Penicillin-binding protein transpeptidase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
RNA polymerase sigma factor 70 region 4 type 2
DNA polymerase III subunit delta C-terminal
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aminoacyl-transfer RNA synthetases class-II family profile
TRAP C4-dicarboxylate transport system permease DctM subunit
FAD-dependent oxidoreductase 2 FAD binding
Type II secretion system protein GspI C-terminal
PEP-CTERM protein-sorting domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Tryptophan synthase beta chain-like PALP
Trimeric autotransporter adhesin YadA-like stalk domain-containing protein
Glycosyl transferase family 28 C-terminal
Outer membrane lipoprotein BamD-like domain-containing protein
Interaction with polymerase core subunit RpoC
Solute-binding protein family 3/N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Major facilitator superfamily (MFS) profile
Helix-hairpin-helix DNA-binding motif class 1
Polymerase/histidinol phosphatase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Molybdopterin cofactor biosynthesis C (MoaC)
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Inner membrane protein YgaP-like transmembrane
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
RND efflux pump membrane fusion protein barrel-sandwich
Alginate export domain-containing protein
L,D-transpeptidase catalytic domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Positions MEP for the nucleophilic attack
Gly-cisPro motif, important for rejection of L-amino acids
Outer membrane protein assembly factor BamA
Translation elongation factor P/YeiP central
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Alpha-glycerophosphate oxidase C-terminal
Putative regulatory protein FmdB Zinc ribbon
Cysteine sulfenic acid (-SOH) intermediate
Peptide methionine sulphoxide reductase MsrA
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Phosphatidic acid phosphatase type 2/haloperoxidase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Thymidylate synthase/dCMP hydroxymethylase
Survival protein SurE-like phosphatase/nucleotidase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
PrcB C-terminal domain-containing protein
YbaK/aminoacyl-tRNA synthetase-associated
Bacterial type II secretion system protein E
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Anthranilate synthase component I N-terminal
Prokaryotic-type class I peptide chain release factors
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Electron transfer via tryptophanyl radical
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
RNA binding; important for wobble base 34 recognition
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Type II secretion system protein GspC N-terminal
Phosphoadenosine phosphosulphate reductase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Outer membrane protein beta-barrel domain-containing protein
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
CASTOR/POLLUX/SYM8 ion channel conserved
Polysaccharide chain length determinant N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Acyl-CoA dehydrogenase C-terminal bacterial-type
Membrane insertase YidC/Oxa/ALB C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Aromatic hydrocarbon degradation protein
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Chromosomal replication initiator protein DnaA
RNA methyltransferase SpoU/TrmH type C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyltransferase subfamily 4-like N-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Small ribosomal subunit protein uS4 N-terminal
Flagellar hook-length control protein-like C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Haem-binding uptake Tiki superfamily ChaN
Proline utilization A proline dehydrogenase N-terminal
Flagellar assembly protein T N-terminal domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Signal recognition particle subunit FFH/SRP54 (Srp54)
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Cytochrome c-type biogenesis protein CcmF C-terminal
Ionotropic glutamate receptor C-terminal
RNA 2-O ribose methyltransferase substrate binding
N-end rule aminoacyl transferase C-terminal
Adaptive response protein AidB N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Antitoxin Xre/MbcA/ParS-like toxin-binding
Transposase IS204/IS1001/IS1096/IS1165 DDE
Chromosomal replication initiator DnaA C-terminal
Nucleophile; cysteine thiosulfonate intermediate
SUF system FeS cluster assembly SufBD N-terminal
Pseudouridine synthase I TruA alpha/beta
Beta-lactamase hydrolase-like protein phosphatase-like
Beta-lactamase hydrolase-like protein phosphatase-like domain-containing protein
UDP N-acetylglucosamine O-acyltransferase C-terminal
Glycoside hydrolase family 57 N-terminal
PQQ-dependent catabolism-associated beta-propeller protein
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Outer-membrane lipoprotein carrier protein
Cytochrome oxidase subunit II copper A binding
Sec translocon accessory complex subunit YajC
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Phenol hydroxylase C-terminal dimerisation
Aminoacyl-tRNA synthetase class I anticodon-binding
Large ribosomal subunit protein uL15/eL18
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein uL2 C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
NIF system FeS cluster assembly NifU C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Alanyl-transfer RNA synthetases family profile
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Release factor glutamine methyltransferase N-terminal
TonB-dependent receptor-like beta-barrel
DNA-directed RNA polymerase RpoA/D/Rpb3-type
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
SsuA/THI5-like domain-containing protein
DNA mismatch repair proteins mutS family
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Bacterial bifunctional deaminase-reductase C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Lipoprotein SmpA/OmlA domain-containing protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Lysidine-tRNA(Ile) synthetase C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Membrane fusion protein biotin-lipoyl like
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Heme-copper oxidase subunit III family profile
Rap1a immunity protein domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cytochrome b561 bacterial/Ni-hydrogenase
Required for zinc-mediated homotetramerization and catalytic activity
Could play a key role in the communication between the regulatory and the substrate sites
Sodium symporter small subunit predicted
ATP synthase F1 complex delta/epsilon subunit N-terminal
Flagella basal body P-ring formation protein FlgA
Type 4 fimbrial biogenesis protein PilX N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Urease accessory protein UreH-like transmembrane
Flagellar motor switch protein FliN-like C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Twin-arginine translocation pathway signal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Important for interaction with partner proteins
Essential for prephenate dehydratase activity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Putative ATP-dependent zinc protease domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL6 alpha-beta
N6 adenine-specific DNA methyltransferase N-terminal
Sugar fermentation stimulation protein C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
ABC-type glycine betaine transport system substrate-binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Transglycosylase SLT domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA-directed DNA polymerase family A palm
Outer membrane protein assembly factor BamB
Prepilin type IV endopeptidase peptidase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Polysaccharide biosynthesis protein CapD-like
Proton acceptor; for glutaminase activity
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Arginine decarboxylase C-terminal helical
Glycosyl transferase family 3 N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Plays an important role in substrate specificity
Exonuclease VII large subunit C-terminal
Amino acid ABC transporter substrate-binding protein
Poly-beta-hydroxybutyrate polymerase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Reversibly protonated during proton transport
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
S-adenosylmethionine-dependent methyltransferase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Solute-binding protein family 5 domain-containing protein
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
GlyGly-CTERM sorting domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)
Flagellar assembly protein FliH/Type III secretion system HrpE
Ribonucleotide reductase large subunit C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Signal transduction histidine kinase internal region
Resolvase/invertase-type recombinase catalytic
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycosyltransferase family 28 N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Cation-transporting P-type ATPase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Outer membrane protein assembly factor BamD
Glucosamine/galactosamine-6-phosphate isomerase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Terminase large subunit-like endonuclease
DNA replication/recombination mediator RecO N-terminal
Tetratricopeptide repeat-like domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
Disulphide bond isomerase DsbC/G N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
4'-phosphopantetheinyl transferase N-terminal
Type I restriction modification DNA specificity
Cytochrome oxidase subunit II transmembrane region profile
Cytochrome c-552/DMSO reductase-like haem-binding
Cytochrome c-552/DMSO reductase-like haem-binding domain-containing protein
Glucose-methanol-choline oxidoreductase C-terminal