3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glycosyltransferase family 28 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Major facilitator superfamily (MFS) profile
Glycosyltransferase subfamily 4-like N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL15/eL18
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glucosamine/galactosamine-6-phosphate isomerase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycine cleavage T-protein C-terminal barrel
Alpha-glycerophosphate oxidase C-terminal
Peptidoglycan recognition protein family
Protein O-mannosyl-transferase C-terminal four TM
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Alanine and proline-rich secreted protein Apa
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Transposase IS116/IS110/IS902 C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
6-phosphogluconate dehydrogenase C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Tryptophan synthase beta chain-like PALP
Aminoacyl-transfer RNA synthetases class-II family profile
Resolvase/invertase-type recombinase catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Peptide methionine sulphoxide reductase MsrA
MmyB-like transcription regulator ligand binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
N-sulphoglucosamine sulphohydrolase C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Prokaryotic-type class I peptide chain release factors
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Peptidase M1 membrane alanine aminopeptidase
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Small ribosomal subunit protein uS4 N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Acyltransferase MbtK/IucB-like conserved
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Schiff-base intermediate with acetaldehyde
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Solute-binding protein family 3/N-terminal
RNA 2-O ribose methyltransferase substrate binding
Pyruvate phosphate dikinase AMP/ATP-binding
Glucose-methanol-choline oxidoreductase C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Phosphomannose isomerase type I catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Moves into active site upon enzyme activation, plays a role in electron transfer
DNA-directed DNA polymerase family A palm
Peptidase S9 prolyl oligopeptidase catalytic
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
ABC-type glycine betaine transport system substrate-binding
CobB/CobQ-like glutamine amidotransferase
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Adaptive response protein AidB N-terminal
4'-phosphopantetheinyl transferase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Methionyl-tRNA synthetase anticodon-binding
Formamidopyrimidine-DNA glycosylase catalytic
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Penicillin-binding protein transpeptidase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Polysaccharide biosynthesis protein C-terminal
Plays an important role in substrate specificity
Cytochrome C biogenesis protein transmembrane
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Carbamoyl-phosphate synthase small subunit N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Pyruvate dehydrogenase E1 component middle
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Pyrimidine nucleoside phosphorylase C-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Phosphoribosylformylglycinamidine synthase linker
ESX-1 secretion-associated protein EspB PE
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
S-adenosyl-L-homocysteine hydrolase NAD binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
AraC-type arabinose-binding/dimerisation
Glucose-methanol-choline oxidoreductase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Transcription regulator AsnC/Lrp ligand binding
DNA topoisomerase I catalytic core eukaryotic-type
N,N-dimethylformamidase beta subunit-like C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Pyrroline-5-carboxylate reductase catalytic N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Heme-copper oxidase subunit III family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Cytochrome b/b6 N-terminal region profile
Bacterial type II secretion system protein E
Myo-inositol-1-phosphate synthase GAPDH-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cell envelope-related transcriptional attenuator
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-113)
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Essential for prephenate dehydratase activity
Phosphoadenosine phosphosulphate reductase
Involved in ionization of N3 of dUMP, leading to its activation
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-123)
Gly-cisPro motif, important for rejection of L-amino acids
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
SUF system FeS cluster assembly SufBD N-terminal
Thiolase-like protein type 1 additional C-terminal
NIF system FeS cluster assembly NifU N-terminal
Superoxide dismutase copper/zinc binding
Glycosyl transferase family 28 C-terminal
Glutamate synthase alpha subunit C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Moybdenum cofactor oxidoreductase dimerisation
Important for beta-aspartyl-AMP intermediate formation
Homogentisate 1,2-dioxygenase N-terminal
Exonuclease VII large subunit C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Proton acceptor; for glutaminase activity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Polyketide synthase phosphopantetheine-binding
Methylguanine DNA methyltransferase ribonuclease-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Reversibly protonated during proton transport
Removed in mature form; by autocatalysis
Threonine/serine exporter-like N-terminal
Anthranilate synthase component I N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Schiff-base intermediate with substrate; via topaquinone
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Alanyl-transfer RNA synthetases family profile
Quercetin 2,3-dioxygenase C-terminal cupin
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Translation elongation factor P/YeiP central
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA replication/recombination mediator RecO N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
ESX-1 secretion-associated protein EspA/EspE-like
Acetyl-CoA hydrolase/transferase C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Ribose-phosphate pyrophosphokinase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB
Dihydrodipicolinate reductase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Large ribosomal subunit protein uL2 C-terminal