TonB-dependent receptor-like beta-barrel
Alanyl-transfer RNA synthetases family profile
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Alpha-D-phosphohexomutase alpha/beta/alpha
RNA polymerase sigma factor 70 region 4 type 2
Glycosyltransferase subfamily 4-like N-terminal
Glycoside hydrolase family 31 N-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
3-keto-disaccharide hydrolase domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Beta-hexosaminidase bacterial type N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Major facilitator superfamily (MFS) profile
Cysteine sulfenic acid (-SOH) intermediate
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein bL9 C-terminal
Plays an important role in maintaining the position of the catalytic nucleophile
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Helix-hairpin-helix DNA-binding motif class 1
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Glycoside hydrolase family 42 N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Outer membrane lipoprotein-sorting protein
Aminoacyl-transfer RNA synthetases class-II family profile
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
SUF system FeS cluster assembly SufBD N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Thiamine pyrophosphate enzyme TPP-binding
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ATP-dependent DNA helicase RecG C-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribosome maturation factor RimP N-terminal
RNA 2-O ribose methyltransferase substrate binding
Quercetin 2,3-dioxygenase C-terminal cupin
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Right handed beta helix domain-containing protein
Phosphodiester glycosidase domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Positions MEP for the nucleophilic attack
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glycine cleavage T-protein C-terminal barrel
Thymidylate synthase/dCMP hydroxymethylase
Carboxypeptidase-like regulatory domain-containing protein
Organic solvent tolerance-like N-terminal
Anthranilate synthase component I N-terminal
Glycoside hydrolase family 57 N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
O-(5'-phospho-DNA)-tyrosine intermediate
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
S-adenosyl-L-homocysteine hydrolase NAD binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
ATPsynthase alpha/beta subunit N-terminal extension
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Shikimate dehydrogenase substrate binding N-terminal
Tryptophan synthase beta chain-like PALP
Cyclophilin-like domain-containing protein
Polysaccharide chain length determinant N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphoadenosine phosphosulphate reductase
Peptidase S9 prolyl oligopeptidase catalytic
Outer membrane protein beta-barrel domain-containing protein
Cation-transporting P-type ATPase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Inosine/uridine-preferring nucleoside hydrolase
DNA replication/recombination mediator RecO N-terminal
Type III restriction/modification enzyme methylation subunit
HicB-like antitoxin of toxin-antitoxin system
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Arginine decarboxylase C-terminal helical
Erythronate-4-phosphate dehydrogenase dimerisation
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Putative beta-lactamase-inhibitor-like PepSY-like
Putative beta-lactamase-inhibitor-like PepSY-like domain-containing protein
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Glycosyl hydrolase-like 10 domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Aconitase A/isopropylmalate dehydratase small subunit swivel
Reversibly protonated during proton transport
Polymerase/histidinol phosphatase N-terminal
Glycosyl hydrolase family 30 beta sandwich
O-(3'-phospho-DNA)-tyrosine intermediate
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Essential for prephenate dehydratase activity
Meso-diaminopimelate D-dehydrogenase C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glycosyl-hydrolase 97 C-terminal oligomerisation
Ribose-phosphate pyrophosphokinase N-terminal
Solute-binding protein family 3/N-terminal
Small ribosomal subunit protein uS4 N-terminal
Phosphomannose isomerase type I catalytic
ATP synthase F1 complex delta/epsilon subunit N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Exonuclease VII large subunit C-terminal
Putative auto-transporter adhesin head GIN
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Glycosyl transferase family 3 N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Trigger factor ribosome-binding bacterial
Putative auto-transporter adhesin head GIN domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Gliding motility-associated protein GldM C-terminal
Gliding motility-associated protein GldM N-terminal
Large ribosomal subunit protein uL15/eL18
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Prokaryotic-type class I peptide chain release factors
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Putative acyltransferase ACT14924-like acyltransferase
Surface glycan-binding protein B xyloglucan binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Polysaccharide biosynthesis protein CapD-like
Pseudouridine synthase I TruA alpha/beta
Schiff-base intermediate with substrate; via pyruvic acid
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Translation elongation factor P/YeiP central
Saccharopine dehydrogenase-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Membrane insertase YidC/Oxa/ALB C-terminal
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Sodium/calcium exchanger membrane region
Signal transduction histidine kinase internal region
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Could be important to modulate the pK values of the two catalytic cysteine residues
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Formamidopyrimidine-DNA glycosylase catalytic
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Bacterial transcription activator effector binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein uL2 C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
PhoPQ-activated pathogenicity-related protein
Large ribosomal subunit protein uL6 alpha-beta
Putative oxidoreductase/dehydrogenase Rossmann-like
Plays an important role in substrate specificity
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Secretion system C-terminal sorting domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
tRNA pseudouridylate synthase B C-terminal
Surface glycan-binding protein B xyloglucan binding domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Polysaccharide biosynthesis protein C-terminal
Phosphatidylglycerol lysyltransferase C-terminal
6-phosphogluconate dehydrogenase C-terminal
DNA mismatch repair proteins mutS family
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Penicillin-binding protein transpeptidase
Calcineurin-like phosphoesterase domain-containing protein
Glycoside hydrolase family 13 N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Integral membrane protein YccS N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
GxGYxYP putative glycoside hydrolase C-terminal
GxGYxYP putative glycoside hydrolase N-terminal
Chromosomal replication initiator DnaA C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Lysidine-tRNA(Ile) synthetase C-terminal
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Major fimbrial subunit protein N-terminal
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase