Aminoacyl-transfer RNA synthetases class-II family profile
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Biopterin-dependent aromatic amino acid hydroxylase family profile
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
TonB-dependent receptor-like beta-barrel
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Outer membrane protein beta-barrel domain-containing protein
Major facilitator superfamily (MFS) profile
Ribose-phosphate pyrophosphokinase N-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
3-keto-disaccharide hydrolase domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alpha-glycerophosphate oxidase C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Malonate/sodium symporter MadM subunit N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
TonB-dependent receptor plug domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Gliding motility-associated protein GldM C-terminal
Gliding motility-associated protein GldM N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Bacterial surface antigen (D15) domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
RND efflux pump membrane fusion protein barrel-sandwich
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Carboxypeptidase-like regulatory domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Important for beta-aspartyl-AMP intermediate formation
Peptidase M1 membrane alanine aminopeptidase
Lipocalin-like domain-containing protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Alpha-L-glutamate ligase-related protein ATP-grasp
Polysaccharide chain length determinant N-terminal
Type IX secretion system protein PorV domain-containing protein
Prokaryotic-type class I peptide chain release factors
Survival protein SurE-like phosphatase/nucleotidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Nitrite/Sulfite reductase ferredoxin-like
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribosomal RNA adenine methylase transferase N-terminal
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Type I restriction enzyme R protein N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Glucosamine/galactosamine-6-phosphate isomerase
Release factor glutamine methyltransferase N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Alanyl-transfer RNA synthetases family profile
Signal transduction histidine kinase internal region
Cysteine sulfenic acid (-SOH) intermediate
RNA polymerase sigma factor 70 region 4 type 2
NAD(P) transhydrogenase alpha subunit C-terminal
Type IX secretion system membrane protein PorP/SprF
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Important for interaction with partner proteins
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Pseudouridine synthase I TruA alpha/beta
Carboxypeptidase regulatory-like domain-containing protein
UDP N-acetylglucosamine O-acyltransferase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Gliding motility-associated C-terminal domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Exonuclease VII large subunit C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
RNA 2-O ribose methyltransferase substrate binding
Anthranilate synthase component I N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Schiff-base intermediate with acetaldehyde
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
AMP-activated protein kinase glycogen-binding
Schiff-base intermediate with substrate; via pyruvic acid
N-sulphoglucosamine sulphohydrolase C-terminal
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Penicillin-binding protein transpeptidase
Putative adhesin domain-containing protein
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Putative oxidoreductase/dehydrogenase Rossmann-like
Large ribosomal subunit protein uL6 alpha-beta
SUF system FeS cluster assembly SufBD N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Tryptophan synthase beta chain-like PALP
Alpha-D-phosphohexomutase alpha/beta/alpha
Alpha-L-rhamnosidase six-hairpin glycosidase
Non-canonical purine NTP phosphatase/PRRC1
ATP synthase F1 complex delta/epsilon subunit N-terminal
Type I restriction modification DNA specificity
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Beta-hexosaminidase bacterial type N-terminal
Solute-binding protein family 3/N-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
AB hydrolase-1 domain-containing protein
Lysidine-tRNA(Ile) synthetase C-terminal
DNA mismatch repair proteins mutS family
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal domain-containing protein
Positions MEP for the nucleophilic attack
Large ribosomal subunit protein uL15/eL18
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Inner membrane protein YgaP-like transmembrane
Iron dependent repressor metal binding and dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
RNA binding; important for wobble base 34 recognition
DNA-directed DNA polymerase family A palm
Helix-hairpin-helix DNA-binding motif class 1
Leucine-binding protein domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Polysaccharide biosynthesis protein C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Membrane fusion protein biotin-lipoyl like
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
ssDNA thymidine ADP-ribosyltransferase DarT
Organic solvent tolerance-like N-terminal
Thymidylate synthase/dCMP hydroxymethylase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Glycoside hydrolase family 13 N-terminal
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Resolvase/invertase-type recombinase catalytic
Peptide methionine sulphoxide reductase MsrA
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Large ribosomal subunit protein uL2 C-terminal
Glycoside hydrolase family 31 N-terminal
Glycine cleavage T-protein C-terminal barrel
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Fibrobacter succinogenes major paralogous
Tetrahydrodipicolinate-N-succinyltransferase chain A
Proton acceptor; for glutaminase activity
Secretion system C-terminal sorting domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cation-transporting P-type ATPase N-terminal
Electron transfer via tryptophanyl radical
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Gly-cisPro motif, important for rejection of L-amino acids
O-(5'-phospho-DNA)-tyrosine intermediate
O-(3'-phospho-DNA)-tyrosine intermediate
Type 1 periplasmic binding fold superfamily protein
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
N6 adenine-specific DNA methyltransferase N-terminal
Glycoside hydrolase family 57 N-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Reversibly protonated during proton transport
Alpha-(1,3)-fucosyltransferase FucT N-terminal
Sortilin N-terminal domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP
Glycosyl transferase family 3 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Plays an important role in substrate specificity
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Bacterial bifunctional deaminase-reductase C-terminal
Lipoprotein YgdI/YgdR-like SH3-like domain-containing protein
Guanylate cyclase domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Polysaccharide biosynthesis protein CapD-like
6-phosphogluconate dehydrogenase C-terminal
NIF system FeS cluster assembly NifU C-terminal
Ysc84 actin-binding domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein
Important for substrate specificity; cannot use PPi as phosphoryl donor
Sodium symporter small subunit predicted
Neutral/alkaline non-lysosomal ceramidase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycosyl-hydrolase 97 C-terminal oligomerisation
Beta-lactamase-related domain-containing protein
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Heme-copper oxidase subunit III family profile
DNA replication/recombination mediator RecO N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-103)
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Putative auto-transporter adhesin head GIN
Transition state stabilizer; via amide nitrogen
TRAP C4-dicarboxylate transport system permease DctM subunit
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Sodium/calcium exchanger membrane region
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Trigger factor ribosome-binding bacterial
Activator of Hsp90 ATPase homologue 1-like C-terminal
ABC-type uncharacterised transport system
SGNH hydrolase-type esterase domain-containing protein
Urease accessory protein UreH-like transmembrane
Inward rectifier potassium channel C-terminal
Saccharopine dehydrogenase-like C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
ATP-grasp fold succinyl-CoA synthetase-type
Fibronectin type-III domain-containing protein
Translation elongation factor P/YeiP central
Cytochrome c-type biogenesis protein CcmF C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding