Heat-inducible transcription repressor HrcA C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Solute-binding protein family 3/N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Polysaccharide chain length determinant N-terminal
ABC-type glycine betaine transport system substrate-binding
Large ribosomal subunit protein uL6 alpha-beta
Ribosomal RNA adenine methylase transferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Glucose-methanol-choline oxidoreductase N-terminal
Major facilitator superfamily (MFS) profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Glycosyltransferase subfamily 4-like N-terminal
Resolvase/invertase-type recombinase catalytic
Schiff-base intermediate with substrate; via pyruvic acid
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
4'-phosphopantetheinyl transferase N-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Twin-arginine translocation signal domain-containing protein
Membrane fusion protein biotin-lipoyl like
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Inner membrane protein YgaP-like transmembrane
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Plays an important role in substrate specificity
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Tryptophan synthase beta chain-like PALP
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
RND efflux pump membrane fusion protein barrel-sandwich
Penicillin-binding protein transpeptidase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Saccharopine dehydrogenase-like C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Transposase IS116/IS110/IS902 C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Pyrroline-5-carboxylate reductase catalytic N-terminal
Nitrite/Sulfite reductase ferredoxin-like
L,D-transpeptidase catalytic domain-containing protein
Ionotropic glutamate receptor C-terminal
Carboxypeptidase regulatory-like domain-containing protein
Polymerase/histidinol phosphatase N-terminal
CagE TrbE VirB component of type IV transporter system central
Thiol:disulfide interchange protein DsbD N-terminal
Thiol:disulfide interchange protein DsbD N-terminal domain-containing protein
Flagellar basal body rod protein N-terminal
PHA accumulation regulator DNA-binding N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Endoribonuclease L-PSP/chorismate mutase-like
Aromatic amino acid beta-eliminating lyase/threonine aldolase
RNA polymerase sigma factor 70 region 1.1
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Probable periplasmic serine endoprotease DegP-like
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Type I restriction enzyme R protein N-terminal
RNA polymerase sigma factor 70 region 4 type 2
TonB C-terminal domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
NIF system FeS cluster assembly NifU N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Flagellar basal-body/hook protein C-terminal
6-phosphogluconate dehydrogenase C-terminal
Periplasmic binding protein domain-containing protein
Heme-copper oxidase subunit III family profile
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Mannose-6-phosphate isomerase type II C-terminal
General stress protein FMN-binding split barrel
Glycine cleavage T-protein C-terminal barrel
Bacterial type II secretion system protein E
Reversibly protonated during proton transport
Methylene-tetrahydrofolate reductase C-terminal
ATP-grasp fold succinyl-CoA synthetase-type
N-sulphoglucosamine sulphohydrolase C-terminal
Prokaryotic-type class I peptide chain release factors
Survival protein SurE-like phosphatase/nucleotidase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
UDP N-acetylglucosamine O-acyltransferase C-terminal
Type VI secretion system IcmF C-terminal
Pseudouridine synthase I TruA alpha/beta
Nitrogenase molybdenum-iron protein beta chain N-terminal
peptide-methionine (R)-S-oxide reductase
Electron transfer via tryptophanyl radical
NADH:ubiquinone oxidoreductase 30kDa subunit
Anaphase-promoting complex subunit 4-like WD40
Release factor glutamine methyltransferase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DNA topoisomerase I catalytic core eukaryotic-type
Ricin B lectin domain-containing protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Signal transduction histidine kinase HWE region
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Schiff-base intermediate with dihydroxyacetone-P
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cytochrome C biogenesis protein transmembrane
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Major facilitator superfamily associated
Cytochrome c oxidase subunit IV bacterial aa3 type
Transcription elongation factor GreA/GreB N-terminal
ABC transporter substrate-binding protein PnrA-like
Inosine/uridine-preferring nucleoside hydrolase
DNA mismatch repair proteins mutS family
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
Alanyl-transfer RNA synthetases family profile
NADH-rubredoxin oxidoreductase C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
RNA binding; important for wobble base 34 recognition
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
N-end rule aminoacyl transferase C-terminal
Flagellar motor switch protein FliN-like C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Acyl-CoA dehydrogenase N-terminal bacteria
Outer membrane protein assembly factor BamD
Peptidase M17 leucyl aminopeptidase N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Thiamin/hydroxymethyl pyrimidine-binding YkoF putative
Histidine phosphotransferase ChpT C-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
YMGG-like Gly-zipper domain-containing protein
Prepilin type IV endopeptidase peptidase
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Important for beta-aspartyl-AMP intermediate formation
CASTOR/POLLUX/SYM8 ion channel conserved
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glycosyl transferase family 3 N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
RNA 2-O ribose methyltransferase substrate binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Sodium/calcium exchanger membrane region
Ribose-phosphate pyrophosphokinase N-terminal
Surface antigen domain-containing protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
ABC-type transport auxiliary lipoprotein component
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Poly-beta-hydroxybutyrate polymerase N-terminal
Alpha-glycerophosphate oxidase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Chromosomal replication initiator protein DnaA
Large ribosomal subunit protein uL15/eL18
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Large ribosomal subunit protein uL2 C-terminal
Interaction with polymerase core subunit RpoC
Antitoxin Xre/MbcA/ParS-like toxin-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Peptidase S9 prolyl oligopeptidase catalytic
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Transglycosylase SLT domain-containing protein
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Outer membrane protein assembly factor BamA
Cytochrome b561 bacterial/Ni-hydrogenase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyrroline-5-carboxylate reductase dimerisation
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
O-(3'-phospho-DNA)-tyrosine intermediate
Essential for prephenate dehydratase activity
Glutamate synthase alpha subunit C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Phosphate starvation-inducible protein PsiF
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Polysaccharide biosynthesis protein C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Caspase family p20 domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
DNA replication/recombination mediator RecO N-terminal
Proline utilization A proline dehydrogenase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Anthranilate synthase component I N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polysaccharide biosynthesis protein CapD-like
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Gp5/Type VI secretion system Vgr protein OB-fold
Organic solvent tolerance-like N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Schiff-base intermediate with acetoacetate
Septum formation inhibitor MinC C-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Insecticide toxin TcdB middle/N-terminal
Insecticide toxin TcdB middle/N-terminal domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Spore coat protein U domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Invasion associated locus B family protein
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Cobaltochelatase subunit CobS N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Translation elongation factor P/YeiP central
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Putative auto-transporter adhesin head GIN
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Putative glycogen debranching enzyme N-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Transcription regulator AsnC/Lrp ligand binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Chromosomal replication initiator DnaA C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
S-adenosylmethionine-dependent methyltransferase
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19 domain-containing protein
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Flagellar hook-length control protein-like C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Small ribosomal subunit protein uS4 N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
TRAP C4-dicarboxylate transport system permease DctM subunit
Proton acceptor; for glutaminase activity
Membrane insertase YidC/Oxa/ALB C-terminal
Adaptive response protein AidB N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Required for zinc-mediated homotetramerization and catalytic activity
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphoribosylformylglycinamidine synthase linker
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Pilus formation protein N-terminal domain-containing protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NADH:ubiquinone oxidoreductase-like 20kDa subunit
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Methionyl-tRNA synthetase anticodon-binding
Thiamin pyrophosphokinase thiamin-binding
Peptide methionine sulphoxide reductase MsrA
Molybdopterin cofactor biosynthesis C (MoaC)
Beta-lactamase hydrolase-like protein phosphatase-like
Phosphatidylglycerol lysyltransferase C-terminal
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
ABC transporter substrate-binding protein
Pyrimidine nucleoside phosphorylase C-terminal
Exonuclease VII large subunit C-terminal
Cob(I)alamin adenosyltransferase N-terminal