NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Integral membrane protein YccS N-terminal
Flagellar motor switch protein FliN-like C-terminal
Reversibly protonated during proton transport
Phosphocysteine intermediate; for EIIB activity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Major facilitator superfamily (MFS) profile
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Polysaccharide chain length determinant N-terminal
Solute-binding protein family 3/N-terminal
TonB-dependent receptor-like beta-barrel
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Cation-transporting P-type ATPase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pseudouridine synthase I TruA alpha/beta
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Flagellar basal body rod protein N-terminal
Outer-membrane lipoprotein carrier protein
O-(3'-phospho-DNA)-tyrosine intermediate
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Pyruvate dehydrogenase E1 component middle
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
RNA polymerase sigma factor 70 region 4 type 2
RND efflux pump membrane fusion protein barrel-sandwich
Penicillin-binding protein transpeptidase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glucosamine/galactosamine-6-phosphate isomerase
Organic solvent tolerance-like N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Outer membrane protein assembly factor BamA
Disulphide bond isomerase DsbC/G N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Helix-hairpin-helix DNA-binding motif class 1
Aminoacyl-transfer RNA synthetases class-II family profile
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Flagellar basal-body/hook protein C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Chromosomal replication initiator protein DnaA
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for substrate binding and specificity
ABC-type glycine betaine transport system substrate-binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Interaction with polymerase core subunit RpoC
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Arginine decarboxylase C-terminal helical
Polymerase/histidinol phosphatase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
RNA 2-O ribose methyltransferase substrate binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Endolytic peptidoglycan transglycosylase RlpA
Polypeptide-transport-associated ShlB-type
Ionotropic glutamate receptor C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Survival protein SurE-like phosphatase/nucleotidase
Mechanosensitive ion channel inner membrane
Aconitase A/isopropylmalate dehydratase small subunit swivel
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
6-phosphogluconate dehydrogenase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
O-(5'-phospho-DNA)-tyrosine intermediate
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Heme-copper oxidase subunit III family profile
Essential for prephenate dehydratase activity
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Catalytic role in ketonization of the dienol substrate (substrate destabilization)
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
DNA polymerase III delta subunit C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
NIF system FeS cluster assembly NifU C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Membrane fusion protein biotin-lipoyl like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Putative regulatory protein FmdB Zinc ribbon
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribosomal RNA adenine methylase transferase N-terminal
Sodium/calcium exchanger membrane region
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
N-end rule aminoacyl transferase C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Exonuclease VII large subunit C-terminal
Bacterial transcription activator effector binding
Bacterial type II secretion system protein E
Type II secretion system protein GspI C-terminal
7 transmembrane helices usually fused to an inactive transglutaminase
Inactive transglutaminase fused to 7 transmembrane helices
Ribose-phosphate pyrophosphokinase N-terminal
Lipopolysaccharide export system protein LptA
Translation elongation factor P/YeiP central
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
UDP N-acetylglucosamine O-acyltransferase C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Glycine cleavage T-protein C-terminal barrel
Transposase IS204/IS1001/IS1096/IS1165 DDE
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
DNA mismatch repair proteins mutS family
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Required for zinc-mediated homotetramerization and catalytic activity
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Anthranilate synthase component I N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Seems to be a necessary countercharge to the potassium cations
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Tryptophan synthase beta chain-like PALP
NIF system FeS cluster assembly NifU N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Prokaryotic-type class I peptide chain release factors
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose-6-phosphate isomerase prokaryote
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Type III secretion system flagellar brake protein YcgR PilZN
Biopterin-dependent aromatic amino acid hydroxylase family profile
Alpha-glycerophosphate oxidase C-terminal
Plays an important role in substrate specificity
Outer membrane protein assembly factor BamB
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
S-adenosylmethionine-dependent methyltransferase
Aminoacyl-tRNA synthetase class I anticodon-binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Type II secretion system protein GspG C-terminal
Involved in tetramerization or stability of the tetramer
Small ribosomal subunit protein uS4 N-terminal
Peptide methionine sulphoxide reductase MsrA
Chromosomal replication initiator DnaA C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Erythronate-4-phosphate dehydrogenase dimerisation
Prepilin type IV endopeptidase peptidase
Phosphoadenosine phosphosulphate reductase
Saccharopine dehydrogenase-like C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Urease accessory protein UreH-like transmembrane
Transcription factor NikR nickel binding C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Alpha-D-phosphohexomutase alpha/beta/alpha
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Sugar fermentation stimulation protein C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Putative beta-barrel assembly-enhancing protease
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA replication/recombination mediator RecO N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Nucleophile; cysteine thiosulfonate intermediate
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Transcription elongation factor GreA/GreB N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cytochrome b561 bacterial/Ni-hydrogenase
Interacts with tRNA; defines subfamily-specific binding signature
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
RlpA-like protein double-psi beta-barrel
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Cob(I)alamin adenosyltransferase N-terminal
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Phosphatidylglycerol lysyltransferase C-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria