DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Leucine-binding protein domain-containing protein
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
ABC-type glycine betaine transport system substrate-binding
Endolytic peptidoglycan transglycosylase RlpA
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Serine/threonine specific protein phosphatases
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cytochrome b561 bacterial/Ni-hydrogenase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
UDP N-acetylglucosamine O-acyltransferase C-terminal
Outer membrane protein assembly factor BamC
Bacterial type II secretion system protein E
Tryptophan synthase beta chain-like PALP
Major facilitator superfamily (MFS) profile
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Could be important to modulate the pK values of the two catalytic cysteine residues
Prokaryotic-type class I peptide chain release factors
Survival protein SurE-like phosphatase/nucleotidase
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Inner membrane protein YgaP-like transmembrane
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Soluble ligand binding domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Zn-dependent metallo-hydrolase RNA specificity
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Alpha-D-phosphohexomutase alpha/beta/alpha
Interaction with polymerase core subunit RpoC
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Translation elongation factor P/YeiP central
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Thiosulphate:quinone oxidoreductase small subunit DoxA
Phosphotransferase system enzyme I N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Penicillin-binding protein transpeptidase
PEP-CTERM protein-sorting domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Important for beta-aspartyl-AMP intermediate formation
Alanyl-transfer RNA synthetases family profile
Probable transposase IS891/IS1136/IS1341
RNA 2-O ribose methyltransferase substrate binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyruvate phosphate dikinase AMP/ATP-binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Flagellar assembly protein FliH/Type III secretion system HrpE
Large ribosomal subunit protein uL15/eL18
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interchain (with Cys-213); in linked form
Interchain (with Cys-54); in linked form
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Glycine cleavage T-protein C-terminal barrel
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Quercetin 2,3-dioxygenase C-terminal cupin
Solute-binding protein family 3/N-terminal
Solute-binding protein family 5 domain-containing protein
Outer membrane lipoprotein carrier protein LolA
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
DNA replication/recombination mediator RecO N-terminal
High potential iron-sulfur proteins family profile
Plays an important role in discriminating NADH against NADPH
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
RNA polymerase sigma factor 70 region 4 type 2
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Transcription regulator AsnC/Lrp ligand binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Arginine decarboxylase C-terminal helical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Polypeptide-transport-associated ShlB-type
Glucose-methanol-choline oxidoreductase N-terminal
Heme-copper oxidase subunit III family profile
Positions MEP for the nucleophilic attack
Plays an important role in substrate specificity
NIF system FeS cluster assembly NifU N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
NfeD-like C-terminal domain-containing protein
PsbP C-terminal domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Thiol:disulfide interchange protein DsbD
Pseudouridine synthase I TruA alpha/beta
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Molybdopterin cofactor biosynthesis C (MoaC)
Resolvase/invertase-type recombinase catalytic
Electron transfer via tryptophanyl radical
Polymerase/histidinol phosphatase N-terminal
Transposase IS116/IS110/IS902 C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Lipoprotein SmpA/OmlA domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Iron ABC transporter substrate-binding protein
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
EfeO-type cupredoxin-like domain-containing protein
TRAP C4-dicarboxylate transport system permease DctM subunit
Outer membrane protein beta-barrel domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RNA binding; important for wobble base 34 recognition
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Antitoxin Xre/MbcA/ParS-like toxin-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
NADH:ubiquinone oxidoreductase 30kDa subunit
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycine zipper 2TM domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA mismatch repair proteins mutS family
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Butirosin biosynthesis protein H N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
PilC beta-propeller domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Flagellar hook-length control protein-like C-terminal
Glycoside hydrolase family 31 N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
DNA polymerase III delta subunit C-terminal
Ubiquinol-cytochrome c reductase iron-sulfur subunit
P-type conjugative transfer protein VirB9
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Chromosomal replication initiator DnaA C-terminal
Glycoside hydrolase family 57 N-terminal
Important for substrate binding and specificity
Phage tail collar domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Organic solvent tolerance-like N-terminal
S-adenosylmethionine-dependent methyltransferase
Alpha-glycerophosphate oxidase C-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
ABC transporter substrate-binding protein PnrA-like
Restriction endonuclease type I HsdR N-terminal
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Small ribosomal subunit protein uS4 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Bacteriophage lambda Replication protein O N-terminal
Polysaccharide biosynthesis protein C-terminal
ABC transporter substrate-binding protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Putative regulatory protein FmdB Zinc ribbon
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Reversibly protonated during proton transport
HPr(Ser) kinase/phosphorylase N-terminal
DNA polymerase III subunit delta C-terminal
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Essential for prephenate dehydratase activity
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Gamma-butyrobetaine hydroxylase-like N-terminal
6-phosphogluconate dehydrogenase C-terminal
Glycosyl transferase family 3 N-terminal
Outer membrane protein assembly factor BamD
Required for zinc-mediated homotetramerization and catalytic activity
Carboxypeptidase regulatory-like domain-containing protein
Transglycosylase SLT domain-containing protein
N6 adenine-specific DNA methyltransferase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Signal transduction histidine kinase internal region
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Sodium/calcium exchanger membrane region
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Exonuclease VII large subunit C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
CagE TrbE VirB component of type IV transporter system central
Beta-lactamase hydrolase-like protein phosphatase-like
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Histidine-specific methyltransferase SAM-dependent
Glucosamine/galactosamine-6-phosphate isomerase
Type II secretion system protein GspE N-terminal
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Sugar ABC transporter substrate-binding protein
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Mannose-6-phosphate isomerase type II C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Plastocyanin-like domain-containing protein
Integral membrane protein YccS N-terminal
Lytic transglycosylase superhelical linker
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Outer membrane protein assembly factor BamE
Toxin co-regulated pilus biosynthesis protein Q C-terminal
DNA-directed DNA polymerase family A palm
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Proton acceptor; for glutaminase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Outer membrane protein assembly factor BamB
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Aromatic hydrocarbon degradation protein
ABC-type uncharacterised transport system
Ribulose bisphosphate carboxylase small subunit
Heat-inducible transcription repressor HrcA C-terminal
Type I restriction modification DNA specificity
Anthranilate synthase component I N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Ribosomal RNA adenine methylase transferase N-terminal
Type 4 fimbrial biogenesis protein PilX N-terminal
Type IV secretion system coupling protein TraD DNA-binding
TonB-dependent receptor-like beta-barrel