Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Transposase IS204/IS1001/IS1096/IS1165 DDE
Endoribonuclease L-PSP/chorismate mutase-like
Resolvase/invertase-type recombinase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
Glycosyltransferase subfamily 4-like N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
NIF system FeS cluster assembly NifU N-terminal
Peptide methionine sulphoxide reductase MsrA
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Solute-binding protein family 3/N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Major facilitator superfamily (MFS) profile
Exonuclease VII large subunit C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Peptidase M1 membrane alanine aminopeptidase
Phosphomannose isomerase type I catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein uL2 C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glucose-methanol-choline oxidoreductase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cytochrome b561 bacterial/Ni-hydrogenase
Ribosomal RNA adenine methylase transferase N-terminal
Heme-copper oxidase subunit III family profile
Thymidylate synthase/dCMP hydroxymethylase
RNA 2-O ribose methyltransferase substrate binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Transcription regulator AsnC/Lrp ligand binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Polysaccharide chain length determinant N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Reversibly protonated during proton transport
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Helix-hairpin-helix DNA-binding motif class 1
Methionyl-tRNA synthetase anticodon-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Schiff-base intermediate with acetaldehyde
Cell envelope-related transcriptional attenuator
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Positions MEP for the nucleophilic attack
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Release factor glutamine methyltransferase N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
N6 adenine-specific DNA methyltransferase N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Could play a key role in the communication between the regulatory and the substrate sites
Heat-inducible transcription repressor HrcA C-terminal
Polymerase/histidinol phosphatase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
ABC-type glycine betaine transport system substrate-binding
Cytochrome C biogenesis protein transmembrane
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Shikimate dehydrogenase substrate binding N-terminal
Prokaryotic-type class I peptide chain release factors
General stress protein FMN-binding split barrel
Tryptophan synthase beta chain-like PALP
Alanyl-transfer RNA synthetases family profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Sporulation transcription regulator WhiA N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Gly-cisPro motif, important for rejection of L-amino acids
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Membrane fusion protein biotin-lipoyl like
Type I restriction modification DNA specificity
Dinitrogenase iron-molybdenum cofactor biosynthesis
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
YbaK/aminoacyl-tRNA synthetase-associated
Pyruvate dehydrogenase E1 component middle
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Pyrimidine nucleoside phosphorylase C-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL15/eL18
Transglutaminase-like domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Interaction with polymerase core subunit RpoC
Phosphotyrosine protein phosphatase I domain-containing protein
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cysteine sulfenic acid (-SOH) intermediate
Mandelate racemase/muconate lactonizing enzyme C-terminal
Restriction system protein Mrr-like N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Cation-transporting P-type ATPase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Anthranilate synthase component I N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Putative regulatory protein FmdB Zinc ribbon
Polysaccharide biosynthesis protein C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pseudouridine synthase I TruA alpha/beta
ABC-type glycine betaine transport system substrate-binding domain-containing protein
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Probable endolytic peptidoglycan transglycosylase RlpA
Small ribosomal subunit protein uS4 N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Transition state stabilizer; via amide nitrogen
Pyruvate phosphate dikinase AMP/ATP-binding
6-phosphogluconate dehydrogenase C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Phosphoribosylformylglycinamidine synthase linker
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
DNA-directed DNA polymerase family A palm
SUF system FeS cluster assembly SufBD N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Glycosyl transferase family 3 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-97)
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Plays an important role in substrate specificity
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Translation elongation factor P/YeiP central
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Phosphocysteine intermediate; for EIIB activity
DNA replication/recombination mediator RecO N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Peptidase S9 prolyl oligopeptidase catalytic
tRNA pseudouridylate synthase B C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Bacterial type II secretion system protein E
Proton acceptor; for glutaminase activity
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Phosphotransferase system enzyme I N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Membrane insertase YidC/Oxa/ALB C-terminal
RlpA-like protein double-psi beta-barrel
NADH:ubiquinone oxidoreductase 30kDa subunit
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Essential for prephenate dehydratase activity
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Bacterial transcription activator effector binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose