Major facilitator superfamily (MFS) profile
Phosphocysteine intermediate; for EIIB activity
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Polysaccharide biosynthesis protein CapD-like
Bulb-type lectin domain-containing protein
Schiff-base intermediate with substrate; via pyruvic acid
Polysaccharide biosynthesis protein C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Cell envelope-related transcriptional attenuator
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
D-glutamate N-acetyltransferase-like C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Copper amine oxidase-like N-terminal domain-containing protein
Alanyl-transfer RNA synthetases family profile
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cytochrome b/b6 N-terminal region profile
RNA polymerase sigma factor 70 region 4 type 2
Heme-copper oxidase subunit III family profile
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Bacterial transcription activator effector binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Could play a key role in the communication between the regulatory and the substrate sites
Polysaccharide chain length determinant N-terminal
DNA-directed DNA polymerase family A palm
Aminoacyl-transfer RNA synthetases class-II family profile
ABC-type glycine betaine transport system substrate-binding
Penicillin-binding protein transpeptidase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
ABC transporter substrate-binding protein PnrA-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Solute-binding protein family 3/N-terminal
Polymerase/histidinol phosphatase N-terminal
Major facilitator superfamily associated
Large ribosomal subunit protein uL2 C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Ribonucleotide reductase large subunit C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
CobB/CobQ-like glutamine amidotransferase
6-phosphogluconate dehydrogenase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Translation elongation factor P/YeiP central
Cation-transporting P-type ATPase N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Lysidine-tRNA(Ile) synthetase C-terminal
Positions MEP for the nucleophilic attack
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Tail specific protease domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Microcin J25-processing protein McjB C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Signal recognition particle SRP54 helical bundle
Carbamoyl-phosphate synthetase large subunit-like ATP-binding
Carbamoyl-phosphate synthetase large subunit-like ATP-binding domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Bacterial type II secretion system protein E
ABC transporter substrate-binding protein
Helix-hairpin-helix DNA-binding motif class 1
Glycosyltransferase subfamily 4-like N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Gram-positive cocci surface proteins LPxTG
Tryptophan synthase beta chain-like PALP
Prepilin type IV endopeptidase peptidase
Important for beta-aspartyl-AMP intermediate formation
Mannose-6-phosphate isomerase type II C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Formamidopyrimidine-DNA glycosylase catalytic
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Inhibitor of growth protein N-terminal histone-binding domain-containing protein
Cell wall-active antibiotics response LiaF-like C-terminal
Schiff-base intermediate with acetaldehyde
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Exonuclease VII large subunit C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycoside hydrolase family 85 domain-containing protein
Glycosyl transferase family 3 N-terminal
DNA mismatch repair proteins mutS family
Butirosin biosynthesis protein H N-terminal
Glycoside hydrolase family 42 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Inosine/uridine-preferring nucleoside hydrolase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Schiff-base intermediate with D-ribose 5-phosphate
Ferrous iron transport protein B C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Phosphomannose isomerase type I catalytic
Pyrimidine nucleoside phosphorylase C-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Glycosyltransferase family 28 N-terminal
Signal transduction histidine kinase internal region
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
SsuA/THI5-like domain-containing protein
Glycoside hydrolase family 31 N-terminal
Resolvase/invertase-type recombinase catalytic
N6 adenine-specific DNA methyltransferase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Septum formation inhibitor MinC C-terminal
Sporulation transcription regulator WhiA N-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
RNA binding; important for wobble base 34 recognition
Plays an important role in substrate specificity
Na+-translocating membrane potential-generating system MpsC
Pseudouridine synthase I TruA alpha/beta
DnaJ homologue subfamily C member 28 conserved
Helix-turn-helix conjugative transposon-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glycosyl hydrolase family 30 beta sandwich
NIF system FeS cluster assembly NifU C-terminal
Sugar ABC transporter substrate-binding protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Putative aromatic acid exporter C-terminal
Threonine/serine exporter-like N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Dinitrogenase iron-molybdenum cofactor biosynthesis
Ribose-phosphate pyrophosphokinase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Sporulation stage IV protein A C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RND efflux pump membrane fusion protein barrel-sandwich
Bacterial bifunctional deaminase-reductase C-terminal
Alpha galactosidase C-terminal beta sandwich
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
HicB-like antitoxin of toxin-antitoxin system
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Aminoacyl-tRNA synthetase class I anticodon-binding
Protein-PII uridylyltransferase N-terminal
Transcription regulator AsnC/Lrp ligand binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Beta-1,3-glucanase N-terminal domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Peptidase M14 carboxypeptidase A domain-containing protein
DNA-3-methyladenine glycosylase AlkA N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Small ribosomal subunit protein uS4 N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
Cyclic nucleotide phosphodiesterase C-terminal
Dipicolinate synthase subunit A N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
ssDNA thymidine ADP-ribosyltransferase DarT
Large ribosomal subunit protein uL30-like ferredoxin-like fold
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Increases nucleophilicity of active site Cys
Meso-diaminopimelate D-dehydrogenase C-terminal
Flagellar Assembly Protein A N-terminal region
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Peptide methionine sulphoxide reductase MsrA
Flagellar motor switch protein FliN-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Sporulation stage II protein D amidase enhancer LytB N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Involved in allosteric activation by GTP
Large ribosomal subunit protein bL9 C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Type I restriction modification DNA specificity
Phosphoribosylformylglycinamidine synthase linker
Large ribosomal subunit protein bL12 oligomerization
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Thiamin pyrophosphokinase thiamin-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Transposase IS116/IS110/IS902 C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Proton acceptor; for glutaminase activity
O-(5'-phospho-DNA)-tyrosine intermediate
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Zinc ABC transporter substrate-binding protein
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Pyridoxamine 5'-phosphate oxidase putative
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Cytochrome b561 bacterial/Ni-hydrogenase
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
RNA 2-O ribose methyltransferase substrate binding
Methyltransferase domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
DNA replication/recombination mediator RecO N-terminal
Phosphotransferase system enzyme I N-terminal
Transcriptional regulator SgrR N-terminal HTH
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Molybdopterin cofactor biosynthesis C (MoaC)
Transcriptional regulator TetR C-terminal Firmicutes type
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Membrane insertase YidC/Oxa/ALB C-terminal
Interaction with polymerase core subunit RpoC
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Anthranilate synthase component I N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Schiff-base intermediate with dihydroxyacetone-P
Cytochrome C biogenesis protein transmembrane
Saccharopine dehydrogenase-like C-terminal
Ionotropic glutamate receptor C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Sodium/calcium exchanger membrane region
Glycine cleavage T-protein C-terminal barrel
Could be important to modulate the pK values of the two catalytic cysteine residues
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Spore germination GerAC-like C-terminal domain-containing protein
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Release factor glutamine methyltransferase N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
CD-NTase-associated protein 12/Pycsar effector protein TIR
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Large ribosomal subunit protein uL15/eL18
Nitrogenase molybdenum-iron protein beta chain N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
NIF system FeS cluster assembly NifU N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Important for interaction with partner proteins
Essential for prephenate dehydratase activity
Reversibly protonated during proton transport
General stress protein FMN-binding split barrel
S-adenosylmethionine-dependent methyltransferase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glutathionylspermidine synthase pre-ATP-grasp-like
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Beta-lactamase-related domain-containing protein