2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
TonB-dependent receptor-like beta-barrel
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Autotransporter domain-containing protein
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Mandelate racemase/muconate lactonizing enzyme C-terminal
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Amidohydrolase 3 domain-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
Major facilitator superfamily (MFS) profile
Transposase IS116/IS110/IS902 C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glucose-methanol-choline oxidoreductase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Pyruvate phosphate dikinase AMP/ATP-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
DNA replication/recombination mediator RecO N-terminal
Plays an important role in substrate specificity
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
O-(3'-phospho-DNA)-tyrosine intermediate
Aminoacyl-transfer RNA synthetases class-II family profile
Heavy-metal-associated domain-containing protein
Biopterin-dependent aromatic amino acid hydroxylase family profile
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Prokaryotic-type class I peptide chain release factors
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Organic solvent tolerance-like N-terminal
Histidine phosphotransferase ChpT C-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Flagellar basal-body/hook protein C-terminal
Tryptophan synthase beta chain-like PALP
Resolvase/invertase-type recombinase catalytic
Flagellar basal body rod protein N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Peptidase M20 dimerisation domain-containing protein
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Polymerase/histidinol phosphatase N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Penicillin-binding protein transpeptidase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Quercetin 2,3-dioxygenase C-terminal cupin
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
S-adenosylmethionine-dependent methyltransferase
Poly-beta-hydroxybutyrate polymerase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Glycosyltransferase subfamily 4-like N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Type I restriction modification DNA specificity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Interaction with polymerase core subunit RpoC
Magnesium chelatase subunit H N-terminal
Electron transfer via tryptophanyl radical
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Essential for prephenate dehydratase activity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Small ribosomal subunit protein uS4 N-terminal
Alginate export domain-containing protein
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Peptidase M1 membrane alanine aminopeptidase
Gamma-glutamylcyclotransferase AIG2-like
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Prepilin type IV endopeptidase peptidase
Magnesium transporter MgtE intracellular
Rap1a immunity protein domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Flagellar motor switch protein FliN-like C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Polypeptide-transport-associated ShlB-type
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
N-end rule aminoacyl transferase C-terminal
Sialate O-acetylesterase domain-containing protein
Membrane fusion protein biotin-lipoyl like
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Neutral/alkaline non-lysosomal ceramidase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Cytochrome c-type biogenesis protein CcmE
Peptidase S8/S53 domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Photosynthetic reaction centre H subunit N-terminal
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Right handed beta helix domain-containing protein
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Outer membrane protein assembly factor BamD
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Large ribosomal subunit protein uL6 alpha-beta
P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
TonB-dependent receptor-like beta-barrel domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
General stress protein FMN-binding split barrel
Cobaltochelatase subunit CobS N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Carbamoyl-phosphate synthase small subunit N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Required for zinc-mediated homotetramerization and catalytic activity
CagE TrbE VirB component of type IV transporter system central
Large ribosomal subunit protein uL2 C-terminal
Probable periplasmic serine endoprotease DegP-like
Peptide methionine sulfoxide reductase MsrA
RNA binding; important for wobble base 34 recognition
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Terminase large subunit gp17-like C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Flagellar hook-length control protein-like C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
PhoD-like phosphatase metallophosphatase
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Polysaccharide chain length determinant N-terminal
Glycosyl transferase family 3 N-terminal
Glycoside hydrolase family 42 N-terminal
PHA accumulation regulator DNA-binding N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose-methanol-choline oxidoreductase C-terminal
Large ribosomal subunit protein uL15/eL18
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Putative regulatory protein FmdB Zinc ribbon
HicB-like antitoxin of toxin-antitoxin system
DNA-directed DNA polymerase family A palm
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Reversibly protonated during proton transport
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Signal recognition particle SRP54 helical bundle
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Methionyl-tRNA synthetase anticodon-binding
RND efflux pump membrane fusion protein barrel-sandwich
Bacterial type II secretion system protein E
Molybdate ABC transporter substrate-binding protein
YbgF trimerisation domain-containing protein
Cytochrome oxidase subunit II copper A binding
Glycoside hydrolase GH146 substrate-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Important for beta-aspartyl-AMP intermediate formation
Restriction system protein Mrr-like N-terminal
Secretin/TonB short N-terminal domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Proline utilization A proline dehydrogenase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Pyridoxamine 5'-phosphate oxidase putative
Serine aminopeptidase S33 domain-containing protein
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Tetrahydrodipicolinate-N-succinyltransferase chain A
ATP synthase F1 complex delta/epsilon subunit N-terminal
Signal transduction histidine kinase internal region
Heme-copper oxidase subunit III family profile
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Transferrin-binding protein B C-lobe/N-lobe beta barrel domain-containing protein
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
S-adenosyl-L-homocysteine hydrolase NAD binding
Type II secretion system protein GspI C-terminal
Schiff-base intermediate with dihydroxyacetone-P
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Pseudouridine synthase I TruA alpha/beta
Histidine kinase/HSP90-like ATPase domain-containing protein
Ribose-phosphate pyrophosphokinase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Could be important to modulate the pK values of the two catalytic cysteine residues
Nitrogenase molybdenum-iron protein beta chain N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Proton acceptor; for glutaminase activity
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
3-keto-disaccharide hydrolase domain-containing protein
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Alpha-glycerophosphate oxidase C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
PEP-CTERM sorting domain-containing protein
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Alanyl-transfer RNA synthetases family profile
Exonuclease VII large subunit C-terminal
Phosphoribosylformylglycinamidine synthase linker
Translation elongation factor P/YeiP central
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alpha-D-phosphohexomutase alpha/beta/alpha
Magnesium-protoporphyrin IX methyltransferase C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Polysaccharide biosynthesis protein C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
YbaK/aminoacyl-tRNA synthetase-associated
Survival protein SurE-like phosphatase/nucleotidase
Glucosamine/galactosamine-6-phosphate isomerase
C-type lysozyme inhibitor domain-containing protein
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Heat-inducible transcription repressor HrcA C-terminal
DNA mismatch repair proteins mutS family
Ribosomal RNA adenine methylase transferase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Cytochrome c-type biogenesis protein CcmF C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cellulose-binding Sde182 nucleoside hydrolase-like
Cellulose-binding Sde182 nucleoside hydrolase-like domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Gp5/Type VI secretion system Vgr protein OB-fold
TonB C-terminal domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Anthranilate synthase component I N-terminal
Metallo-beta-lactamase domain-containing protein
ABC-type transport auxiliary lipoprotein component
Flagella basal body P-ring formation protein FlgA C-terminal
Flagella basal body P-ring formation protein FlgA C-terminal domain-containing protein
Histidine-specific methyltransferase SAM-dependent
Dinitrogenase iron-molybdenum cofactor biosynthesis
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Calcineurin-like phosphoesterase domain-containing protein
Type I restriction enzyme R protein N-terminal
Leucine-binding protein domain-containing protein
Superoxide dismutase copper/zinc binding
Alpha/beta hydrolase fold-3 domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Cytochrome b561 bacterial/Ni-hydrogenase