3-isopropylmalate dehydratase large subunit
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
RNA polymerase sigma factor 70 region 4 type 2
Iron-sulfur cluster insertion protein ErpA
Carbamoyl-phosphate synthase small subunit N-terminal
Protein-glutamate methylesterase/protein-glutamine glutaminase 2
RNA 2-O ribose methyltransferase substrate binding
Involved in allosteric activation by GTP
BREX system Lon protease-like BrxL N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
PEP-CTERM protein-sorting domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Outer membrane protein beta-barrel domain-containing protein
Glycosyltransferase subfamily 4-like N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Cyclic pyranopterin monophosphate synthase
TonB-dependent receptor-like beta-barrel
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Pyruvate dehydrogenase E1 component middle
AMP-activated protein kinase glycogen-binding
Important for beta-aspartyl-AMP intermediate formation
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
CD-NTase associated protein 4-like DNA endonuclease
Leucyl/phenylalanyl-tRNA--protein transferase
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Alpha-D-phosphohexomutase alpha/beta/alpha
Ribosomal RNA small subunit methyltransferase H
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Solute-binding protein family 3/N-terminal
Alginate lyase domain-containing protein
Arginine decarboxylase C-terminal helical
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Polymerase/histidinol phosphatase N-terminal
RNA binding; important for wobble base 34 recognition
Ribosomal RNA large subunit methyltransferase F
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Prepilin type IV endopeptidase peptidase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
NADPH-dependent 7-cyano-7-deazaguanine reductase
Resolvase/invertase-type recombinase catalytic
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Polysaccharide chain length determinant N-terminal
Major facilitator superfamily (MFS) profile
3-methyl-2-oxobutanoate hydroxymethyltransferase
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
3-isopropylmalate dehydratase small subunit
Right handed beta helix domain-containing protein
DNA-directed RNA polymerase subunit beta'
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Peptidase M61 catalytic domain-containing protein
Heme-copper oxidase subunit III family profile
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
SUF system FeS cluster assembly SufBD N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Arabinogalactan endo-beta-1,4-galactanase
Acyl-CoA dehydrogenase/oxidase N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
4-hydroxythreonine-4-phosphate dehydrogenase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ribosomal RNA large subunit methyltransferase K/L
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Outer membrane protein assembly factor BamA
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Pullulanase carbohydrate-binding module 41
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
Interaction with polymerase core subunit RpoC
5-methylthioadenosine/S-adenosylhomocysteine deaminase
S-adenosylmethionine:tRNA ribosyltransferase-isomerase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
Mannan-binding protein domain-containing protein
TonB C-terminal domain-containing protein
Ribosomal RNA large subunit methyltransferase H
RND efflux pump membrane fusion protein barrel-sandwich
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NAD(P) transhydrogenase alpha subunit C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Lysozyme inhibitor LprI N-terminal domain-containing protein
DNA-directed RNA polymerase subunit beta
Contractile injection system tube protein N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Peptidase S9 prolyl oligopeptidase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
Extracellular exo-alpha-(1->5)-L-arabinofuranosidase
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical
Gly-cisPro motif, important for rejection of L-amino acids
Dual-specificity RNA methyltransferase RlmN
DNA-directed DNA polymerase family A palm
Plays an important role in substrate specificity
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Interacts with tRNA; defines subfamily-specific binding signature
Flagellar hook-basal body complex protein FliE
Activator of Hsp90 ATPase homologue 1-like C-terminal
Biotin biosynthesis bifunctional protein BioHC
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Carboxypeptidase regulatory-like domain-containing protein
Type II secretion system protein GspI C-terminal
Oxygen-dependent coproporphyrinogen-III oxidase
Membrane fusion protein biotin-lipoyl like
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Outer membrane lipoprotein-sorting protein
Ribosomal RNA large subunit methyltransferase M
Transcriptional regulator LacI/GalR-like sensor
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Pyridoxamine 5'-phosphate oxidase putative
Type III secretion system flagellar brake protein YcgR PilZN
Carboxy-S-adenosyl-L-methionine synthase
Gamma-butyrobetaine hydroxylase-like N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Tryptophan synthase beta chain-like PALP
Cellulose-binding Sde182 nucleoside hydrolase-like
Cellulose-binding Sde182 nucleoside hydrolase-like domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Protein-glutamate methylesterase/protein-glutamine glutaminase 1
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Precorrin-2 dehydrogenase /sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Bacterial surface antigen (D15) domain-containing protein
Urease accessory protein UreH-like transmembrane
Glycosyl-hydrolase 97 C-terminal oligomerisation
Probable nicotinate-nucleotide adenylyltransferase
Solute-binding protein family 3/N-terminal domain-containing protein
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
UDP-N-acetylmuramoylalanine--D-glutamate ligase
DNA polymerase III subunit delta C-terminal
Ribosomal RNA small subunit methyltransferase J
Ribosomal RNA small subunit methyltransferase A
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Pseudouridine synthase I TruA alpha/beta
Phosphate ABC transporter substrate-binding protein
Glutamate-1-semialdehyde 2,1-aminomutase
Enoyl-[acyl-carrier-protein] reductase [NADH]
Plays an important role in discriminating NADH against NADPH
Ribosomal RNA large subunit methyltransferase E
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Carbohydrate esterase 2 N-terminal domain-containing protein
Penicillin-binding protein transpeptidase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Succinate--CoA ligase [ADP-forming] subunit beta
Mandelate racemase/muconate lactonizing enzyme C-terminal
Probable transcriptional regulatory protein Sde_1551
High frequency lysogenization protein HflD homolog
3-octaprenyl-4-hydroxybenzoate carboxy-lyase
tRNA N6-adenosine threonylcarbamoyltransferase
Imidazole glycerol phosphate synthase subunit HisF
Polysaccharide biosynthesis protein C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Putative regulatory protein FmdB Zinc ribbon
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Disulphide bond isomerase DsbC/G N-terminal
4-hydroxy-tetrahydrodipicolinate synthase
Outer membrane protein OmpA-like transmembrane
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Thiol:disulfide interchange protein DsbA
Gp5/Type VI secretion system Vgr protein OB-fold
Sodium symporter small subunit predicted
Pectate lyase superfamily protein domain-containing protein
Bacterial virulence factor lipase N-terminal domain-containing protein
Putative pterin-4-alpha-carbinolamine dehydratase
Rap1a immunity protein domain-containing protein
Cyclic nucleotide-binding domain-containing protein
Pyrimidine/purine nucleoside phosphorylase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Water stress and hypersensitive response
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
ExoP galactose-binding-like domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
Sodium/calcium exchanger membrane region
Bacterial type II secretion system protein E
Penicillin-insensitive murein endopeptidase
Twin-arginine translocation pathway signal
Cell wall-active antibiotics response LiaF-like C-terminal
Lipoprotein-releasing system ATP-binding protein LolD
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glutamyl-tRNA(Gln) amidotransferase subunit A
6-phosphogluconate dehydrogenase C-terminal
Crossover junction endodeoxyribonuclease RuvC
Beta-xylosidase C-terminal Concanavalin A-like
Mannose-6-phosphate isomerase type II C-terminal
Putative auto-transporter adhesin head GIN
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Sec-independent protein translocase protein TatB
FMN-dependent NADH:quinone oxidoreductase
Sugar fermentation stimulation protein homolog
Flagellar motor switch protein FliN-like C-terminal
Lipoprotein SmpA/OmlA domain-containing protein
RNA methyltransferase SpoU/TrmH type C-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
DNA polymerase III delta subunit C-terminal
Reversibly protonated during proton transport
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Bacterial transcription activator effector binding
Electron transfer via tryptophanyl radical
Flagellar hook-length control protein-like C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
3-deoxy-manno-octulosonate cytidylyltransferase
Cytochrome c-type biogenesis protein CcmF C-terminal
ATP-dependent protease ATPase subunit HslU
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
TtsA-like Glycoside hydrolase family 108
N-acetyl-gamma-glutamyl-phosphate reductase
C-type lysozyme inhibitor domain-containing protein
4'-phosphopantetheinyl transferase N-terminal
Holliday junction branch migration complex subunit RuvA
4-hydroxy-tetrahydrodipicolinate reductase
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Anthranilate synthase component I N-terminal
Phenylalanine--tRNA ligase alpha subunit
Peptide methionine sulfoxide reductase MsrA
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
UDP-3-O-acyl-N-acetylglucosamine deacetylase
Peptide methionine sulfoxide reductase MsrB
Alpha galactosidase C-terminal beta sandwich
Could be important to modulate the pK values of the two catalytic cysteine residues
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Cytochrome b561 bacterial/Ni-hydrogenase
UDP-3-O-acylglucosamine N-acyltransferase
Important for interaction with partner proteins
Small-conductance mechanosensitive channel
Exonuclease VII large subunit C-terminal
Cadherin-like beta sandwich domain-containing protein
Gamma-glutamylcyclotransferase AIG2-like
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
S-adenosylmethionine-dependent methyltransferase
Prokaryotic-type class I peptide chain release factors
Proton acceptor; for glutaminase activity
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Signal transduction histidine kinase internal region
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Small ribosomal subunit biogenesis GTPase RsgA
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glycosyl hydrolase family 30 beta sandwich
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
DNA-directed RNA polymerase subunit omega
3-keto-disaccharide hydrolase domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
ATP phosphoribosyltransferase regulatory subunit
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Lysidine-tRNA(Ile) synthetase C-terminal
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC
Saccharopine dehydrogenase-like C-terminal
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-104)
tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Na(+)-translocating NADH-quinone reductase subunit A
ATP-dependent Clp protease ATP-binding subunit ClpX
Major facilitator superfamily associated
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
PhoD-like phosphatase metallophosphatase
Histidine-specific methyltransferase SAM-dependent
Type II secretion system protein GspC N-terminal
Magnesium transporter MgtE intracellular
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Holliday junction branch migration complex subunit RuvB
Ubiquinone biosynthesis O-methyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
1000-fold decrease in catalytic activity.
1600-fold decrease in catalytic efficiency.
20-fold decrease in catalytic efficiency.
2000-fold decrease in catalytic efficiency.
4400-fold decrease in catalytic efficiency.
Neutralizes the sugar carboxylate group at subsite +1
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Flagellar assembly protein FliH/Type III secretion system HrpE
tRNA/tmRNA (uracil-C(5))-methyltransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Molybdenum import ATP-binding protein ModC
Type II secretion system protein GspG C-terminal
DNA-directed RNA polymerase subunit alpha
Probable chemoreceptor glutamine deamidase CheD
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Chromosomal replication initiator protein DnaA
Phosphoribosylformylglycinamidine cyclo-ligase
tRNA (cytidine(34)-2'-O)-methyltransferase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
ATP-dependent Clp protease proteolytic subunit
Transcription antitermination protein NusB
Chitobiase/beta-hexosaminidases N-terminal
Sec-independent protein translocase protein TatA
Outer membrane protein assembly factor BamD
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Na(+)-translocating NADH-quinone reductase subunit E
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Cytochrome c-type biogenesis protein CcmE
Helical; Signal-anchor for type II membrane protein
Phosphoribosylaminoimidazole-succinocarboxamide synthase
Poly-beta-hydroxybutyrate polymerase N-terminal
Type VI secretion system IcmF C-terminal