Ribose-phosphate pyrophosphokinase N-terminal
Trypanosome variant surface glycoprotein B-type N-terminal
Trypanosoma glutamic acid/alanine-rich protein
Trypanosoma glutamic acid/alanine-rich protein domain-containing protein
Transcription factor TFIIIB component B"" Myb
Electron transfer via tryptophanyl radical
Calcineurin-like phosphoesterase domain-containing protein
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Retrotransposon hot spot protein N-terminal
Retrotransposon hot spot protein,C-terminal
Eukaryotic translation initiation factor 3 subunit C N-terminal
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Trypanosome variant surface glycoprotein A-type N-terminal
Dolichol phosphate-mannose biosynthesis regulatory protein
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
Beta-adaptin appendage C-terminal subdomain
RecQ mediated genome instability protein 1 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Peptidase S9 prolyl oligopeptidase catalytic
Trypanosome variant surface glycoprotein C-terminal
ER membrane protein complex subunit 1 C-terminal
Glycosyl transferase family 28 C-terminal
N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase
Calponin-homology (CH) domain-containing protein
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Ubiquitin-activating enzyme E1 C-terminal
Small ribosomal subunit protein uS4 N-terminal
Cation-transporting P-type ATPase N-terminal
Ancestral coatomer element 1 Sec16/Sec31
Anaphase-promoting complex subunit 4-like WD40
AP-4 complex subunit epsilon-1 C-terminal
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
Major facilitator superfamily (MFS) profile
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Serine/threonine specific protein phosphatases
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
RecQ mediated genome instability protein 1-like N-terminal helical
Exocyst complex component EXOC2/Sec5 N-terminal
Proteasome activator complex subunit 4 C-terminal
Pseudouridine synthase I TruA alpha/beta
CNNM transmembrane domain-containing protein
Homologous-pairing protein 2 winged helix
Enriched in surface-labeled proteome protein 11
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Ribosomal RNA adenine methylase transferase N-terminal
Enriched in surface-labeled proteome protein 9
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Trypanosome variant surface glycoprotein B-type N-terminal domain-containing protein
Nuclear condensin complex subunit 3 C-terminal
Large ribosomal subunit protein uL10-like insertion
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Rapamycin-insensitive companion of mTOR N-terminal
Rapamycin-insensitive companion of mTOR middle
Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NIF system FeS cluster assembly NifU N-terminal
V-type proton ATPase proteolipid subunit
Ribonuclease H2 subunit B wHTH domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
tRNA/rRNA methyltransferase SpoU type domain-containing protein
Vacuolar protein sorting-associated protein 54 C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Transcription factor CBF/NF-Y/archaeal histone
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL6 alpha-beta
Generative cell specific-1/HAP2 domain-containing protein
Calcium-activated potassium channel BK alpha subunit
ER membrane protein complex subunit 7 beta-sandwich
ER membrane protein complex subunit 7 beta-sandwich domain-containing protein
Prokaryotic-type class I peptide chain release factors
DNA mismatch repair proteins mutS family
Small ribosomal subunit protein uS15 N-terminal
Histone RNA hairpin-binding protein RNA-binding
Small ribosomal subunit protein uS5 C-terminal
Signal recognition particle SRP72 subunit RNA-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Phosphatidylserine amidated glycine; alternate
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Pentacotripeptide-repeat region of PRORP
GPI-GlcNAc transferase complex PIG-H component conserved
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Vacuolar protein 14 C-terminal Fig4-binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
NIF system FeS cluster assembly NifU C-terminal
Ribosomal RNA-processing protein 7 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Gamma-butyrobetaine hydroxylase-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Probable eukaryotic initiation factor 4A
U2A'/phosphoprotein 32 family A C-terminal
Exocyst complex component Sec3 C-terminal
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Minichromosome loss protein Mcl1 middle region
Leucine-rich repeat-containing protein 56 homolog
Reduced cell motility and reduced number of outer dynein arms. Localizes normally to the distal portion of the flagellum.
U3 small nucleolar RNA-associated protein 15 C-terminal
Clathrin/coatomer adaptor adaptin-like N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
DNA-directed RNA polymerase subunit 2 hybrid-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
NF-kappa-B-activating protein C-terminal
Dynein heavy chain hydrolytic ATP-binding dynein motor region
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Uncharacterized protein Tb927.8.680, mitochondrial
DNA-directed DNA polymerase family B multifunctional
37 X 14 AA tandem repeats of E-E-L-E-L-K-[VA]-A-E-N-E-K-L-A
Dynein heavy chain ATP-binding dynein motor region
DNA polymerase epsilon catalytic subunit A C-terminal
Alanyl-transfer RNA synthetases family profile
CCR4-Not complex component Not N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal domain-containing protein
Protein N-terminal glutamine amidohydrolase alpha beta roll
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
NAD-dependent protein deacetylase SIR2rp1
tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Small nuclear ribonucleoprotein Prp3 C-terminal
3-fold increase in catalytic activity towards substrates.
Important for Arg/Lys-specific substrate specificity
Increases autoprocessing resulting in the degradation of the enzyme.
Loss of autoprocessing and catalytic activity towards substrates.
Loss of autoprocessing. Loss of catalytic activity towards large protein substrates, no effect on catalytic activity towards short oligopeptide substrates, reduces affinity of the high affinity Ca(2+) binding site, shift optimum pH for activity towards basic pH; when associated with G-55.
Loss of autoprocessing. Loss of catalytic activity towards large protein substrates, no effect on catalytic activity towards short oligopeptide substrates, reduces affinity of the high affinity Ca(2+) binding site, shifts optimum pH for activity towards basic pH; when associated with G-268.
Reduced autoprocessing and 50% loss of catalytic activity towards substrates.
Regulates substrate access to the active site
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glyceraldehyde-3-phosphate dehydrogenase
Inositol polyphosphate-related phosphatase
Peptide methionine sulphoxide reductase MsrA
Cation-transporting P-type ATPase C-terminal
Large ribosomal subunit protein mL46 N-terminal
Abscisic acid G-protein coupled receptor-like
SAM-dependent methyltransferase TRM5/TYW2-type
RNA polymerase subunit H/Rpb5 C-terminal
Spo11/DNA topoisomerase VI subunit A N-terminal
Cns1/TTC4 wheel domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Enriched in surface-labeled proteome protein 12
Peptidase M1 membrane alanine aminopeptidase
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
DNA recombination and repair protein Rad51-like C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Conserved oligomeric Golgi complex subunit 4
Programmed cell death protein 2 C-terminal
PhoD-like phosphatase metallophosphatase
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
Dynein regulatory complex protein 1 C-terminal
Dynein regulatory complex protein 1/2 N-terminal
Translocon-associated protein subunit beta
U3 small nucleolar RNA-associated protein 20 C-terminal
U3 small nucleolar RNA-associated protein 20 N-terminal
DNA polymerase alpha/delta/epsilon subunit B
Bifunctional helicase and thymine dioxygenase JBP2
Induces a slight reduction in DNA base J biosynthesis.
Cilia- and flagella-associated protein 61 N-terminal
Enriched in surface-labeled proteome protein 18
Nascent polypeptide-associated complex subunit alpha-like UBA
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
N-acetyltransferase ESCO acetyl-transferase
SAM-dependent methyltransferase Erg6/SMT-type
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 CAF1-binding
CCR4-NOT transcription complex subunit 1 TTP binding
CCR4-Not complex component Not1 C-terminal
Peptidase S54 rhomboid domain-containing protein
Pre-mRNA processing factor 4 (PRP4)-like
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Abolishes MKT1 binding. Abolishes positive regulation of protein expression.
Translocon-associated protein subunit alpha
Does not affect the interaction with H2F1 and GAP1/GRBC2.
Loss of RNA helicase activity. Loss of binding to gRNA. Impaired association with several mRNA editing complexes.
Loss of RNA helicase activity. Loss of interaction with gRNA, unedited mRNAs and edited mRNAs at block 1 or at 5' distal blocks. Loss of interaction with GAP1/GRBC2.
Loss of interaction with gRNA, unedited mRNAs, edited mRNAs at block 1 or at 5' distal blocks, and GAP1/GRBC2 but not with H2F1; when associated with A-1078.
Loss of interaction with gRNA, unedited mRNAs, edited mRNAs at block 1 or at 5' distal blocks, and GAP1/GRBC2 but not with H2F1; when associated with D-1086.
Moderate reduction in the interaction with GAP1/GRBC2. Interaction with H2F1 is normal.
Moderate reduction in the interaction with GAP1/GRBC2. Interaction with H2F1 is normal. Severe reduction in the interaction with H2F1 and GAP1/GRBC2; when associated with E-1999.
Reduction in the interaction with H2F1 and GAP1/GRBC2. Severe reduction in the interaction with H2F1 and GAP1/GRBC2; when associated with E-1998.
Severe reduction in the interaction with H2F1 and GAP1/GRBC2.
Bridge-like lipid transfer protein family member 1 N-terminal
Kinetoplast polyadenylation/uridylation factor 1
6-phosphogluconate dehydrogenase C-terminal
Protein OS9-like domain-containing protein
FAD/NAD(P)-binding domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Vacuolar transporter chaperone complex subunit 1
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPsynthase alpha/beta subunit N-terminal extension
Cilia- and flagella-associated protein 44
Large ribosomal subunit protein uL15/eL18
Cilia- and flagella-associated protein 43
Methionyl-tRNA synthetase anticodon-binding
Opioid growth factor receptor (OGFr) conserved
Non-canonical purine NTP phosphatase/PRRC1
Poly (ADP-ribose) glycohydrolase (PARG) catalytic
Expression site-associated gene 9 (ESAG9) protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
ATP-grasp fold succinyl-CoA synthetase-type
ARMET C-terminal domain-containing protein
Iron hydrogenase large subunit C-terminal
Tryptophan synthase beta chain-like PALP
Ubiquitin/SUMO-activating enzyme ubiquitin-like
Damage-control phosphatase ARMT1-like metal-binding
TFIIH basal transcription factor complex helicase XPB subunit
Small ribosomal subunit protein uS17 N-terminal
Phosphatidylcholine:ceramide cholinephosphotransferase 4
RNA editing 3' terminal uridylyl transferase 2 middle
Succinate dehydogenase/fumarate reductase N-terminal
GDP-locked, leading to impaired flagellum assembly. Unable to enter the flagellum and to interact with other IFT-B proteins.
Intraflagellar transport protein 27 homolog
Nucleoporin Nup133/Nup155-like N-terminal
Intraflagellar transport protein 56 homolog
Mitochondrial RNA binding complex 1 subunit
3-beta hydroxysteroid dehydrogenase/isomerase
Phosphatidylinositol-specific phospholipase C X
A-kinase anchor protein 7-like phosphoesterase
RNA-polymerase II-associated protein 3-like C-terminal
Deubiquitinating enzyme MINDY-3/4 conserved
Right handed beta helix domain-containing protein
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Activator of Hsp90 ATPase AHSA1-like N-terminal
Peroxisome membrane anchor protein Pex14p N-terminal
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Histone chaperone RTT106/FACT complex subunit SPT16-like middle
Alpha-glycerophosphate oxidase C-terminal
DNA replication complex GINS protein SLD5 C-terminal
Ubiquitin-activating enzyme E1 four-helix bundle
Manganese/iron superoxide dismutase N-terminal
Structure-specific endonuclease subunit SLX1 homolog
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein uL18 C-terminal eukaryotes
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
5-glutamyl glycerylphosphorylethanolamine
Phosphatidylcholine:ceramide cholinephosphotransferase 3
Trypanosome variant surface glycoprotein A-type N-terminal domain-containing protein
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA-directed DNA polymerase family A palm
Exocyst complex component Sec8 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Ribosomal RNA methyltransferase SPB1-like C-terminal
Sphingolipid delta4-desaturase N-terminal
Translation initiation factor beta propellor-like
Enriched in surface-labeled proteome protein 13
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Inositol 1,4,5-trisphosphate/ryanodine receptor
Large ribosomal subunit protein bL12 C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Vacuolar import/degradation Vid27 C-terminal
Phosphatidylethanolamine:ceramide ethanolaminephosphotransferase
Spindle assembly abnormal protein 6 N-terminal
Kinetoplastid DICER KptA ADP-ribosyltransferase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL4 C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Vacuolar protein sorting-associated protein 13 DH-like
Rad21/Rec8-like protein C-terminal eukaryotic
Prokaryotic-type class I peptide chain release factors domain-containing protein
Cytoplasmic tRNA 2-thiolation protein 1 C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Transcription elongation factor Spt6 YqgF
ATP-dependent protease ATPase subunit HslU1
DSC E3 ubiquitin ligase complex subunit 3 ubiquitin-like
Acyl-CoA dehydrogenase/oxidase N-terminal
Abnormal spindle-like microcephaly-associated protein ASH
Deoxyhypusine synthase regulatory subunit
Glycoside hydrolase family 31 N-terminal
Transcription factor IIB C-terminal module 1
Translation factor GUF1 homolog, mitochondrial
Phosphatidylinositol:ceramide inositolphosphotransferase
Coatomer beta subunit appendage platform
Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal
Translation elongation factor EFTs/EF1B dimerisation
Potassium channel tetramerisation-type BTB
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 central catalytic
DNA/pantothenate metabolism flavoprotein C-terminal
RNA 3'-terminal phosphate cyclase insert
Ciliary BBSome complex subunit 2 C-terminal
Ciliary BBSome complex subunit 2 N-terminal
Ciliary BBSome complex subunit 2 middle region
Glycylpeptide N-tetradecanoyltransferase C-terminal
Glycylpeptide N-tetradecanoyltransferase N-terminal