Pyridine nucleotide-disulphide oxidoreductase dimerisation
Aminoacyl-transfer RNA synthetases class-II family profile
6-phosphogluconate dehydrogenase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Release factor glutamine methyltransferase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Major facilitator superfamily (MFS) profile
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pyridoxamine 5'-phosphate oxidase putative
Tryptophan synthase beta chain-like PALP
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycosyltransferase subfamily 4-like N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glycosyltransferase family 28 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Involved in ionization of N3 of dUMP, leading to its activation
Transposase IS116/IS110/IS902 C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
NADH:ubiquinone oxidoreductase-like 20kDa subunit
PknH-like extracellular domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
CobB/CobQ-like glutamine amidotransferase
Ribose-phosphate pyrophosphokinase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
FAD-dependent oxidoreductase 2 FAD binding
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Penicillin-binding protein transpeptidase
Cytochrome C biogenesis protein transmembrane
Reversibly protonated during proton transport
Nitrite/Sulfite reductase ferredoxin-like
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RNA 2-O ribose methyltransferase substrate binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Styrene monooxygenase StyA putative substrate binding
Plays an important role in substrate specificity
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
ESX-1 secretion-associated protein EspA/EspE-like
Putative oxidoreductase/dehydrogenase Rossmann-like
DNA-directed DNA polymerase family A palm
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
O-(5'-phospho-DNA)-tyrosine intermediate
Methylguanine DNA methyltransferase ribonuclease-like
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Peptide methionine sulphoxide reductase MsrA
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Gly-cisPro motif, important for rejection of L-amino acids
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
SsuA/THI5-like domain-containing protein
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Putative glycogen debranching enzyme N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Prokaryotic-type class I peptide chain release factors
Cysteine sulfenic acid (-SOH) intermediate
S-adenosyl-L-homocysteine hydrolase NAD binding
Essential for prephenate dehydratase activity
Glucosamine/galactosamine-6-phosphate isomerase
Adaptive response protein AidB N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cation-transporting P-type ATPase C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Protein O-mannosyl-transferase C-terminal four TM
Superoxide dismutase copper/zinc binding
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Peptidase M15C domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alpha-glycerophosphate oxidase C-terminal
PhoD-like phosphatase metallophosphatase
Chromosomal replication initiator DnaA C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Putative Flp pilus-assembly TadG-like N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL15/eL18
Polymerase/histidinol phosphatase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glycosyl transferase family 28 C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Dihydrodipicolinate reductase C-terminal
Proton acceptor; for glutaminase activity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Thiolase-like protein type 1 additional C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
DNA topoisomerase I catalytic core eukaryotic-type
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Exonuclease VII large subunit C-terminal
Haemophore haem-binding domain-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
SUF system FeS cluster assembly SufBD N-terminal
Glucose-methanol-choline oxidoreductase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Translation elongation factor P/YeiP central
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein uL6 alpha-beta
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Shikimate dehydrogenase substrate binding N-terminal
Phosphoribosylformylglycinamidine synthase linker
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Thioredoxin-like fold domain-containing protein
Cation-transporting P-type ATPase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Methionyl-tRNA synthetase anticodon-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Phosphomannose isomerase type I catalytic
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL2 C-terminal
Threonine/serine exporter-like N-terminal
Schiff-base intermediate with acetaldehyde
Small ribosomal subunit protein uS4 N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Glucose-methanol-choline oxidoreductase C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Transcription elongation factor GreA/GreB C-terminal
Resolvase/invertase-type recombinase catalytic
DNA replication/recombination mediator RecO N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Peptidase M1 membrane alanine aminopeptidase
Cell envelope-related transcriptional attenuator
Acyltransferase MbtK/IucB-like conserved
Heat-inducible transcription repressor HrcA C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Important for beta-aspartyl-AMP intermediate formation
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
ABC-type glycine betaine transport system substrate-binding
Anti-sigma-D factor RsdA sigma factor binding region
3-beta hydroxysteroid dehydrogenase/isomerase
Histidine-specific methyltransferase SAM-dependent
Na+/H+ antiporter MnhB subunit-related protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Activator of Hsp90 ATPase homologue 1-like C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Endoribonuclease L-PSP/chorismate mutase-like
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Pyrimidine nucleoside phosphorylase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Transcription elongation factor GreA/GreB N-terminal
Exported alanine and valine rich protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
Schiff-base intermediate with substrate; via pyruvic acid
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Pyruvate dehydrogenase E1 component middle
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Alanine and proline-rich secreted protein Apa
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
ESX-1 secretion-associated protein EspB PE
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation