Sodium/calcium exchanger membrane region
Major facilitator superfamily (MFS) profile
Large ribosomal subunit protein uL2 C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Flagellar hook-length control protein-like C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Plays an important role in discriminating NADH against NADPH
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glycosyltransferase subfamily 4-like N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Type II secretion system protein GspC N-terminal
TonB-dependent receptor-like beta-barrel
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Phosphocysteine intermediate; for EIIB activity
Mandelate racemase/muconate lactonizing enzyme C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Important for substrate binding and specificity
Penicillin-binding protein transpeptidase
Nucleoside-specific channel-forming protein Tsx
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Large ribosomal subunit protein uL6 alpha-beta
Tellurite resistance methyltransferase TehB-like
NIF system FeS cluster assembly NifU C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
NADH:ubiquinone oxidoreductase 30kDa subunit
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
O-(5'-phospho-DNA)-tyrosine intermediate
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
RND efflux pump membrane fusion protein barrel-sandwich
Transcription factor NikR nickel binding C-terminal
Phosphoethanolamine transferase N-terminal
Type II secretion system protein GspI C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Appears to be important in orienting the phosphate for catalysis
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Polysaccharide chain length determinant N-terminal
Interaction with polymerase core subunit RpoC
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Essential for degradation by Lon protease
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Calcium/calmodulin-dependent protein kinase II association-domain
Threonine/serine exporter-like N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Interacts with tRNA; defines subfamily-specific binding signature
D-galactose/methyl-galactoside binding periplasmic protein MglB
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Superoxide dismutase copper/zinc binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Membrane fusion protein biotin-lipoyl like
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Alpha-glycerophosphate oxidase C-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Outer membrane protein assembly factor BamD
Exonuclease VII large subunit C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Glucosamine/galactosamine-6-phosphate isomerase
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glycosyl transferase family 3 N-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polymerase/histidinol phosphatase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Penicillin-binding protein activator LpoB
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Tryptophan synthase beta chain-like PALP
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Plays an important role in substrate specificity
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Gfo/Idh/MocA-like oxidoreductase N-terminal
Gamma-glutamylcyclotransferase AIG2-like
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
RNA methyltransferase SpoU/TrmH type C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Neurotransmitter-gated ion-channel ligand-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Arginine decarboxylase C-terminal helical
Aconitase A/isopropylmalate dehydratase small subunit swivel
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Important for interaction with partner proteins
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Cysteine sulfenic acid (-SOH) intermediate
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
SUF system FeS cluster assembly SufBD N-terminal
Arabinogalactan endo-beta-1,4-galactanase
Resolvase/invertase-type recombinase catalytic
6-phosphogluconate dehydrogenase C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Cation-transporting P-type ATPase N-terminal
DnaJ homologue subfamily C member 28 conserved
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Peptidase S9 prolyl oligopeptidase catalytic
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Flagellar motor switch protein FliN-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Anthranilate synthase component I N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Bacterial transcription activator effector binding
Cob(I)alamin adenosyltransferase N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Translation elongation factor P/YeiP central
Pseudouridine synthase I TruA alpha/beta
Involved in allosteric activation by GTP
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Molybdopterin cofactor biosynthesis C (MoaC)
UDP N-acetylglucosamine O-acyltransferase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Pectate lyase superfamily protein domain-containing protein
Choloylglycine hydrolase/NAAA C-terminal
NIF system FeS cluster assembly NifU N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Dinitrogenase iron-molybdenum cofactor biosynthesis
Prokaryotic-type class I peptide chain release factors
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glycosyl hydrolase family 30 beta sandwich
Alpha-D-phosphohexomutase alpha/beta/alpha
Type II secretion system protein GspG C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Mannose-6-phosphate isomerase type II C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Membrane-bound lytic murein transglycosylase C
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Small ribosomal subunit protein uS4 N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Nitrite/Sulfite reductase ferredoxin-like
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Aspartate/homoserine dehydrogenase NAD-binding
Flagellar motor switch protein FliN N-terminal
Pyruvate dehydrogenase E1 component middle
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Could play a key role in the communication between the regulatory and the substrate sites
Spore coat protein U domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)
TonB C-terminal domain-containing protein
Glycine cleavage T-protein C-terminal barrel
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Chromosomal replication initiator protein DnaA
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
RNA binding; important for wobble base 34 recognition
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptide methionine sulphoxide reductase MsrA
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glycoside hydrolase family 13 N-terminal
Reversibly protonated during proton transport
Serine/threonine specific protein phosphatases
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Essential for prephenate dehydratase activity
Outer membrane protein assembly factor BamA
serine-type D-Ala-D-Ala carboxypeptidase
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Bacterial type II secretion system protein E
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Integral membrane protein YccS N-terminal
Outer-membrane lipoprotein Wza C-terminal
Transposase IS116/IS110/IS902 C-terminal
Large ribosomal subunit protein uL15/eL18
Thymidylate synthase/dCMP hydroxymethylase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein bL25 L25
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DNA polymerase III subunit delta C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Phosphotransferase system enzyme I N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
4'-phosphopantetheinyl transferase N-terminal