Formamidopyrimidine-DNA glycosylase catalytic
Cell envelope-related transcriptional attenuator
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Transposase IS116/IS110/IS902 C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
RNA polymerase sigma factor 70 region 4 type 2
Probable subtilase-type protease inhibitor
Haemophore haem-binding domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Histidine-specific methyltransferase SAM-dependent
PhoD-like phosphatase metallophosphatase
Glucosamine/galactosamine-6-phosphate isomerase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
DNA replication/recombination mediator RecO N-terminal
Threonine/serine exporter-like N-terminal
Major facilitator superfamily (MFS) profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Prokaryotic-type class I peptide chain release factors
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA primase/polymerase bifunctional N-terminal
AB hydrolase-1 domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
Phosphoribosylformylglycinamidine synthase linker
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Penicillin-binding protein transpeptidase
Molybdopterin cofactor biosynthesis C (MoaC)
Aminoacyl-transfer RNA synthetases class-II family profile
CobB/CobQ-like glutamine amidotransferase
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Polymerase/histidinol phosphatase N-terminal
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Peptidase S9 prolyl oligopeptidase catalytic
Peptidase M1 membrane alanine aminopeptidase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Pyruvate dehydrogenase E1 component middle
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Involved in allosteric activation by GTP
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Heme-copper oxidase subunit III family profile
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Solute-binding protein family 3/N-terminal
4'-phosphopantetheinyl transferase N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
NADH:flavin oxidoreductase/NADH oxidase N-terminal
6-phosphogluconate dehydrogenase C-terminal
TIGR04222 domain-containing membrane protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Essential for prephenate dehydratase activity
Transposase IS204/IS1001/IS1096/IS1165 DDE
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Subtilisin inhibitor domain-containing protein
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Glucose-methanol-choline oxidoreductase N-terminal
Transglycosylase SLT domain-containing protein
Lactate utilization protein B C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyridoxamine 5'-phosphate oxidase putative
ABC-type glycine betaine transport system substrate-binding
Ribose-phosphate pyrophosphokinase N-terminal
Increases nucleophilicity of active site Cys
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glycosyltransferase subfamily 4-like N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Phosphatidic acid phosphatase type 2/haloperoxidase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ionotropic glutamate receptor C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Sporulation transcription regulator WhiA N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Shikimate dehydrogenase substrate binding N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Adaptive response protein AidB N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Glycine cleavage T-protein C-terminal barrel
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyl transferase family 3 N-terminal
Integral membrane protein YccS N-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Bulb-type lectin domain-containing protein
DNA-directed DNA polymerase family A palm
NIF system FeS cluster assembly NifU N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Transcription regulator AsnC/Lrp ligand binding
Alpha-L-arabinofuranosidase B arabinose-binding
Ricin B lectin domain-containing protein
Type I restriction modification DNA specificity
Putative Flp pilus-assembly TadG-like N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL6 alpha-beta
Proteinase inhibitor I42 chagasin domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Release factor glutamine methyltransferase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
BAAT/Acyl-CoA thioester hydrolase C-terminal
Peptide methionine sulphoxide reductase MsrA
NADH:ubiquinone oxidoreductase 30kDa subunit
Removed in mature form; by autocatalysis
Cysteine sulfenic acid (-SOH) intermediate
Proton acceptor; for glutaminase activity
Large ribosomal subunit protein uL15/eL18
Prepilin type IV endopeptidase peptidase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Gly-cisPro motif, important for rejection of L-amino acids
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Important for beta-aspartyl-AMP intermediate formation
Tat pathway signal sequence domain protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Reversibly protonated during proton transport
Positions MEP for the nucleophilic attack
Chitosanase (Glycosyl hydrolase group 75)
Cytochrome C biogenesis protein transmembrane
Tryptophan synthase beta chain-like PALP
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Schiff-base intermediate with substrate; via topaquinone
Cytochrome b/b6 N-terminal region profile
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Translation elongation factor P/YeiP central
DnaJ homologue subfamily C member 28 conserved
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
PknH-like extracellular domain-containing protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Anthranilate synthase component I N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Phosphomannose isomerase type I catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Small ribosomal subunit protein uS4 N-terminal
Plays an important role in substrate specificity
TrbL/VirB6 plasmid conjugal transfer protein
Na+/H+ antiporter MnhB subunit-related protein
Large ribosomal subunit protein uL2 C-terminal
Thiopeptide-type bacteriocin biosynthesis
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Damage-control phosphatase ARMT1-like metal-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Nuclear transport factor 2 family protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
N-acetylneuraminic acid synthase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Gram-positive cocci surface proteins LPxTG
Bacterial type II secretion system protein E
Putative adhesin domain-containing protein
Phosphotransferase system enzyme I N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Membrane insertase YidC/Oxa/ALB C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Probable transposase IS891/IS1136/IS1341
Glycosyl hydrolase-like 10 domain-containing protein
Putative glycogen debranching enzyme N-terminal
Interaction with polymerase core subunit RpoC
Survival protein SurE-like phosphatase/nucleotidase
Cytochrome oxidase subunit II copper A binding
Heavy metal-binding domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
ABC transporter substrate-binding protein PnrA-like
O-(5'-phospho-DNA)-tyrosine intermediate
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Glycerophosphoryl diester phosphodiesterase family protein
MmyB-like transcription regulator ligand binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
L-seryl-tRNA selenium transferase N-terminal
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Diacylglycerol glucosyltransferase N-terminal
Putative amidase domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Phosphocysteine intermediate; for EIIB activity
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Ribosomal RNA adenine methylase transferase N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Diiron non-heme beta-hydroxylase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
Lon proteolytic domain-containing protein
Peptidase C39-like domain-containing protein
vWA-MoxR associated protein middle region 0
LPXTG cell wall anchor domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
CRISPR-associated protein Cas6 C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
RlpA-like protein double-psi beta-barrel
RlpA-like protein double-psi beta-barrel domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NIF system FeS cluster assembly NifU C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Heat-inducible transcription repressor HrcA C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Fibronectin type-III domain-containing protein
N,N-dimethylformamidase beta subunit-like C-terminal
Resolvase/invertase-type recombinase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Capsule synthesis protein CapA domain-containing protein
Cation-transporting P-type ATPase N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glycerophosphoryl diester phosphodiesterase membrane
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Microcin J25-processing protein McjB C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Acyltransferase MbtK/IucB-like conserved
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)
Cation-transporting P-type ATPase C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Bacterial Ig-like domain-containing protein
Schiff-base intermediate with D-ribose 5-phosphate
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Tetracyclin repressor-like C-terminal group 31
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Exonuclease VII large subunit C-terminal
Cytochrome bc1 complex cytochrome c subunit
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Erythromycin biosynthesis protein CIII-like central
Methionyl-tRNA synthetase anticodon-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
L,D-transpeptidase catalytic domain-containing protein
Alanyl-transfer RNA synthetases family profile
Squalene cyclase C-terminal domain-containing protein
Styrene monooxygenase StyA putative substrate binding
Electron transfer via tryptophanyl radical
Pseudouridine synthase I TruA alpha/beta
CD-NTase-associated protein 12/Pycsar effector protein TIR
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Sodium/calcium exchanger membrane region
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Type VII secretion system protein EssD-like
Putative oxidoreductase/dehydrogenase Rossmann-like