-base intermediate with D-ribose 5-phosphate
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycosyltransferase subfamily 4-like N-terminal
Type II secretion system protein GspF domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
NADH:ubiquinone oxidoreductase 30kDa subunit
PhoD-like phosphatase metallophosphatase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Endoribonuclease L-PSP/chorismate mutase-like
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Essential for prephenate dehydratase activity
Peptide methionine sulphoxide reductase MsrA
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Nitrite/Sulfite reductase ferredoxin-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Peptidase C39-like domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Phosphotransferase system enzyme I N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glucosamine/galactosamine-6-phosphate isomerase
Cell wall-active antibiotics response LiaF-like C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alpha-glycerophosphate oxidase C-terminal
Tryptophan synthase beta chain-like PALP
ABC-type glycine betaine transport system substrate-binding
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycosyl transferase family 3 N-terminal
NIF system FeS cluster assembly NifU N-terminal
Chromosomal replication initiator DnaA C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Membrane insertase YidC/Oxa/ALB C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Peptidase S8/S53 domain-containing protein
Squalene cyclase C-terminal domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Sporulation transcription regulator WhiA N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Penicillin-binding protein transpeptidase
DnaJ homologue subfamily C member 28 conserved
Na+/H+ antiporter MnhB subunit-related protein
Reversibly protonated during proton transport
O-(3'-phospho-DNA)-tyrosine intermediate
Homogentisate 1,2-dioxygenase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Pyruvate dehydrogenase E1 component middle
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Bacterial Ig-like domain-containing protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module domain-containing protein
YbaK/aminoacyl-tRNA synthetase-associated
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Large ribosomal subunit protein uL15/eL18
Phosphoadenosine phosphosulphate reductase
Removed in mature form; by autocatalysis
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Heat-inducible transcription repressor HrcA C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Translation elongation factor P/YeiP central
Ionotropic glutamate receptor C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
N-acetylneuraminic acid synthase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Prokaryotic-type class I peptide chain release factors
DNA topoisomerase I catalytic core eukaryotic-type
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
PsbP C-terminal domain-containing protein
Fibrinogen C-terminal domain-containing protein
Exonuclease VII large subunit C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptidase M14 carboxypeptidase A domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Erythromycin biosynthesis protein CIII-like central
ABC transporter substrate-binding protein
DNA replication/recombination mediator RecO N-terminal
6-phosphogluconate dehydrogenase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
General stress protein FMN-binding split barrel
AB hydrolase-1 domain-containing protein
CobB/CobQ-like glutamine amidotransferase
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Saccharopine dehydrogenase-like C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
NADH-rubredoxin oxidoreductase C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Methionyl-tRNA synthetase anticodon-binding
Putative oxidoreductase/dehydrogenase Rossmann-like
Activator of Hsp90 ATPase homologue 1-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
ABC transporter-associated repeat protein
Plays an important role in substrate specificity
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Positions MEP for the nucleophilic attack
PPIase cyclophilin-type domain-containing protein
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Important for substrate specificity; cannot use PPi as phosphoryl donor
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Thymidylate synthase/dCMP hydroxymethylase
Cytochrome b/b6 N-terminal region profile
Carbamoyl-phosphate synthase small subunit N-terminal
Bacterial type II secretion system protein E
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Solute-binding protein family 3/N-terminal domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Glycine cleavage T-protein C-terminal barrel
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Fibronectin type-III domain-containing protein
TRAP C4-dicarboxylate transport system permease DctM subunit
SUF system FeS cluster assembly SufBD N-terminal