S-adenosylmethionine-dependent methyltransferase
Resolvase/invertase-type recombinase catalytic
Transcriptional coactivator p15 (PC4) C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphatidic acid phosphatase type 2/haloperoxidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Involved in allosteric activation by GTP
NIF system FeS cluster assembly NifU N-terminal
Translation elongation factor P/YeiP central
Phosphocysteine intermediate; for EIIB activity
Large ribosomal subunit protein uL15/eL18
YbaK/aminoacyl-tRNA synthetase-associated
6-phosphogluconate dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Tryptophan synthase beta chain-like PALP
Membrane insertase YidC/Oxa/ALB C-terminal
ABC transporter substrate-binding protein PnrA-like
Gfo/Idh/MocA-like oxidoreductase N-terminal
Important for interaction with partner proteins
Interaction with polymerase core subunit RpoC
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Putative aromatic acid exporter C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Carbamoyl-phosphate synthase small subunit N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Gly-cisPro motif, important for rejection of L-amino acids
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Gram-positive cocci surface proteins LPxTG
O-(3'-phospho-DNA)-tyrosine intermediate
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
ATP synthase F1 complex delta/epsilon subunit N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycosyltransferase subfamily 4-like N-terminal
Reversibly protonated during proton transport
Cysteine sulfenic acid (-SOH) intermediate
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Small ribosomal subunit protein uS4 N-terminal
Bacterial type II secretion system protein E
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Cell envelope-related transcriptional attenuator
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Alpha-glycerophosphate oxidase C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Phosphotransferase system enzyme I N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Peptidase M1 membrane alanine aminopeptidase
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Type I restriction modification DNA specificity
Aminoacyl-transfer RNA synthetases class-II family profile
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Terminase large subunit-like endonuclease
Penicillin-binding protein transpeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Schiff-base intermediate with acetaldehyde
DNA mismatch repair proteins mutS family
DNA/RNA non-specific endonuclease domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Prokaryotic-type class I peptide chain release factors
Glucosamine/galactosamine-6-phosphate isomerase
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alanyl-transfer RNA synthetases family profile
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
RNA binding; important for wobble base 34 recognition
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
HicB-like antitoxin of toxin-antitoxin system
Exonuclease VII large subunit C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Peptidase M26 C-terminal domain-containing protein
Gram-positive cocci surface proteins LPxTG domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Major facilitator superfamily (MFS) profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cell wall-active antibiotics response LiaF-like C-terminal
Pseudouridine synthase I TruA alpha/beta
RNA polymerase sigma factor 70 region 4 type 2
Tellurite resistance methyltransferase TehB-like
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptidase C39-like domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
LysM peptidoglycan-binding domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Regulator of chromosome segregation-like C-terminal
Sporulation transcription regulator WhiA N-terminal
Threonine/serine exporter-like N-terminal
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 3
Shikimate dehydrogenase substrate binding N-terminal
Phosphoribosylformylglycinamidine synthase linker
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Dihydrodipicolinate reductase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Polysaccharide biosynthesis protein C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Thiamin pyrophosphokinase thiamin-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Cytochrome C biogenesis protein transmembrane
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Polysaccharide chain length determinant N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Conserved virulence factor B-like winged helix
Chromosomal replication initiator DnaA C-terminal
Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
BAAT/Acyl-CoA thioester hydrolase C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
DNA-directed DNA polymerase family A palm
Cation-transporting P-type ATPase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Plays an important role in substrate specificity