Major facilitator superfamily (MFS) profile
Peptidase S9 prolyl oligopeptidase catalytic
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Neutral/alkaline non-lysosomal ceramidase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Terminase large subunit-like endonuclease
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Penicillin-binding protein transpeptidase
Polymerase/histidinol phosphatase N-terminal
TonB-dependent receptor-like beta-barrel
Outer membrane protein assembly factor BamD
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein bL25 L25
Excalibur calcium-binding domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Resolvase/invertase-type recombinase catalytic
Solute-binding protein family 3/N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Chromosomal replication initiator protein DnaA
Ribosomal RNA adenine methylase transferase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cytochrome b561 bacterial/Ni-hydrogenase
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
NADH:flavin oxidoreductase/NADH oxidase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
Acyltransferase MbtK/IucB-like conserved
Survival protein SurE-like phosphatase/nucleotidase
Alpha-D-phosphohexomutase alpha/beta/alpha
Electron transfer via tryptophanyl radical
RND efflux pump membrane fusion protein barrel-sandwich
Outer membrane protein assembly factor BamA
Outer membrane assembly lipoprotein YfiO
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Pseudouridine synthase I TruA alpha/beta
Membrane insertase YidC/Oxa/ALB C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Tryptophan synthase beta chain-like PALP
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Pyruvate phosphate dikinase AMP/ATP-binding
Small ribosomal subunit protein uS4 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
BspA family leucine-rich repeat surface protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Organic solvent tolerance-like N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
NIF system FeS cluster assembly NifU C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Integral membrane protein YccS N-terminal
RNA 2-O ribose methyltransferase substrate binding
Prokaryotic-type class I peptide chain release factors
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Prepilin type IV endopeptidase peptidase
DNA replication/recombination mediator RecO N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Thiol:disulfide interchange protein DsbD N-terminal
Alpha-glycerophosphate oxidase C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Erythronate-4-phosphate dehydrogenase dimerisation
Heme-copper oxidase subunit III family profile
Outer-membrane lipoprotein carrier protein
Virulence factor membrane-bound polymerase C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Bacterial type II secretion system protein E
Membrane fusion protein biotin-lipoyl like
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Anthranilate synthase component I N-terminal
DNA mismatch repair proteins mutS family
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
N-end rule aminoacyl transferase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Peptidase M17 leucyl aminopeptidase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Bacterial OB-fold domain-containing protein
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Important for substrate binding and specificity
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Tellurite resistance methyltransferase TehB-like
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Molybdenum ABC transporter substrate-binding protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Reversibly protonated during proton transport
Glucose-methanol-choline oxidoreductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Disulphide bond isomerase DsbC/G N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycine zipper 2TM domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Pyruvate dehydrogenase E1 component middle
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Type I restriction modification DNA specificity
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Ribose-phosphate pyrophosphokinase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Quercetin 2,3-dioxygenase C-terminal cupin
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Regulator of nucleoside diphosphate kinase N-terminal
Polysaccharide chain length determinant N-terminal
Phosphoethanolamine transferase N-terminal
Carbapenem-associated resistance protein
Meso-diaminopimelate D-dehydrogenase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Abortive infection protein-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glutathionylspermidine synthase pre-ATP-grasp-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Could be important to modulate the pK values of the two catalytic cysteine residues
Restriction endonuclease type I HsdR N-terminal
Integrase lambda-type N-terminal DNA-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Chromosomal replication initiator DnaA C-terminal
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
O-(phosphoribosyl dephospho-coenzyme A)serine
NAD(P) transhydrogenase alpha subunit C-terminal
Involved in tetramerization or stability of the tetramer
DNA-directed DNA polymerase family A palm
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Carbamoyl-phosphate synthase small subunit N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Bacterial bifunctional deaminase-reductase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Choloylglycine hydrolase/NAAA C-terminal
Glycosyl transferase family 3 N-terminal
Transcription regulator AsnC/Lrp ligand binding
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Peptide methionine sulphoxide reductase MsrA
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Translation elongation factor P/YeiP central
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Gly-cisPro motif, important for rejection of L-amino acids
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Nicotinate phosphoribosyltransferase N-terminal
Lipopolysaccharide export system protein LptA
YbaK/aminoacyl-tRNA synthetase-associated
Release factor glutamine methyltransferase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
PhoD-like phosphatase metallophosphatase
Large ribosomal subunit protein uL15/eL18
RNA binding; important for wobble base 34 recognition
Type II secretion system protein GspI C-terminal
Superoxide dismutase copper/zinc binding
Methylguanine DNA methyltransferase ribonuclease-like
Aminoacyl-tRNA synthetase class I anticodon-binding
Glyoxalase/fosfomycin resistance/dioxygenase
Positions MEP for the nucleophilic attack
Malonate/sodium symporter MadM subunit N-terminal
Shikimate dehydrogenase substrate binding N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Type II secretion system protein GspG C-terminal
Essential for prephenate dehydratase activity
Pyrroline-5-carboxylate reductase dimerisation
Tetrahydrodipicolinate-N-succinyltransferase chain A
Plays an important role in substrate specificity
Transcription factor NikR nickel binding C-terminal
Important for autoinhibition of adenylyltransferase activity
Glycosyltransferase subfamily 4-like N-terminal
Phosphodiester glycosidase domain-containing protein
CagE TrbE VirB component of type IV transporter system central
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
NIF system FeS cluster assembly NifU N-terminal
Proton acceptor; for glutaminase activity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
N6 adenine-specific DNA methyltransferase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
RlpA-like protein double-psi beta-barrel
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Adaptive response protein AidB N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Large ribosomal subunit protein uL2 C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Type 2A encapsulin shell protein SrpI-like
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Schiff-base intermediate with substrate; via pyruvic acid
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Type IV secretion system coupling protein TraD DNA-binding
Beta-lactamase hydrolase-like protein phosphatase-like
TRAP C4-dicarboxylate transport system permease DctM subunit
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for interaction with partner proteins
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
RNA 3'-terminal phosphate cyclase insert
ATP synthase F1 complex delta/epsilon subunit N-terminal