DNA mismatch repair proteins mutS family
Pseudouridine synthase I TruA alpha/beta
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Polysaccharide biosynthesis protein CapD-like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Gliding motility-associated C-terminal domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Electron transfer via tryptophanyl radical
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL2 C-terminal
Tryptophan synthase beta chain-like PALP
Pyridine nucleotide-disulphide oxidoreductase dimerisation
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
TonB-dependent receptor-like beta-barrel
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Major facilitator superfamily (MFS) profile
Glycosyltransferase subfamily 4-like N-terminal
Putative auto-transporter adhesin head GIN
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NIF system FeS cluster assembly NifU N-terminal
Saccharopine dehydrogenase-like C-terminal
Outer membrane protein assembly factor BamD
NAD(P) transhydrogenase alpha subunit C-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase S9 prolyl oligopeptidase catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Alanyl-transfer RNA synthetases family profile
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Required for zinc-mediated homotetramerization and catalytic activity
Type III restriction enzyme C-terminal endonuclease
Signal transduction histidine kinase dimerisation/phosphoacceptor
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribosomal RNA adenine methylase transferase N-terminal
Chromosomal replication initiator protein DnaA
O-(5'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
N-end rule aminoacyl transferase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Nitrite/Sulfite reductase ferredoxin-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Bacterial type II secretion system protein E
Cytochrome c-type biogenesis protein CcmF C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glycoside hydrolase family 5 domain-containing protein
Outer membrane protein beta-barrel domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Heme-copper oxidase subunit III family profile
Carboxypeptidase regulatory-like domain-containing protein
ABC-type uncharacterised transport system
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Trypsin-like peptidase domain-containing protein
Prokaryotic-type class I peptide chain release factors
RND efflux pump membrane fusion protein barrel-sandwich
UDP-glucose/GDP-mannose dehydrogenase C-terminal
PhoD-like phosphatase metallophosphatase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
TtsA-like Glycoside hydrolase family 108
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Plays an important role in substrate specificity
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Restriction system protein Mrr-like N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
O-(3'-phospho-DNA)-tyrosine intermediate
Type II secretion system protein GspI C-terminal
PHA accumulation regulator DNA-binding N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
S-adenosylmethionine-dependent methyltransferase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Interaction with polymerase core subunit RpoC
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphoribosylformylglycinamidine synthase linker
Shikimate dehydrogenase substrate binding N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
DNA-directed DNA polymerase family A palm
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)
NADH:ubiquinone oxidoreductase 30kDa subunit
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Peptide methionine sulphoxide reductase MsrA
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein uL6 alpha-beta
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glyoxalase/fosfomycin resistance/dioxygenase
Could be important to modulate the pK values of the two catalytic cysteine residues
Membrane insertase YidC/Oxa/ALB C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Thioredoxin-like fold domain-containing protein
Essential for prephenate dehydratase activity
Organic solvent tolerance-like N-terminal
Small ribosomal subunit protein uS4 N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Pyruvate phosphate dikinase AMP/ATP-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Translation elongation factor P/YeiP central
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Polymerase/histidinol phosphatase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Peptidase S8/S53 domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Reversibly protonated during proton transport
Survival protein SurE-like phosphatase/nucleotidase
Large ribosomal subunit protein uL15/eL18
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Cobaltochelatase subunit CobS N-terminal
SGNH hydrolase-type esterase domain-containing protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
C-type lysozyme inhibitor domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Beta-lactamase hydrolase-like protein phosphatase-like
Outer membrane lipoprotein-sorting protein
SUF system FeS cluster assembly SufBD N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
DNA replication/recombination mediator RecO N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Gamma-glutamylcyclotransferase AIG2-like
CagE TrbE VirB component of type IV transporter system central
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Prepilin type IV endopeptidase peptidase
Signal recognition particle SRP54 helical bundle
Thymidylate synthase/dCMP hydroxymethylase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Methionyl-tRNA synthetase anticodon-binding
Carbamoyl-phosphate synthase small subunit N-terminal
Type I restriction modification DNA specificity
Ribose-phosphate pyrophosphokinase N-terminal
Beta-lactamase-related domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
Polysaccharide biosynthesis protein C-terminal
Proton acceptor; for glutaminase activity
LPXTG cell wall anchor domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
RNA binding; important for wobble base 34 recognition
Biopterin-dependent aromatic amino acid hydroxylase family profile
Alginate export domain-containing protein
Lysozyme inhibitor LprI N-terminal domain-containing protein
Penicillin-binding protein transpeptidase
Outer membrane protein assembly factor BamA
tRNA pseudouridylate synthase B C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Alpha-D-phosphohexomutase alpha/beta/alpha
Glucose-methanol-choline oxidoreductase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
ATP-grasp fold succinyl-CoA synthetase-type
Histidine phosphotransferase ChpT C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Anthranilate synthase component I N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Tetrahydrodipicolinate-N-succinyltransferase chain A