Cytochrome C biogenesis protein transmembrane
Probable transposase IS891/IS1136/IS1341
LPXTG cell wall anchor domain-containing protein
Major facilitator superfamily (MFS) profile
Solute-binding protein family 3/N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Phosphocysteine intermediate; for EIIB activity
Prokaryotic-type class I peptide chain release factors
Erythromycin biosynthesis protein CIII-like central
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Cell envelope-related transcriptional attenuator
Pyridoxamine 5'-phosphate oxidase putative
Tryptophan synthase beta chain-like PALP
RNA polymerase sigma factor 70 region 4 type 2
Nicotinate phosphoribosyltransferase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Positions MEP for the nucleophilic attack
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Alanyl-transfer RNA synthetases family profile
Bacterial type II secretion system protein E
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Methionyl-tRNA synthetase anticodon-binding
PhoD-like phosphatase metallophosphatase
Pyruvate phosphate dikinase AMP/ATP-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Beta-hexosaminidase bacterial type N-terminal
Glycoamylase-like domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycosyl transferase family 3 N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
CobB/CobQ-like glutamine amidotransferase
ABC transporter substrate-binding protein PnrA-like
Cytochrome oxidase subunit II copper A binding
Peptidase S9 prolyl oligopeptidase catalytic
Release factor glutamine methyltransferase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Penicillin-binding protein transpeptidase
ABC-type glycine betaine transport system substrate-binding
6-phosphogluconate dehydrogenase NADP-binding
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Glycosyltransferase subfamily 4-like N-terminal
Sodium/calcium exchanger membrane region
Signal recognition particle SRP54 helical bundle
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Transglycosylase SLT domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycine cleavage T-protein C-terminal barrel
Increases nucleophilicity of active site Cys
DNA primase/polymerase bifunctional N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Peptidase C39-like domain-containing protein
Putative glycogen debranching enzyme N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
YbaK/aminoacyl-tRNA synthetase-associated
Glutathionylspermidine synthase pre-ATP-grasp-like
Glycerophosphoryl diester phosphodiesterase family protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pseudouridine synthase I TruA alpha/beta
Bacterial bifunctional deaminase-reductase C-terminal
Cytochrome b/b6 N-terminal region profile
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Polysaccharide chain length determinant N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Involved in allosteric activation by GTP
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Endoribonuclease L-PSP/chorismate mutase-like
Proton acceptor; for glutaminase activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Protein O-mannosyl-transferase C-terminal four TM
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphatidic acid phosphatase type 2/haloperoxidase
Sporulation transcription regulator WhiA N-terminal
L-glutamine:2-deoxy-scyllo-inosose aminotransferase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Acyltransferase MbtK/IucB-like conserved
SUF system FeS cluster assembly SufBD N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Alpha-glycerophosphate oxidase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Leucine-binding protein domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
RlpA-like protein double-psi beta-barrel
RlpA-like protein double-psi beta-barrel domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Acetylserotonin O-methyltransferase dimerisation
Gram-positive cocci surface proteins LPxTG
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Interaction with polymerase core subunit RpoC
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Glucosamine/galactosamine-6-phosphate isomerase
6-phosphogluconate dehydrogenase C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Gamma-glutamylcyclotransferase AIG2-like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Nitrite/Sulfite reductase ferredoxin-like
Removed in mature form; by autocatalysis
Pyrroline-5-carboxylate reductase catalytic N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Gp5/Type VI secretion system Vgr protein OB-fold
MmyB-like transcription regulator ligand binding
Peptidase M1 membrane alanine aminopeptidase
N6 adenine-specific DNA methyltransferase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cation-transporting P-type ATPase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
N,N-dimethylformamidase beta subunit-like C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Chromosomal replication initiator DnaA C-terminal
Translation elongation factor EFTu/EF1A C-terminal
SMODS-associating 2TM beta-strand rich effector
Adaptive response protein AidB N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Mandelate racemase/muconate lactonizing enzyme C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Myo-inositol-1-phosphate synthase GAPDH-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
DNA replication/recombination mediator RecO N-terminal
Plays an important role in substrate specificity
Molybdopterin cofactor biosynthesis C (MoaC)
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
O-(5'-phospho-DNA)-tyrosine intermediate
Histidine-specific methyltransferase SAM-dependent
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Phosphotransferase system enzyme I N-terminal
Fibronectin type-III domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Lactate utilization protein B C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Probable subtilase-type protease inhibitor
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Exonuclease VII large subunit C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alpha-D-phosphohexomutase alpha/beta/alpha
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ricin B lectin domain-containing protein
2'-deamino-2'-hydroxyneamine transaminase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Cysteine sulfenic acid (-SOH) intermediate
Thiopeptide-type bacteriocin biosynthesis
Pyruvate dehydrogenase E1 component middle
Could be important to modulate the pK values of the two catalytic cysteine residues
Phosphoribosylformylglycinamidine synthase linker
Cucumopine synthase C-terminal helical bundle
Pyrroline-5-carboxylate reductase dimerisation
Glucose-methanol-choline oxidoreductase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Translation elongation factor P/YeiP central
Schiff-base intermediate with D-ribose 5-phosphate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Phosphoadenosine phosphosulphate reductase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Putative L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
Anthranilate synthase component I N-terminal
Tat pathway signal sequence domain protein
Polymerase/histidinol phosphatase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Transition state stabilizer; via amide nitrogen
Small ribosomal subunit protein uS4 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Threonine/serine exporter-like N-terminal
Right handed beta helix domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Peptidoglycan recognition protein family
2,4-diaminopentanoate dehydrogenase C-terminal
Schiff-base intermediate with substrate; via topaquinone
Reversibly protonated during proton transport
Carbamoyl-phosphate synthase small subunit N-terminal
Phosphomannose isomerase type I catalytic
Cytochrome bc1 complex cytochrome c subunit
Styrene monooxygenase StyA putative substrate binding
NADH-rubredoxin oxidoreductase C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Transcription regulator AsnC/Lrp ligand binding
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glycosyl hydrolase-like 10 domain-containing protein
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Peptide methionine sulphoxide reductase MsrA
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Squalene cyclase C-terminal domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Ionotropic glutamate receptor C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Putative Flp pilus-assembly TadG-like N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Transposase IS116/IS110/IS902 C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL15/eL18
Cytochrome b561 bacterial/Ni-hydrogenase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Beta-lactamase class A catalytic domain-containing protein
2-oxoacid dehydrogenase acyltransferase catalytic
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Subtilisin inhibitor domain-containing protein
Heme-copper oxidase subunit III family profile
NADH:ubiquinone oxidoreductase 30kDa subunit
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Microcin J25-processing protein McjB C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Nucleophile; cysteine thiosulfonate intermediate
Putative oxidoreductase/dehydrogenase Rossmann-like
Involved in ionization of N3 of dUMP, leading to its activation
Shikimate dehydrogenase substrate binding N-terminal
Nuclear transport factor 2 family protein