DNA replication/recombination mediator RecO N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
peptide-methionine (R)-S-oxide reductase
Major facilitator superfamily (MFS) profile
YbaK/aminoacyl-tRNA synthetase-associated
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Solute-binding protein family 3/N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
N-end rule aminoacyl transferase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Cob(I)alamin adenosyltransferase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Gly-cisPro motif, important for rejection of L-amino acids
Proline utilization A proline dehydrogenase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Surface antigen domain-containing protein
Tryptophan synthase beta chain-like PALP
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Cytochrome b561 bacterial/Ni-hydrogenase
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Heme-copper oxidase subunit III family profile
Signal transduction histidine kinase internal region
Release factor glutamine methyltransferase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glucose-methanol-choline oxidoreductase N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Endoribonuclease L-PSP/chorismate mutase-like
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycosyltransferase subfamily 4-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Mandelate racemase/muconate lactonizing enzyme C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Bacteriophage N4 adsorption protein A C-terminal
Glycine cleavage T-protein C-terminal barrel
RNA binding; important for wobble base 34 recognition
Putative oxidoreductase/dehydrogenase Rossmann-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
TRAP C4-dicarboxylate transport system permease DctM subunit
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
TonB-dependent receptor-like beta-barrel
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Transcription elongation factor GreA/GreB N-terminal
Cobaltochelatase subunit CobS N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Glucan biosynthesis periplasmic MdoG C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Survival protein SurE-like phosphatase/nucleotidase
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Thymidylate synthase/dCMP hydroxymethylase
Gamma-glutamylcyclotransferase AIG2-like
Small ribosomal subunit protein uS4 N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Penicillin-binding protein transpeptidase
Phosphatidic acid phosphatase type 2/haloperoxidase
Flavocytochrome c sulphide dehydrogenase flavin-binding
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
PHA accumulation regulator DNA-binding N-terminal
Exonuclease VII large subunit C-terminal
Outer membrane protein assembly factor BamD
Sodium/calcium exchanger membrane region
Guanylate kinase/L-type calcium channel beta subunit
Alpha-D-phosphohexomutase alpha/beta/alpha
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Membrane fusion protein biotin-lipoyl like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Essential for prephenate dehydratase activity
Ionotropic glutamate receptor C-terminal
CNP1-like uncharacterized domain-containing protein
Plays an important role in substrate specificity
Flagellar motor switch protein FliN-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Type III secretion system flagellar brake protein YcgR PilZN
Large ribosomal subunit protein uL15/eL18
Aspartate/homoserine dehydrogenase NAD-binding
DNA polymerase III subunit delta C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
UDP N-acetylglucosamine O-acyltransferase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Glucose-methanol-choline oxidoreductase C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Pyruvate dehydrogenase E1 component middle
NADH:ubiquinone oxidoreductase 30kDa subunit
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL2 C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
S-adenosyl-L-homocysteine hydrolase NAD binding
Bacterial type II secretion system protein E
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Pyruvate phosphate dikinase AMP/ATP-binding
Molybdopterin cofactor biosynthesis C (MoaC)
Cation-transporting P-type ATPase N-terminal
Interaction with polymerase core subunit RpoC
L-seryl-tRNA selenium transferase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Schiff-base intermediate with substrate; via pyruvic acid
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Putative Flp pilus-assembly TadG-like N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Flagellar hook-length control protein-like C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Required for dimer formation and molybdate binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Reversibly protonated during proton transport
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Important for interaction with partner proteins
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
ATP synthase F1 complex delta/epsilon subunit N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Proton acceptor; for glutaminase activity
RNA 2-O ribose methyltransferase substrate binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Anthranilate synthase component I N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Lytic transglycosylase superhelical linker
Saccharopine dehydrogenase-like C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Virulence factor membrane-bound polymerase C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Pseudouridine synthase I TruA alpha/beta
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
CobB/CobQ-like glutamine amidotransferase
Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Polypeptide-transport-associated ShlB-type
Putative regulatory protein FmdB Zinc ribbon
NADH:ubiquinone oxidoreductase chain 4 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA mismatch repair proteins mutS family
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Polymerase/histidinol phosphatase N-terminal
Chromosomal replication initiator DnaA C-terminal
6-phosphogluconate dehydrogenase C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Cysteine sulfenic acid (-SOH) intermediate
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Alanyl-transfer RNA synthetases family profile
Chalcone isomerase domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
DNA-directed DNA polymerase family A palm
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Integral membrane protein YccS N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Transposase IS204/IS1001/IS1096/IS1165 DDE
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Adaptive response protein AidB N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Hypersensitivity response secretion-like HrpJ
Type III secretion system effector delivery regulator TyeA
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Histidine-specific methyltransferase SAM-dependent
Electron transfer via tryptophanyl radical
Helix-hairpin-helix DNA-binding motif class 1
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Prokaryotic-type class I peptide chain release factors
Tetrahydrodipicolinate-N-succinyltransferase chain A
Phosphotransferase system enzyme I N-terminal
NIF system FeS cluster assembly NifU N-terminal
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Translation elongation factor P/YeiP central
Moybdenum cofactor oxidoreductase dimerisation
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Carbamoyl-phosphate synthase small subunit N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Sodium symporter small subunit predicted
Plays an important role in discriminating NADH against NADPH
ABC transporter substrate-binding protein PnrA-like
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Glycosyl transferase family 3 N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
PilX/PilW C-terminal domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Prepilin type IV endopeptidase peptidase
Alpha-glycerophosphate oxidase C-terminal
Chromosomal replication initiator protein DnaA
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Positions MEP for the nucleophilic attack
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Gamma-butyrobetaine hydroxylase-like N-terminal