FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Polymerase/histidinol phosphatase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Adaptive response protein AidB N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Threonine/serine exporter-like N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Mycothiol-dependent maleylpyruvate isomerase metal-binding
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Methionyl-tRNA synthetase anticodon-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Cell envelope-related transcriptional attenuator
DNA replication/recombination mediator RecO N-terminal
Cytochrome b/b6 N-terminal region profile
Major facilitator superfamily (MFS) profile
Glycosyltransferase subfamily 4-like N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Large ribosomal subunit protein bL12 C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Phosphotransferase system enzyme I N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptide methionine sulphoxide reductase MsrA
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Bacterial bifunctional deaminase-reductase C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glycosyltransferase family 28 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Tryptophan synthase beta chain-like PALP
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycine cleavage T-protein C-terminal barrel
Ionotropic glutamate receptor C-terminal
ABC transporter substrate-binding protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
6-phosphogluconate dehydrogenase C-terminal
Saccharopine dehydrogenase-like C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Exonuclease VII large subunit C-terminal
Schiff-base intermediate with acetaldehyde
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alanyl-transfer RNA synthetases family profile
Large ribosomal subunit protein uL6 alpha-beta
ABC-type glycine betaine transport system substrate-binding
ABC-type glycine betaine transport system substrate-binding domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Phosphomannose isomerase type I catalytic
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cation-transporting P-type ATPase N-terminal
Peptidase C39-like domain-containing protein
Transglycosylase SLT domain-containing protein
Dihydrodipicolinate reductase N-terminal
Thiolase-like protein type 1 additional C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Homogentisate 1,2-dioxygenase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Choloylglycine hydrolase/NAAA C-terminal
Transcription elongation factor GreA/GreB C-terminal
Glycoside hydrolase family 42 N-terminal
Glycoside hydrolase family 42 N-terminal domain-containing protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Prokaryotic-type class I peptide chain release factors
Penicillin-binding protein transpeptidase
Aminoacyl-tRNA synthetase class I anticodon-binding
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Polysaccharide chain length determinant N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Large ribosomal subunit protein uL15/eL18
Resolvase/invertase-type recombinase catalytic
NAD(P) transhydrogenase alpha subunit C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-112)
Pseudouridine synthase I TruA alpha/beta
Solute-binding protein family 5 domain-containing protein
Prepilin type IV endopeptidase peptidase
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Transmembrane alanine and glycine rich protein
O-(3'-phospho-DNA)-tyrosine intermediate
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Proton acceptor; for glutaminase activity
TRAP C4-dicarboxylate transport system permease DctM subunit
Carbamoyl-phosphate synthase small subunit N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glucose-methanol-choline oxidoreductase C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Small ribosomal subunit protein uS4 N-terminal
Histidine-specific methyltransferase SAM-dependent
O-(5'-phospho-DNA)-tyrosine intermediate
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
L,D-transpeptidase catalytic domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Beta-lactamase class A catalytic domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Alpha-glycerophosphate oxidase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
NADH-rubredoxin oxidoreductase C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Essential for prephenate dehydratase activity
Transcription regulator AsnC/Lrp ligand binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
4'-phosphopantetheinyl transferase N-terminal
Glycosyl transferase family 3 N-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Molybdopterin cofactor biosynthesis C (MoaC)
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Thymidylate synthase/dCMP hydroxymethylase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Polysaccharide biosynthesis protein C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Large ribosomal subunit protein uL2 C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Rv2525c-like glycoside hydrolase-like domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Styrene monooxygenase StyA putative substrate binding
Superoxide dismutase copper/zinc binding
Resuscitation-promoting factor core lysozyme-like
NIF system FeS cluster assembly NifU N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Reversibly protonated during proton transport
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Type II secretion system protein GspF domain-containing protein
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Pyruvate dehydrogenase E1 component middle
Peptidase S9 prolyl oligopeptidase catalytic
Cytochrome bc1 complex cytochrome c subunit
Glycosyl transferase family 28 C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Translation elongation factor P/YeiP central
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Schiff-base intermediate with substrate; via topaquinone
Membrane insertase YidC/Oxa/ALB C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Shikimate dehydrogenase substrate binding N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Cytochrome oxidase subunit II copper A binding
Putative regulatory protein FmdB Zinc ribbon
Heme-copper oxidase subunit III family profile
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Sodium/calcium exchanger membrane region
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein bL12 oligomerization
Myo-inositol-1-phosphate synthase GAPDH-like
Exported alanine and valine rich protein
Phosphatidic acid phosphatase type 2/haloperoxidase
ESX-1 secretion-associated protein EspB PE
Anthranilate synthase component I N-terminal
3-beta hydroxysteroid dehydrogenase/isomerase
RNA 2-O ribose methyltransferase substrate binding
Quercetin 2,3-dioxygenase C-terminal cupin
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Ribosome maturation factor RimP N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Transcription elongation factor GreA/GreB N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Peptidase M1 membrane alanine aminopeptidase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphodiester glycosidase domain-containing protein
ESX-1 secretion-associated protein EspA/EspE-like
Putative oxidoreductase/dehydrogenase Rossmann-like
Plays an important role in substrate specificity
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Moves into active site upon enzyme activation, plays a role in electron transfer
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Dihydrodipicolinate reductase C-terminal
Phosphocysteine intermediate; for EIIB activity
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Cytochrome C biogenesis protein transmembrane
Endoribonuclease L-PSP/chorismate mutase-like
ATP synthase F1 complex delta/epsilon subunit N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Transposase IS116/IS110/IS902 C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Could be important to modulate the pK values of the two catalytic cysteine residues
Release factor glutamine methyltransferase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Chromosomal replication initiator DnaA C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
YbaK/aminoacyl-tRNA synthetase-associated
Acyltransferase MbtK/IucB-like conserved
DNA-directed DNA polymerase family A palm
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Phosphoribosylformylglycinamidine synthase linker
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Peptidoglycan recognition protein family
Bacterial type II secretion system protein E
Interaction with polymerase core subunit RpoC