Aminoacyl-transfer RNA synthetases class-II family profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
O-(5'-phospho-DNA)-tyrosine intermediate
RNA 2-O ribose methyltransferase substrate binding
Solute-binding protein family 3/N-terminal
Electron transfer via tryptophanyl radical
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Large ribosomal subunit protein uL6 alpha-beta
Major facilitator superfamily (MFS) profile
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
TonB-dependent receptor-like beta-barrel
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Outer membrane protein assembly factor BamB
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Peptidase S9 prolyl oligopeptidase catalytic
Threonine/serine exporter-like N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphatidic acid phosphatase type 2/haloperoxidase
Glucose-methanol-choline oxidoreductase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Integral membrane protein YccS N-terminal
Phosphocysteine intermediate; for EIIB activity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Cytochrome b561 bacterial/Ni-hydrogenase
Superoxide dismutase copper/zinc binding
Tryptophan synthase beta chain-like PALP
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Membrane fusion protein biotin-lipoyl like
Type II secretion system protein GspG C-terminal
Important for beta-aspartyl-AMP intermediate formation
Molybdopterin cofactor biosynthesis C (MoaC)
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Alanyl-transfer RNA synthetases family profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Schiff-base intermediate with acetaldehyde
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
NADH:ubiquinone oxidoreductase 30kDa subunit
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Heme-copper oxidase subunit III family profile
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Survival protein SurE-like phosphatase/nucleotidase
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Outer membrane protein assembly factor BamE
Appears to be important in orienting the phosphate for catalysis
Ion-translocating oxidoreductase complex subunit G
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
O-(phosphoribosyl dephospho-coenzyme A)serine
Prepilin peptidase dependent protein C-like C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Polymerase/histidinol phosphatase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Mannose-6-phosphate isomerase type II C-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
RNA binding; important for wobble base 34 recognition
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Ionotropic glutamate receptor C-terminal
Membrane-bound lytic murein transglycosylase C
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Penicillin-insensitive murein endopeptidase
Curli production assembly/transport component CsgF
Curli production assembly/transport component CsgG
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Non-canonical purine NTP phosphatase/PRRC1
Large ribosomal subunit protein uL2 C-terminal
Positions MEP for the nucleophilic attack
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Type II secretion system protein GspI C-terminal
Phosphoethanolamine transferase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Outer-membrane lipoprotein carrier protein
Essential for degradation by Lon protease
Interacts with tRNA; defines subfamily-specific binding signature
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Important for interaction with partner proteins
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Outer membrane protein assembly factor BamD
Membrane insertase YidC/Oxa/ALB C-terminal
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Important for substrate binding and specificity
Helix-hairpin-helix DNA-binding motif class 1
Gly-cisPro motif, important for rejection of L-amino acids
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein bL25 L25
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Phosphotransferase system enzyme I N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Mechanosensitive ion channel inner membrane
Gamma-glutamylcyclotransferase AIG2-like
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
RNA polymerase sigma factor 70 region 4 type 2
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
DnaJ homologue subfamily C member 28 conserved
Bacterial transcription activator effector binding
RNA methyltransferase SpoU/TrmH type C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Translation elongation factor P/YeiP central
Could play a key role in the communication between the regulatory and the substrate sites
Curli production assembly/transport component CsgE
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Polysaccharide chain length determinant N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Flagellar motor switch protein FliN-like C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycosyltransferase subfamily 4-like N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Peptide methionine sulphoxide reductase MsrA
Reversibly protonated during proton transport
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
ABC-type glycine betaine transport system substrate-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Penicillin-binding protein transpeptidase
Aspartate/homoserine dehydrogenase NAD-binding
NIF system FeS cluster assembly NifU C-terminal
Transcription elongation factor GreA/GreB N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Nitrite/Sulfite reductase ferredoxin-like
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Involved in tetramerization or stability of the tetramer
Nucleoside-specific channel-forming protein Tsx
Glucan biosynthesis periplasmic MdoG C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Prokaryotic-type class I peptide chain release factors
Plays an important role in substrate specificity
YbaK/aminoacyl-tRNA synthetase-associated
Ribose-phosphate pyrophosphokinase N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Disulphide bond isomerase DsbC/G N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Outer membrane protein assembly factor BamA
Greasy slide, important in sugar transport
Thiol:disulfide interchange protein DsbD
NIF system FeS cluster assembly NifU N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Pyruvate dehydrogenase E1 component middle
Cysteine sulfenic acid (-SOH) intermediate
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Menaquinone biosynthesis protein MenD middle
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Essential for prephenate dehydratase activity
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein uL15/eL18
D-galactose/methyl-galactoside binding periplasmic protein MglB
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Flagellar motor switch protein FliN N-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Involved in allosteric activation by GTP
Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with Met-252)
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-105)
DNA replication/recombination mediator RecO N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Glycosyl transferase family 3 N-terminal
Chromosomal replication initiator DnaA C-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Sodium/calcium exchanger membrane region
DNA polymerase III subunit delta C-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Proline utilization A proline dehydrogenase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Ribosomal RNA adenine methylase transferase N-terminal
Interaction with tRNA. Important for base-flipping
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Arginine decarboxylase C-terminal helical