TRAP C4-dicarboxylate transport system permease DctM subunit
Pyruvate phosphate dikinase AMP/ATP-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tryptophan synthase beta chain-like PALP
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein uL2 C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Bacterial type II secretion system protein E
Sodium/calcium exchanger membrane region
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Glycine cleavage T-protein C-terminal barrel
Major facilitator superfamily (MFS) profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Solute-binding protein family 5 domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Heme-copper oxidase subunit III family profile
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cytochrome c-type biogenesis protein CcmF C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Involved in allosteric activation by GTP
TonB-dependent receptor-like beta-barrel
TonB C-terminal domain-containing protein
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Gfo/Idh/MocA-like oxidoreductase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Translation elongation factor P/YeiP central
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Poly-beta-hydroxybutyrate polymerase N-terminal
Transcription regulator AsnC/Lrp ligand binding
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA-directed DNA polymerase family A palm
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glycoside hydrolase family 31 N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Aminoacyl-transfer RNA synthetases class-II family profile
Glucose-methanol-choline oxidoreductase N-terminal
Proton acceptor; for glutaminase activity
Mandelate racemase/muconate lactonizing enzyme C-terminal
Small ribosomal subunit protein uS4 N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Important for interaction with partner proteins
Alanyl-transfer RNA synthetases family profile
Histidine phosphotransferase ChpT C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
ABC transporter substrate-binding protein PnrA-like
Cation-transporting P-type ATPase N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Cytochrome C biogenesis protein transmembrane
RNA polymerase sigma factor 70 region 4 type 2
Signal transduction histidine kinase HWE region
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Molybdopterin cofactor biosynthesis C (MoaC)
Type I restriction modification DNA specificity
Pyridine nucleotide-disulphide oxidoreductase dimerisation
C4-dicarboxylate ABC transporter substrate-binding protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
SsuA/THI5-like domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Saccharopine dehydrogenase-like C-terminal
Bacterial transcription activator effector binding
Cytochrome b561 bacterial/Ni-hydrogenase
Bacterial bifunctional deaminase-reductase C-terminal
CDP-alcohol phosphatidyltransferase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
L,D-transpeptidase catalytic domain-containing protein
YbaK/aminoacyl-tRNA synthetase-associated
Polysaccharide biosynthesis protein C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pseudouridine synthase I TruA alpha/beta
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Sodium symporter small subunit predicted
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Inner membrane protein YgaP-like transmembrane
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Peptide methionine sulphoxide reductase MsrA
NIF system FeS cluster assembly NifU N-terminal
Reversibly protonated during proton transport
RNA 2-O ribose methyltransferase substrate binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Lipocalin-like domain-containing protein
N,N-dimethylformamidase beta subunit-like C-terminal
Transposase IS116/IS110/IS902 C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Solute-binding protein family 3/N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phenol hydroxylase C-terminal dimerisation
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Oxidoreductase molybdopterin-binding domain-containing protein
Prokaryotic-type class I peptide chain release factors
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
O-(3'-phospho-DNA)-tyrosine intermediate
Endoribonuclease L-PSP/chorismate mutase-like
Phosphoadenosine phosphosulphate reductase
Abortive infection protein-like C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
HicB-like antitoxin of toxin-antitoxin system
Polysaccharide chain length determinant N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Aromatic amino acid beta-eliminating lyase/threonine aldolase
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
PHA accumulation regulator DNA-binding N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Penicillin-binding protein transpeptidase
Leucine-binding protein domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Prepilin type IV endopeptidase peptidase
Aconitase A/isopropylmalate dehydratase small subunit swivel
S-adenosyl-L-homocysteine hydrolase NAD binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Resolvase/invertase-type recombinase catalytic
Interaction with polymerase core subunit RpoC
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Heat-inducible transcription repressor HrcA C-terminal
Essential for prephenate dehydratase activity
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cell wall hydrolase SleB domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Carbamoyl-phosphate synthase small subunit N-terminal
Type I restriction enzyme R protein N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Transglycosylase SLT domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Phosphatidic acid phosphatase type 2/haloperoxidase
Important for autoinhibition of adenylyltransferase activity
Restriction system protein Mrr-like N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Thiol:disulfide interchange protein DsbD N-terminal
Thiol:disulfide interchange protein DsbD N-terminal domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Activator of Hsp90 ATPase homologue 1-like C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Polymerase/histidinol phosphatase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Cob(I)alamin adenosyltransferase N-terminal
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Methionyl-tRNA synthetase anticodon-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
DNA replication/recombination mediator RecO N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Putative Flp pilus-assembly TadG-like N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Moybdenum cofactor oxidoreductase dimerisation
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Membrane insertase YidC/Oxa/ALB C-terminal
Phosphodiester glycosidase domain-containing protein
ABC-type glycine betaine transport system substrate-binding
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
S-adenosylmethionine-dependent methyltransferase
Peptidase C14 caspase domain-containing protein
Na+/H+ antiporter MnhB subunit-related protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ionotropic glutamate receptor C-terminal
Alpha-glycerophosphate oxidase C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Thiamin pyrophosphokinase thiamin-binding
Beta-lactamase hydrolase-like protein phosphatase-like
Cytochrome c oxidase subunit IV bacterial aa3 type
Large ribosomal subunit protein uL15/eL18
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Pyruvate/ketoisovalerate oxidoreductase catalytic
ATP synthase F1 complex delta/epsilon subunit N-terminal
Proline utilization A proline dehydrogenase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Gamma-glutamylcyclotransferase AIG2-like
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cysteine sulfenic acid (-SOH) intermediate
Peptide methionine sulfoxide reductase MsrA
TAXI family TRAP transporter solute-binding subunit
Type II secretion system protein TadB-like N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aspartate/homoserine dehydrogenase NAD-binding
6-phosphogluconate dehydrogenase C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Thymidylate synthase/dCMP hydroxymethylase
Tat pathway signal sequence domain protein
Regulator of nucleoside diphosphate kinase N-terminal
Outer membrane protein assembly factor BamA
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Membrane fusion protein biotin-lipoyl like
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Major facilitator superfamily associated
DNA topoisomerase I catalytic core eukaryotic-type
PhoD-like phosphatase metallophosphatase
Outer membrane lipoprotein carrier protein LolA
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Exonuclease VII large subunit C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
D-galactarate/Altronate dehydratase C-terminal
ABC transporter substrate-binding protein
Required for zinc-mediated homotetramerization and catalytic activity
Pyrimidine nucleoside phosphorylase C-terminal
Caspase family p20 domain-containing protein
Guanylate kinase/L-type calcium channel beta subunit
Plays an important role in substrate specificity
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Release factor glutamine methyltransferase N-terminal
Glycosyl transferase family 3 N-terminal
Glycine zipper domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
N-end rule aminoacyl transferase C-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Phosphonate ABC transporter substrate-binding protein
Right handed beta helix domain-containing protein
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Superoxide dismutase copper/zinc binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Adaptive response protein AidB N-terminal
Anthranilate synthase component I N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
RNA binding; important for wobble base 34 recognition
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
General stress protein FMN-binding split barrel
Outer membrane protein beta-barrel domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
NADH:ubiquinone oxidoreductase 30kDa subunit
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH:ubiquinone oxidoreductase chain 4 N-terminal
HTH cro/C1-type domain-containing protein
Organic solvent tolerance-like N-terminal
Cobaltochelatase subunit CobS N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Phosphoribosylformylglycinamidine synthase linker
Ricin B lectin domain-containing protein
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Probable periplasmic serine endoprotease DegP-like
Acyl-CoA dehydrogenase N-terminal bacteria