S-adenosyl-L-homocysteine hydrolase NAD binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
ABC transporter substrate-binding protein PnrA-like
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
ABC transporter substrate-binding protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Aminoacyl-transfer RNA synthetases class-II family profile
Could play a key role in the communication between the regulatory and the substrate sites
Phosphotransferase system enzyme I N-terminal
Plays an important role in substrate specificity
Glycosyl hydrolase-like 10 domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Major facilitator superfamily (MFS) profile
Type I restriction modification DNA specificity
6-phosphogluconate dehydrogenase C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Sporulation transcription regulator WhiA N-terminal
DNA mismatch repair proteins mutS family
Glycosyl hydrolase family 30 beta sandwich
Molybdenum ABC transporter substrate-binding protein
Flagellar basal body rod protein N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Septum formation inhibitor MinC C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Tryptophan synthase beta chain-like PALP
Glycosyltransferase subfamily 4-like N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Copper amine oxidase-like N-terminal domain-containing protein
Sporulation stage IV protein A C-terminal
Flagellar Assembly Protein A N-terminal region
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Signal recognition particle SRP54 helical bundle
Transposase IS116/IS110/IS902 C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Ribonucleotide reductase large subunit C-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
Bacterial bifunctional deaminase-reductase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Transcription regulator AsnC/Lrp ligand binding
Important for interaction with partner proteins
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Schiff-base intermediate with dihydroxyacetone-P
Phosphomannose isomerase type I catalytic
Glycoside hydrolase family 31 N-terminal
Lipoprotein LpqB beta-propeller domain-containing protein
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
N6 adenine-specific DNA methyltransferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Resolvase/invertase-type recombinase catalytic
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Cell envelope-related transcriptional attenuator
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Nitrogenase molybdenum-iron protein beta chain N-terminal
Flagellar basal-body/hook protein C-terminal
Prepilin type IV endopeptidase peptidase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycosyl transferase family 3 N-terminal
Methionyl-tRNA synthetase anticodon-binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
RNA polymerase sigma factor 70 region 4 type 2
Pseudouridine synthase I TruA alpha/beta
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL6 alpha-beta
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Nitrite/Sulfite reductase ferredoxin-like
Exonuclease VII large subunit C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Signal transduction histidine kinase dimerisation/phosphoacceptor
ATP synthase F1 complex delta/epsilon subunit N-terminal
Schiff-base intermediate with acetaldehyde
Glycoside hydrolase family 42 N-terminal
Saccharopine dehydrogenase-like C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
S-adenosylmethionine-dependent methyltransferase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL15/eL18
Alanyl-transfer RNA synthetases family profile
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Phosphatidic acid phosphatase type 2/haloperoxidase
RNA binding; important for wobble base 34 recognition
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Zinc ABC transporter substrate-binding protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
YbaK/aminoacyl-tRNA synthetase-associated
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Membrane insertase YidC/Oxa/ALB C-terminal
Sortilin N-terminal domain-containing protein
Phosphocysteine intermediate; for EIIB activity
SMODS-associated and fused to various effectors
Flagellar motor switch protein FliN-like C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Essential for prephenate dehydratase activity
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Probable transposase IS891/IS1136/IS1341
Putative amidase domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Cysteine sulfenic acid (-SOH) intermediate
Helix-hairpin-helix DNA-binding motif class 1
ssDNA thymidine ADP-ribosyltransferase DarT
Small ribosomal subunit protein uS4 N-terminal
DNA replication/recombination mediator RecO N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Lysidine-tRNA(Ile) synthetase C-terminal
Translation elongation factor P/YeiP central
ABC-type glycine betaine transport system substrate-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Bacterial transcription activator effector binding
Mannose-6-phosphate isomerase type II C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
UDP-glucose/GDP-mannose dehydrogenase C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Na+-translocating membrane potential-generating system MpsC
Flagellar assembly protein FliH/Type III secretion system HrpE
RNA 2-O ribose methyltransferase substrate binding
Bacterial type II secretion system protein E
Type IV methyl-directed restriction enzyme EcoKMcrB subunit DNA-binding
Diacylglycerol glucosyltransferase N-terminal
Integron-associated effector binding protein
Protein O-mannosyl-transferase C-terminal four TM
dolichyl-phosphate-mannose--protein mannosyltransferase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Ribonucleotide reductase large subunit N-terminal
General stress protein FMN-binding split barrel
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cytochrome C biogenesis protein transmembrane
Siroheme decarboxylase AsnC-like ligand binding
SsuA/THI5-like domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Transcriptional regulator SgrR N-terminal HTH
Magnesium transporter MgtE intracellular
6-hydroxymethylpterin diphosphokinase MptE-like
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Peptidase M1 membrane alanine aminopeptidase
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Molybdopterin cofactor biosynthesis C (MoaC)
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Polymerase/histidinol phosphatase N-terminal
Fe/B12 periplasmic-binding domain-containing protein
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Schiff-base intermediate with substrate; via pyruvic acid
Polysaccharide biosynthesis protein CapD-like
Pyrimidine nucleoside phosphorylase C-terminal
Putative host cell surface-exposed lipoprotein Ltp-like HTH region
N-sulphoglucosamine sulphohydrolase C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Chromosomal replication initiator DnaA C-terminal
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polysaccharide biosynthesis protein C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Reversibly protonated during proton transport
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ferrous iron transport protein B C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Penicillin-binding protein transpeptidase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
NIF system FeS cluster assembly NifU C-terminal
BREX system Lon protease-like BrxL N-terminal
Protein-PII uridylyltransferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Sodium/calcium exchanger membrane region
Cation-transporting P-type ATPase N-terminal
Thiamin pyrophosphokinase thiamin-binding
Involved in allosteric activation by GTP
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Anthranilate synthase component I N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Major facilitator superfamily associated
DnaJ homologue subfamily C member 28 conserved
Important for autoinhibition of adenylyltransferase activity
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Putative aromatic acid exporter C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Polysaccharide chain length determinant N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Glucose-methanol-choline oxidoreductase C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Important for beta-aspartyl-AMP intermediate formation
Glycine cleavage T-protein C-terminal barrel
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Sporulation stage II protein D amidase enhancer LytB N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Dipicolinate synthase subunit A N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Phosphoribosylformylglycinamidine synthase linker
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Positions MEP for the nucleophilic attack
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Inhibitor of growth protein N-terminal histone-binding domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
Peptidase C-terminal archaeal/bacterial domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
Heme-copper oxidase subunit III family profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
HicB-like antitoxin of toxin-antitoxin system
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Microcin J25-processing protein McjB C-terminal
Spore germination GerAC-like C-terminal domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Gamma-glutamylcyclotransferase AIG2-like
DNA-directed DNA polymerase family A palm
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Interaction with polymerase core subunit RpoC