Major facilitator superfamily (MFS) profile
Translation elongation factor P/YeiP central
4'-phosphopantetheinyl transferase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Arabinogalactan endo-beta-1,4-galactanase
Gfo/Idh/MocA-like oxidoreductase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Alpha-D-phosphohexomutase alpha/beta/alpha
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA-directed DNA polymerase family A palm
RNA polymerase sigma factor 70 region 4 type 2
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Phosphoadenosine phosphosulphate reductase
Probable transposase IS891/IS1136/IS1341
Beta-xylosidase C-terminal Concanavalin A-like
NIF system FeS cluster assembly NifU C-terminal
Peptidoglycan binding-like domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Gfo/Idh/MocA-like oxidoreductase C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Bacterial bifunctional deaminase-reductase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Putative glycogen debranching enzyme N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Peptidase M1 membrane alanine aminopeptidase
Polymerase/histidinol phosphatase N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Phosphatidic acid phosphatase type 2/haloperoxidase
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Penicillin-binding protein transpeptidase
Sugar ABC transporter substrate-binding protein
Peptidase S9 prolyl oligopeptidase catalytic
SGNH hydrolase-type esterase domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glycoside-hydrolase family GH114 TIM-barrel
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Essential for prephenate dehydratase activity
Transition state stabilizer; via amide nitrogen
Mycothiol-dependent maleylpyruvate isomerase metal-binding
RNA 2-O ribose methyltransferase substrate binding
Pyridoxamine 5'-phosphate oxidase putative
Carbamoyl-phosphate synthase small subunit N-terminal
Lipocalin-like domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Putative oxidoreductase/dehydrogenase Rossmann-like
Phosphomannose isomerase type I catalytic
L,D-transpeptidase catalytic domain-containing protein
Removed in mature form; by autocatalysis
TRAP ABC transporter substrate-binding protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Alpha-L-arabinofuranosidase B arabinose-binding
Glycine cleavage T-protein C-terminal barrel
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Heavy metal-binding domain-containing protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
Acyltransferase MbtK/IucB-like conserved
Formamidopyrimidine-DNA glycosylase catalytic
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Right handed beta helix domain-containing protein
Resolvase/invertase-type recombinase catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Cell envelope-related transcriptional attenuator
6-phosphogluconate dehydrogenase C-terminal
Glycerophosphoryl diester phosphodiesterase family protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Tryptophan synthase beta chain-like PALP
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Pyrimidine nucleoside phosphorylase C-terminal
Peptidase C39-like domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Myo-inositol-1-phosphate synthase GAPDH-like
Glycerophosphoryl diester phosphodiesterase membrane
S-adenosyl-L-homocysteine hydrolase NAD binding
Nucleophile; cysteine thiosulfonate intermediate
Mandelate racemase/muconate lactonizing enzyme C-terminal
Reversibly protonated during proton transport
TIGR04222 domain-containing membrane protein
ABC-type glycine betaine transport system substrate-binding
Exonuclease VII large subunit C-terminal
Methionyl-tRNA synthetase anticodon-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Gly-cisPro motif, important for rejection of L-amino acids
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Histidine-specific methyltransferase SAM-dependent
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
PknH-like extracellular domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL6 alpha-beta
LPXTG cell wall anchor domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Glycosyl transferase family 3 N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Saccharopine dehydrogenase-like C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-109)
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Peptidoglycan recognition protein family
Prokaryotic-type class I peptide chain release factors
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Thiopeptide-type bacteriocin biosynthesis
Glyoxalase-like domain-containing protein
Solute-binding protein family 5 domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Anthranilate synthase component I N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Positions MEP for the nucleophilic attack
Plays an important role in substrate specificity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Cation-transporting P-type ATPase C-terminal
Gram-positive cocci surface proteins LPxTG
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cytochrome oxidase subunit II copper A binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Glycoside hydrolase family 42 N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
DNA primase/polymerase bifunctional N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Tetracyclin repressor-like C-terminal group 31
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Serine aminopeptidase S33 domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Could be important to modulate the pK values of the two catalytic cysteine residues
Cytochrome C biogenesis protein transmembrane
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphotransferase system enzyme I N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ABC transporter substrate-binding protein PnrA-like
Pyruvate dehydrogenase E1 component middle
Peptidase M43 pregnancy-associated plasma-A
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Large ribosomal subunit protein uL15/eL18
Beta-hexosaminidase bacterial type N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Sporulation transcription regulator WhiA N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
RlpA-like protein double-psi beta-barrel
Threonine/serine exporter-like N-terminal
Alpha-glycerophosphate oxidase C-terminal
Pseudouridine synthase I TruA alpha/beta
3-beta hydroxysteroid dehydrogenase/isomerase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
O-(5'-phospho-DNA)-tyrosine intermediate
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Molybdopterin cofactor biosynthesis C (MoaC)
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
vWA-MoxR associated protein middle region 0
Lactate utilization protein B C-terminal
Capsule synthesis protein CapA domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Schiff-base intermediate with substrate; via topaquinone
PhoD-like phosphatase metallophosphatase
Schiff-base intermediate with D-ribose 5-phosphate
Membrane insertase YidC/Oxa/ALB C-terminal
Ricin B lectin domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Interaction with polymerase core subunit RpoC
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Terminase large subunit gp17-like C-terminal
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Squalene cyclase C-terminal domain-containing protein
Phosphoribosylformylglycinamidine synthase linker
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Solute-binding protein family 3/N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Alginate lyase domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Transcription regulator AsnC/Lrp ligand binding
MmyB-like transcription regulator ligand binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NIF system FeS cluster assembly NifU N-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cytochrome b/b6 N-terminal region profile
Cysteine sulfenic acid (-SOH) intermediate
Bacterial type II secretion system protein E
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Adaptive response protein AidB N-terminal
Prepilin type IV endopeptidase peptidase
Could play a key role in the communication between the regulatory and the substrate sites
Proton acceptor; for glutaminase activity
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Alanyl-transfer RNA synthetases family profile
Large ribosomal subunit protein uL2 C-terminal
DnaJ homologue subfamily C member 28 conserved
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Glycoside hydrolase family 31 N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Cytochrome P460 domain-containing protein
Butirosin biosynthesis protein H N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Twin-arginine translocation signal domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
DNA replication/recombination mediator RecO N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Heme-copper oxidase subunit III family profile
Subtilisin inhibitor domain-containing protein
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Methylguanine DNA methyltransferase ribonuclease-like
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Cation-transporting P-type ATPase N-terminal
Involved in allosteric activation by GTP
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Putative regulatory protein FmdB Zinc ribbon
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Cytochrome b561 bacterial/Ni-hydrogenase
Probable subtilase-type protease inhibitor
Glucosamine/galactosamine-6-phosphate isomerase
Glycosyltransferase family 28 N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Damage-control phosphatase ARMT1-like metal-binding
N-acetylneuraminic acid synthase N-terminal
Sodium/calcium exchanger membrane region
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Aconitase A/isopropylmalate dehydratase small subunit swivel
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Allene oxide cyclase barrel-like domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein
Putative adhesin domain-containing protein
Lon proteolytic domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Diacylglycerol glucosyltransferase N-terminal
Phosphocysteine intermediate; for EIIB activity
Endoribonuclease L-PSP/chorismate mutase-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Small ribosomal subunit protein uS4 N-terminal
Tat pathway signal sequence domain protein
Cytochrome bc1 complex cytochrome c subunit
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Release factor glutamine methyltransferase N-terminal
Parallel beta-helix repeat-containing protein
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Styrene monooxygenase StyA putative substrate binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycosyl transferase family 28 C-terminal
non-reducing end alpha-L-arabinofuranosidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Branched-chain amino acid ABC transporter permease