Aminoacyl-transfer RNA synthetases class-II family profile
Major facilitator superfamily (MFS) profile
Twin-arginine translocation pathway signal protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
UDP N-acetylglucosamine O-acyltransferase C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Peptide methionine sulphoxide reductase MsrA
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphoadenosine phosphosulphate reductase
Glycosyltransferase subfamily 4-like N-terminal
Flagellar motor switch protein FliN-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Alpha-D-phosphohexomutase alpha/beta/alpha
Solute-binding protein family 3/N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
ABC transporter substrate-binding protein PnrA-like
Pectate lyase superfamily protein domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
Tryptophan synthase beta chain-like PALP
CNP1-like uncharacterized domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
ABC transporter substrate-binding protein
O-(3'-phospho-DNA)-tyrosine intermediate
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
CobB/CobQ-like glutamine amidotransferase
Virulence factor membrane-bound polymerase C-terminal
Superoxide dismutase copper/zinc binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Helix-hairpin-helix DNA-binding motif class 1
Outer membrane protein assembly factor BamE
Positions MEP for the nucleophilic attack
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
PEP-CTERM protein-sorting domain-containing protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Pyruvate phosphate dikinase AMP/ATP-binding
Outer-membrane lipoprotein carrier protein
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Bacterial type II secretion system protein E
Resolvase/invertase-type recombinase catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Shikimate dehydrogenase substrate binding N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
S-adenosyl-L-homocysteine hydrolase NAD binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phenol hydroxylase C-terminal dimerisation
RNA 2-O ribose methyltransferase substrate binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Thiolase-like protein type 1 additional C-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Schiff-base intermediate with acetoacetate
C-type lysozyme inhibitor domain-containing protein
Chalcone isomerase domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Flagella basal body P-ring formation protein FlgA
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Pyruvate dehydrogenase E1 component middle
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cation-transporting P-type ATPase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Tetrahydrodipicolinate-N-succinyltransferase chain A
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Malonate/sodium symporter MadM subunit N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
RNA polymerase sigma factor 70 region 4 type 2
Interacts with tRNA; defines subfamily-specific binding signature
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
YVTN family beta-propeller domain-containing protein
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Exonuclease VII large subunit C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Could be important to modulate the pK values of the two catalytic cysteine residues
Biopterin-dependent aromatic amino acid hydroxylase family profile
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Interaction with polymerase core subunit RpoC
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycine zipper 2TM domain-containing protein
Type III secretion system flagellar brake protein YcgR PilZN
Type II secretion system protein GspC N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Flagellar basal body rod protein N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribosome maturation factor RimP N-terminal
S-adenosylmethionine-dependent methyltransferase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Poly-beta-hydroxybutyrate polymerase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alpha/beta hydrolase domain-containing protein
Mannose-6-phosphate isomerase type II C-terminal
Bacterial transcription activator effector binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Alpha-glycerophosphate oxidase C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Lipoprotein SmpA/OmlA domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Flagellar basal-body/hook protein C-terminal
Urease accessory protein UreH-like transmembrane
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
RNA binding; important for wobble base 34 recognition
Glycoside hydrolase family 31 N-terminal
Translation elongation factor P/YeiP central
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Alanyl-transfer RNA synthetases family profile
NADH:ubiquinone oxidoreductase 30kDa subunit
YbaK/aminoacyl-tRNA synthetase-associated
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Solute-binding protein family 3/N-terminal domain-containing protein
Type II secretion system protein GspG C-terminal
Phosphoethanolamine transferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pyridoxamine 5'-phosphate oxidase putative
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Na+/H+ antiporter MnhB subunit-related protein
TtsA-like Glycoside hydrolase family 108
Phosphate starvation-inducible protein PsiF
5-glutamyl coenzyme A thioester intermediate
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Type IV pilus biogenesis and competence protein PilQ
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
C4-dicarboxylate ABC transporter substrate-binding protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Phosphotransferase system enzyme I N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cysteine sulfenic acid (-SOH) intermediate
Bacterial virulence domain-containing protein
Prokaryotic-type class I peptide chain release factors
Inner membrane protein YgaP-like transmembrane
Lipocalin/cytosolic fatty-acid binding domain-containing protein
AB hydrolase-1 domain-containing protein
Chromosomal replication initiator protein DnaA
Tripartite tricarboxylate transporter substrate binding protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Transposase IS204/IS1001/IS1096/IS1165 DDE
Membrane fusion protein biotin-lipoyl like
Aspartate/homoserine dehydrogenase NAD-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Haem-binding uptake Tiki superfamily ChaN
Haem-binding uptake Tiki superfamily ChaN domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Molybdopterin cofactor biosynthesis C (MoaC)
Penicillin-binding protein transpeptidase
Outer membrane protein assembly factor BamB
Anthranilate synthase component I N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA polymerase III subunit delta C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA topoisomerase I catalytic core eukaryotic-type
Terminase large subunit-like endonuclease
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Adaptive response protein AidB N-terminal
TonB-dependent receptor-like beta-barrel
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Lipopolysaccharide assembly protein A domain-containing protein
Prepilin type IV endopeptidase peptidase
Xaa-Pro dipeptidyl-peptidase-like domain-containing protein
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Ionotropic glutamate receptor C-terminal
Proton acceptor; for glutaminase activity
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Glycine cleavage T-protein C-terminal barrel
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Gamma-glutamylcyclotransferase AIG2-like
O-(phosphoribosyl dephospho-coenzyme A)serine
O-(5'-phospho-DNA)-tyrosine intermediate
Ribose-phosphate pyrophosphokinase N-terminal
Plays an important role in substrate specificity
Outer membrane protein beta-barrel domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
Polysaccharide biosynthesis protein CapD-like
Phosphatidylglycerol lysyltransferase C-terminal
Putative regulatory protein FmdB Zinc ribbon
Quercetin 2,3-dioxygenase C-terminal cupin
Large ribosomal subunit protein uL2 C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Spore coat protein U domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
Peptidase C-terminal archaeal/bacterial domain-containing protein
Inosine/uridine-preferring nucleoside hydrolase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)
Phospholipid transport system substrate-binding protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Polysaccharide chain length determinant N-terminal
Outer membrane protein assembly factor BamA
SsuA/THI5-like domain-containing protein
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Lipocalin-like domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Flagellar hook-length control protein-like C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
PHA accumulation regulator DNA-binding N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Heme-copper oxidase subunit III family profile
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein uL15/eL18
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Important for beta-aspartyl-AMP intermediate formation
Gly-cisPro motif, important for rejection of L-amino acids
Toxin-antitoxin system YwqK family antitoxin
DNA-directed DNA polymerase family A palm
Saccharopine dehydrogenase-like C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ribosomal RNA small subunit methyltransferase E methyltransferase
Surface antigen domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
serine-type D-Ala-D-Ala carboxypeptidase
General stress protein FMN-binding split barrel
N-end rule aminoacyl transferase C-terminal
Outer membrane protein assembly factor BamD
Pseudouridine synthase I TruA alpha/beta
Phage terminase large subunit N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Integral membrane protein YccS N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Electron transfer via tryptophanyl radical
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Blue (type 1) copper domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
6-phosphogluconate dehydrogenase C-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Carboxypeptidase regulatory-like domain-containing protein
NAD(P) transhydrogenase alpha subunit C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Important for interaction with partner proteins
Type II secretion system protein GspI C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Proline utilization A proline dehydrogenase N-terminal
DNA mismatch repair proteins mutS family
Reversibly protonated during proton transport
DNA replication/recombination mediator RecO N-terminal
NIF system FeS cluster assembly NifU N-terminal
Twin-arginine translocation pathway signal
High potential iron-sulfur proteins family profile
Signal transduction histidine kinase internal region
Outer membrane protein OmpA-like transmembrane
Outer membrane protein OmpA-like transmembrane domain-containing protein
Required for zinc-mediated homotetramerization and catalytic activity
Essential for prephenate dehydratase activity
Histidine kinase domain-containing protein