Resolvase/invertase-type recombinase catalytic
Polymerase/histidinol phosphatase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Flavodoxin-like domain-containing protein
ABC transporter substrate-binding protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
DNA-directed DNA polymerase family A palm
Gram-positive cocci surface proteins LPxTG
Gram-positive cocci surface proteins LPxTG domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Major facilitator superfamily (MFS) profile
Phosphomannose isomerase type I catalytic
Signal transduction histidine kinase internal region
Involved in allosteric activation by GTP
Prokaryotic-type class I peptide chain release factors
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
RNA polymerase sigma factor 70 region 4 type 2
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Helix-turn-helix conjugative transposon-like
Phage terminase large subunit N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Release factor glutamine methyltransferase N-terminal
Carbohydrate ABC transporter substrate-binding protein
HicB-like antitoxin of toxin-antitoxin system
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Sugar fermentation stimulation protein C-terminal
Cation-transporting P-type ATPase N-terminal
Transglutaminase-like domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Protein O-mannosyl-transferase C-terminal four TM
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glycoside hydrolase family 42 N-terminal
Schiff-base intermediate with acetaldehyde
Aminoacyl-tRNA synthetase class I anticodon-binding
Transposase IS116/IS110/IS902 C-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Diacylglycerol glucosyltransferase N-terminal
Translation elongation factor P/YeiP central
Aspartate/homoserine dehydrogenase NAD-binding
NIF system FeS cluster assembly NifU N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Ricin B lectin domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Bacterial type II secretion system protein E
CobB/CobQ-like glutamine amidotransferase
Alanyl-transfer RNA synthetases family profile
Pyrimidine nucleoside phosphorylase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Penicillin-binding protein transpeptidase
Glutamate synthase alpha subunit C-terminal
Flagellar motor switch protein FliN-like C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Peptidase S9 prolyl oligopeptidase catalytic
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Solute-binding protein family 5 domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Glycoside hydrolase family 31 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL2 C-terminal
Interaction with polymerase core subunit RpoC
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
YcxB-like protein domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Cell envelope-related transcriptional attenuator
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Prealbumin-like fold domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA mismatch repair proteins mutS family
Choloylglycine hydrolase/NAAA C-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Sugar ABC transporter substrate-binding protein
Glycosyltransferase subfamily 4-like N-terminal
Important for interaction with partner proteins
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Bacterial bifunctional deaminase-reductase C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein uL15/eL18
Involved in ionization of N3 of dUMP, leading to its activation
Sporulation stage IV protein A C-terminal
Proton acceptor; for glutaminase activity
Could play a key role in the communication between the regulatory and the substrate sites
Dihydrodipicolinate reductase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Major facilitator superfamily associated
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Small ribosomal subunit protein uS4 N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Threonine/serine exporter-like N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Flagellar assembly protein FliH/Type III secretion system HrpE
Copper amine oxidase-like N-terminal domain-containing protein
Pyruvate phosphate dikinase AMP/ATP-binding
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Glycosyl-4,4'-diaponeurosporenoate acyltransferase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Ribosome maturation factor RimP N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA pseudouridylate synthase B C-terminal
Phosphotransferase system enzyme I N-terminal
S-adenosylmethionine-dependent methyltransferase
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Shikimate dehydrogenase substrate binding N-terminal
Pseudouridine synthase I TruA alpha/beta
RNA 2-O ribose methyltransferase substrate binding
N-sulphoglucosamine sulphohydrolase C-terminal
Alpha galactosidase C-terminal beta sandwich
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Peptidase M10 metallopeptidase domain-containing protein
Sodium/calcium exchanger membrane region
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Flagellar hook-length control protein-like C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Alpha-L-glutamate ligase-related protein ATP-grasp
Ribosomal RNA adenine methylase transferase N-terminal
ABC-type uncharacterised transport system
Defence against restriction A C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Sigma 54 modulation/S30EA ribosomal protein C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Inosine monophosphate cyclohydrolase-like
Polysaccharide biosynthesis protein C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Plays an important role in substrate specificity
Fe/B12 periplasmic-binding domain-containing protein
Transcription regulator AsnC/Lrp ligand binding
Phosphoribosylformylglycinamidine synthase linker
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Dipicolinate synthase subunit A N-terminal
Exonuclease VII large subunit C-terminal
Phosphoadenosine phosphosulphate reductase
Could be important to modulate the pK values of the two catalytic cysteine residues
Survival protein SurE-like phosphatase/nucleotidase
Inosine/uridine-preferring nucleoside hydrolase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Lipocalin-like domain-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal