Major facilitator superfamily (MFS) profile
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Polysaccharide biosynthesis protein C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Bacterial bifunctional deaminase-reductase C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:ubiquinone oxidoreductase 30kDa subunit
Solute-binding protein family 3/N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Histidine phosphotransferase ChpT C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Mannose-6-phosphate isomerase type II C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Transposase IS116/IS110/IS902 C-terminal
Reversibly protonated during proton transport
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
ABC transporter substrate-binding protein PnrA-like
Major facilitator superfamily associated
TRAP C4-dicarboxylate transport system permease DctM subunit
Plays an important role in substrate specificity
Yop protein translocation protein D periplasmic
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Bacterial type II secretion system protein E
Dinitrogenase iron-molybdenum cofactor biosynthesis
ABC-type glycine betaine transport system substrate-binding
Chromosomal replication initiator protein DnaA
Flagellar motor switch protein FliN-like C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cytochrome b561 bacterial/Ni-hydrogenase
Involved in allosteric activation by GTP
Phosphatidic acid phosphatase type 2/haloperoxidase
Methylene-tetrahydrofolate reductase C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ionotropic glutamate receptor C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Cobaltochelatase subunit CobS N-terminal
Penicillin-binding protein transpeptidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Alpha/beta hydrolase domain-containing protein
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
L,D-transpeptidase catalytic domain-containing protein
Antitoxin Xre/MbcA/ParS-like toxin-binding
Interaction with polymerase core subunit RpoC
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Small ribosomal subunit protein uS4 N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
RNA polymerase sigma factor 70 region 4 type 2
Phosphoadenosine phosphosulphate reductase
Thymidylate synthase/dCMP hydroxymethylase
Poly-beta-hydroxybutyrate polymerase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Essential for prephenate dehydratase activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Carbamoyl-phosphate synthase small subunit N-terminal
Phosphoribosylformylglycinamidine synthase linker
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Tryptophan synthase beta chain-like PALP
Large ribosomal subunit protein uL30-like ferredoxin-like fold
5-glutamyl coenzyme A thioester intermediate
Activator of Hsp90 ATPase homologue 1-like C-terminal
Resolvase/invertase-type recombinase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
Release factor glutamine methyltransferase N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Glucosamine/galactosamine-6-phosphate isomerase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Tat pathway signal sequence domain protein
Thiamin pyrophosphokinase thiamin-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
L-seryl-tRNA selenium transferase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Heme-copper oxidase subunit III family profile
Important for interaction with partner proteins
PHA accumulation regulator DNA-binding N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Cytochrome c-type biogenesis protein CcmF C-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Chromosomal replication initiator DnaA C-terminal
Glycoside hydrolase family 42 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Pseudouridine synthase I TruA alpha/beta
Sodium symporter small subunit predicted
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Beta-lactamase hydrolase-like protein phosphatase-like
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Ribosomal RNA adenine methylase transferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Could be important to modulate the pK values of the two catalytic cysteine residues
K(+)-insensitive pyrophosphate-energized proton pump
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
YbaK/aminoacyl-tRNA synthetase-associated
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Flagellar hook-length control protein-like C-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Probable periplasmic serine endoprotease DegP-like
Glucose-methanol-choline oxidoreductase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Signal transduction histidine kinase HWE region
Prokaryotic-type class I peptide chain release factors
RNA binding; important for wobble base 34 recognition
Prepilin type IV endopeptidase peptidase
Translation elongation factor P/YeiP central
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19
Glycine cleavage T-protein C-terminal barrel
S-adenosylmethionine-dependent methyltransferase
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Large ribosomal subunit protein uL15/eL18
Periplasmic copper-binding protein NosD beta helix
Periplasmic copper-binding protein NosD beta helix domain-containing protein
Sodium/calcium exchanger membrane region
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Outer membrane protein assembly factor BamD
Transcription regulator AsnC/Lrp ligand binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Nitrogenase molybdenum-iron protein beta chain N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein uL6 alpha-beta
Anaphase-promoting complex subunit 4-like WD40
DNA mismatch repair proteins mutS family
Cytochrome c oxidase subunit IV bacterial aa3 type
Cytochrome C biogenesis protein transmembrane
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Acetyl-CoA dehydrogenase-like C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Heat-inducible transcription repressor HrcA C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
RNA 2-O ribose methyltransferase substrate binding