Major facilitator superfamily (MFS) profile
Phosphocysteine intermediate; for EIIB activity
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Involved in allosteric activation by GTP
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Copper amine oxidase-like N-terminal domain-containing protein
Could play a key role in the communication between the regulatory and the substrate sites
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
RNA polymerase sigma factor 70 region 4 type 2
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glycine cleavage T-protein C-terminal barrel
Small ribosomal subunit protein uS4 N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Solute-binding protein family 3/N-terminal
Butirosin biosynthesis protein H N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
6-phosphogluconate dehydrogenase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Molybdopterin cofactor biosynthesis C (MoaC)
Aminoacyl-transfer RNA synthetases class-II family profile
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Phosphotransferase system enzyme I N-terminal
Pesticidal crystal protein Cry22Aa Ig-like
Pesticidal crystal protein Cry22Aa Ig-like domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Peptidase S9 prolyl oligopeptidase catalytic
Fibronectin type-III domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Septum formation inhibitor MinC C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Polymerase/histidinol phosphatase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Transcriptional regulator SgrR N-terminal HTH
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Right handed beta helix domain-containing protein
SbsC C-terminal domain-containing protein
Pseudouridine synthase I TruA alpha/beta
Peptidase M14 carboxypeptidase A domain-containing protein
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyl hydrolase family 30 beta sandwich
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
S-adenosyl-L-homocysteine hydrolase NAD binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Periplasmic binding protein domain-containing protein
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Large ribosomal subunit protein uL2 C-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alanyl-transfer RNA synthetases family profile
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Transcription regulator AsnC/Lrp ligand binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Interaction with polymerase core subunit RpoC
Penicillin-binding protein transpeptidase
Amidohydrolase-related domain-containing protein
ABC transporter substrate-binding protein PnrA-like
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Na+-translocating membrane potential-generating system MpsC
Glycoside hydrolase family 31 N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Bacterial type II secretion system protein E
Alpha-D-phosphohexomutase alpha/beta/alpha
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Glycosyl hydrolase-like 10 domain-containing protein
Cell wall-active antibiotics response LiaF-like C-terminal
Large ribosomal subunit protein uL15/eL18
ABC transporter substrate-binding protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
PLD phosphodiesterase domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glycoside hydrolase family 42 N-terminal
Membrane fusion protein biotin-lipoyl like
Glycosyltransferase subfamily 4-like N-terminal
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
Flagellar hook-length control protein-like C-terminal
Phosphoribosylformylglycinamidine synthase linker
Signal recognition particle SRP54 helical bundle
Flagellar Assembly Protein A N-terminal region
Phosphatidylglycerol lysyltransferase C-terminal
Anthranilate synthase component I N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
CobB/CobQ-like glutamine amidotransferase
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Sodium/calcium exchanger membrane region
Lysidine-tRNA(Ile) synthetase C-terminal
Flagellar motor switch protein FliN-like C-terminal
Beta-lactamase-related domain-containing protein
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Glucose/Sorbosone dehydrogenase domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyl transferase family 3 N-terminal
Fe/B12 periplasmic-binding domain-containing protein
NIF system FeS cluster assembly NifU C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
tRNA pseudouridylate synthase B C-terminal
Alpha galactosidase C-terminal beta sandwich
Anti-bacteriophage protein A/HamA C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein uL6 alpha-beta
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Glycoamylase-like domain-containing protein
Ionotropic glutamate receptor C-terminal
Putative regulatory protein FmdB Zinc ribbon
Plays an important role in substrate specificity
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Schiff-base intermediate with D-ribose 5-phosphate
May play a role in transmitting local conformational changes
Pyridine nucleotide-disulphide oxidoreductase dimerisation
ABC-type uncharacterised transport system
Bulb-type lectin domain-containing protein
Reversibly protonated during proton transport
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Glyoxalase/fosfomycin resistance/dioxygenase
Gly-cisPro motif, important for rejection of L-amino acids
Exonuclease VII large subunit C-terminal
NIF system FeS cluster assembly NifU N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Peptide methionine sulphoxide reductase MsrA
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Cell envelope-related transcriptional attenuator
S-adenosylmethionine-dependent methyltransferase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Tryptophan RNA-binding attenuator protein
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Microcin J25-processing protein McjB C-terminal
DNA-directed DNA polymerase family A palm
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Thymidylate synthase/dCMP hydroxymethylase
Translation elongation factor P/YeiP central
Prepilin type IV endopeptidase peptidase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Tryptophan synthase beta chain-like PALP
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Polysaccharide biosynthesis protein C-terminal
DNA replication/recombination mediator RecO N-terminal
Magnesium transporter MgtE intracellular
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Schiff-base intermediate with acetaldehyde
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cobalamin-independent methionine synthase MetE N-terminal
DnaJ homologue subfamily C member 28 conserved
Peptidase C-terminal archaeal/bacterial domain-containing protein
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Carbamoyl-phosphate synthase small subunit N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Heme-copper oxidase subunit III family profile
General stress protein FMN-binding split barrel
Gram-positive cocci surface proteins LPxTG domain-containing protein
Integron-associated effector binding protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Type II secretion system protein GspE N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Formamidopyrimidine-DNA glycosylase catalytic
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Superoxide dismutase copper/zinc binding
Phosphomannose isomerase type I catalytic
Putative aromatic acid exporter C-terminal
Peptidase S8/S53 domain-containing protein
Cellulose-binding Sde182 nucleoside hydrolase-like
Cellulose-binding Sde182 nucleoside hydrolase-like domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Asl1-like glycosyl hydrolase catalytic domain-containing protein
Release factor glutamine methyltransferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Threonine/serine exporter-like N-terminal
Resolvase/invertase-type recombinase catalytic
Important for interaction with partner proteins
Gp5/Type VI secretion system Vgr protein OB-fold
Sporulation transcription regulator WhiA N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Thiamin pyrophosphokinase thiamin-binding
Glutathionylspermidine synthase pre-ATP-grasp-like
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Dienelactone hydrolase domain-containing protein
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Polysaccharide chain length determinant N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Essential for prephenate dehydratase activity
Mannose-6-phosphate isomerase type II C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycosyltransferase family 28 N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
ABC-type glycine betaine transport system substrate-binding
RNA binding; important for wobble base 34 recognition
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Positions MEP for the nucleophilic attack
Pyrimidine nucleoside phosphorylase C-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Ricin B lectin domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Cation-transporting P-type ATPase N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal