Reversibly protonated during proton transport
Anthranilate synthase component I N-terminal
DNA-directed DNA polymerase family A palm
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Essential for prephenate dehydratase activity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
NAD(P) transhydrogenase alpha subunit C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Nitrite/Sulfite reductase ferredoxin-like
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Alpha-D-phosphohexomutase alpha/beta/alpha
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Major facilitator superfamily (MFS) profile
Polypeptide-transport-associated ShlB-type
TonB-dependent receptor-like beta-barrel
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Type IV secretion system coupling protein TraD DNA-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
RND efflux pump membrane fusion protein barrel-sandwich
Heavy-metal-associated domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-methanol-choline oxidoreductase N-terminal
Resolvase/invertase-type recombinase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Mannose-6-phosphate isomerase type II C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Glycosyltransferase subfamily 4-like N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Outer membrane protein assembly factor BamD
Aminoacyl-transfer RNA synthetases class-II family profile
Interaction with polymerase core subunit RpoC
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Transcription elongation factor GreA/GreB C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
ABC-type transport auxiliary lipoprotein component
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Glycosyl transferase family 3 N-terminal
Penicillin-binding protein transpeptidase
Phosphoadenosine phosphosulphate reductase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glutamate synthase alpha subunit C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Polymerase/histidinol phosphatase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Survival protein SurE-like phosphatase/nucleotidase
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein uL15/eL18
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Prokaryotic-type class I peptide chain release factors
Poly-beta-hydroxybutyrate polymerase N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Pyruvate phosphate dikinase AMP/ATP-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Inner membrane protein YgaP-like transmembrane
DNA mismatch repair proteins mutS family
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Pseudouridine synthase I TruA alpha/beta
Phosphoribosylformylglycinamidine synthase linker
Bacterial type II secretion system protein E
NADH-rubredoxin oxidoreductase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Type II secretion system protein GspI C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glucose-methanol-choline oxidoreductase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cytochrome C biogenesis protein transmembrane
Carbamoyl-phosphate synthase small subunit N-terminal
LPXTG cell wall anchor domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Disulphide bond isomerase DsbC/G N-terminal
Exonuclease VII large subunit C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
Mandelate racemase/muconate lactonizing enzyme C-terminal
Flagellar basal body rod protein N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tryptophan synthase beta chain-like PALP
Nucleophile; cysteine thiosulfonate intermediate
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
ATP synthase F1 complex delta/epsilon subunit N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Translation elongation factor P/YeiP central
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
N-end rule aminoacyl transferase C-terminal
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
CagE TrbE VirB component of type IV transporter system central
Prepilin type IV endopeptidase peptidase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Histidine-specific methyltransferase SAM-dependent
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucan biosynthesis periplasmic MdoG C-terminal
Type II secretion system protein GspG C-terminal
RNA 2-O ribose methyltransferase substrate binding
Electron transfer via tryptophanyl radical
Membrane fusion protein biotin-lipoyl like
Flagellar basal-body/hook protein C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
O-(3'-phospho-DNA)-tyrosine intermediate
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
Cytochrome b561 bacterial/Ni-hydrogenase
Quercetin 2,3-dioxygenase C-terminal cupin
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Putative Flp pilus-assembly TadG-like N-terminal
Putative auto-transporter adhesin head GIN
Important for interaction with partner proteins
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Bacterial bifunctional deaminase-reductase C-terminal
General stress protein FMN-binding split barrel
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycine cleavage T-protein C-terminal barrel
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Tetrahydrodipicolinate-N-succinyltransferase chain A
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Large ribosomal subunit protein uL2 C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Polysaccharide chain length determinant N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cobaltochelatase subunit CobS N-terminal
DNA replication/recombination mediator RecO N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Cysteine sulfenic acid (-SOH) intermediate
Signal recognition particle SRP54 helical bundle
Pyrroline-5-carboxylate reductase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
tRNA pseudouridylate synthase B C-terminal
Plays an important role in substrate specificity
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Polysaccharide biosynthesis protein C-terminal
PhoD-like phosphatase metallophosphatase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glycine zipper domain-containing protein
Superoxide dismutase copper/zinc binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Membrane insertase YidC/Oxa/ALB C-terminal
CDP-alcohol phosphatidyltransferase C-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Transcription elongation factor GreA/GreB N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
CobB/CobQ-like glutamine amidotransferase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-100)
Secretin/TonB short N-terminal domain-containing protein
S-adenosylmethionine-dependent methyltransferase
Probable periplasmic serine endoprotease DegP-like
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribosomal RNA adenine methylase transferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
RNA binding; important for wobble base 34 recognition
Na+/H+ antiporter MnhB subunit-related protein
Small ribosomal subunit protein uS4 N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidase C14 caspase domain-containing protein
Magnesium transporter MgtE intracellular
S-adenosyl-L-homocysteine hydrolase NAD binding
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyrimidine nucleoside phosphorylase C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
YbgF trimerisation domain-containing protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Thymidylate synthase/dCMP hydroxymethylase
Large ribosomal subunit protein uL6 alpha-beta
Release factor glutamine methyltransferase N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Proton acceptor; for glutaminase activity
YbaK/aminoacyl-tRNA synthetase-associated
Chromosomal replication initiator protein DnaA
Flagellar motor switch protein FliN-like C-terminal
Outer membrane protein beta-barrel domain-containing protein
Biopterin-dependent aromatic amino acid hydroxylase family profile
Alanyl-transfer RNA synthetases family profile
PHA accumulation regulator DNA-binding N-terminal
Peptide methionine sulphoxide reductase MsrA
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Histidine phosphotransferase ChpT C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Important for beta-aspartyl-AMP intermediate formation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
RlpA-like protein double-psi beta-barrel
Right handed beta helix domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA topoisomerase I catalytic core eukaryotic-type
Heme-copper oxidase subunit III family profile