Aminoacyl-transfer RNA synthetases class-II family profile
Polymerase/histidinol phosphatase N-terminal
Polysaccharide biosynthesis protein C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Metallo-beta-lactamase domain-containing protein
Anthranilate synthase component I N-terminal
DNA-directed DNA polymerase family A palm
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Ribose-phosphate pyrophosphokinase N-terminal
Toxin-antitoxin system YwqK family antitoxin
Flavocytochrome c sulphide dehydrogenase flavin-binding
Cytochrome c-type biogenesis protein CcmF C-terminal
TonB-dependent receptor-like beta-barrel
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Positions MEP for the nucleophilic attack
Bacterial type II secretion system protein E
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Heme-copper oxidase subunit III family profile
Autotransporter domain-containing protein
Proton acceptor; for glutaminase activity
Glycine zipper 2TM domain-containing protein
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Important for beta-aspartyl-AMP intermediate formation
Urease accessory protein UreH-like transmembrane
Pyruvate phosphate dikinase AMP/ATP-binding
Solute-binding protein family 3/N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Electron transfer via tryptophanyl radical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA-directed RNA polymerase RpoA/D/Rpb3-type
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Ribosomal RNA adenine methylase transferase N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Glycine cleavage T-protein C-terminal barrel
Penicillin-binding protein transpeptidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Important for substrate binding and specificity
Ribulose bisphosphate carboxylase small subunit
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Outer membrane lipoprotein-sorting protein
Large ribosomal subunit protein uL2 C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Chromosomal replication initiator protein DnaA
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Tryptophan synthase beta chain-like PALP
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Antitoxin Xre/MbcA/ParS-like toxin-binding
Interaction with polymerase core subunit RpoC
Disulphide bond isomerase DsbC/G N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Peptide methionine sulphoxide reductase MsrA
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Alanyl-transfer RNA synthetases family profile
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
S-adenosyl-L-homocysteine hydrolase NAD binding
Small ribosomal subunit protein uS4 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
UDP N-acetylglucosamine O-acyltransferase C-terminal
Large ribosomal subunit protein uL15/eL18
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Doubled CXXCH motif domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
DNA polymerase III subunit delta C-terminal
Plays an important role in substrate specificity
Chromosomal replication initiator DnaA C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Prokaryotic-type class I peptide chain release factors
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Interacts with tRNA; defines subfamily-specific binding signature
Important for interaction with partner proteins
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein uL6 alpha-beta
Transport-associated and nodulation domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Pyruvate dehydrogenase E1 component middle
Pseudouridine synthase I TruA alpha/beta
Gamma-glutamylcyclotransferase AIG2-like
DNA replication/recombination mediator RecO N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Shikimate dehydrogenase substrate binding N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Aconitase A/isopropylmalate dehydratase small subunit swivel
Molybdopterin cofactor biosynthesis C (MoaC)
NIF system FeS cluster assembly NifU N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Major facilitator superfamily (MFS) profile
RNA 2-O ribose methyltransferase substrate binding
O-(3'-phospho-DNA)-tyrosine intermediate
NADH:ubiquinone oxidoreductase 30kDa subunit
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Resolvase/invertase-type recombinase catalytic
Exonuclease VII large subunit C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Mannose-6-phosphate isomerase type II C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
RNA binding; important for wobble base 34 recognition
Polysaccharide biosynthesis protein CapD-like
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Type II secretion system protein GspE N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Glycosyl transferase family 3 N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Survival protein SurE-like phosphatase/nucleotidase
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Inner membrane protein YgaP-like transmembrane
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Gamma-butyrobetaine hydroxylase-like N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
ATP synthase F1 complex delta/epsilon subunit N-terminal
Essential for prephenate dehydratase activity
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Outer-membrane lipoprotein carrier protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Sodium symporter small subunit predicted
Lysidine-tRNA(Ile) synthetase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Transglycosylase SLT domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Helix-hairpin-helix DNA-binding motif class 1
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Prepilin type IV endopeptidase peptidase
Membrane fusion protein biotin-lipoyl like domain-containing protein
Translation elongation factor P/YeiP central
Aromatic amino acid beta-eliminating lyase/threonine aldolase
ABC transporter substrate-binding protein
Membrane insertase YidC/Oxa/ALB C-terminal