Heme-copper oxidase subunit III family profile
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Pseudouridine synthase I TruA alpha/beta
Polysaccharide biosynthesis protein CapD-like
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Signal recognition particle SRP54 helical bundle
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glycosyl hydrolase family 30 beta sandwich
Major facilitator superfamily (MFS) profile
RNA polymerase sigma factor 70 region 4 type 2
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Phosphotransferase system enzyme I N-terminal
Chromosomal replication initiator DnaA C-terminal
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Phosphoribosylformylglycinamidine synthase linker
Gly-cisPro motif, important for rejection of L-amino acids
Signal transduction histidine kinase internal region
Mannose-6-phosphate isomerase type II C-terminal
Solute-binding protein family 3/N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Thiamine pyrophosphate enzyme TPP-binding
5-glutamyl coenzyme A thioester intermediate
Cytochrome b/b6 N-terminal region profile
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
ABC transporter substrate-binding protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Cytochrome C biogenesis protein transmembrane
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Ribose-phosphate pyrophosphokinase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Sugar ABC transporter substrate-binding protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Cell envelope-related transcriptional attenuator
Glycosyltransferase subfamily 4-like N-terminal
Plays an important role in substrate specificity
Schiff-base intermediate with substrate; via pyruvic acid
Copper amine oxidase-like N-terminal domain-containing protein
Alanyl-transfer RNA synthetases family profile
Major facilitator superfamily associated
O-(3'-phospho-DNA)-tyrosine intermediate
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Dipicolinate synthase subunit A N-terminal
Interaction with polymerase core subunit RpoC
ABC transporter substrate-binding protein PnrA-like
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
General stress protein FMN-binding split barrel
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Beta-xylosidase C-terminal Concanavalin A-like
Right handed beta helix domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Polysaccharide biosynthesis protein C-terminal
DnaJ homologue subfamily C member 28 conserved
Could play a key role in the communication between the regulatory and the substrate sites
Phosphocysteine intermediate; for EIIB activity
RNA 2-O ribose methyltransferase substrate binding
Small ribosomal subunit protein uS4 N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Probable transposase IS891/IS1136/IS1341
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Glycoside hydrolase family 42 N-terminal
Bacterial type II secretion system protein E
Pyridoxamine 5'-phosphate oxidase putative
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glycosyl hydrolase-like 10 domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Essential for prephenate dehydratase activity
Large ribosomal subunit protein uL15/eL18
Phosphatidylglycerol lysyltransferase C-terminal
Prepilin type IV endopeptidase peptidase
Cysteine sulfenic acid (-SOH) intermediate
DNA mismatch repair proteins mutS family
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glycoside hydrolase family 31 N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Reversibly protonated during proton transport
NADH-rubredoxin oxidoreductase C-terminal
Glycine cleavage T-protein C-terminal barrel
Fibronectin type-III domain-containing protein
Anthranilate synthase component I N-terminal
Schiff-base intermediate with acetaldehyde
Transposase IS116/IS110/IS902 C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Penicillin-binding protein transpeptidase
Transcriptional regulator SgrR N-terminal HTH
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
SsuA/THI5-like domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Involved in allosteric activation by GTP
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyruvate phosphate dikinase AMP/ATP-binding
Polymerase/histidinol phosphatase N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Transcriptional regulator TetR C-terminal Firmicutes type
Butirosin biosynthesis protein H N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Exonuclease VII large subunit C-terminal
Lacto-N-biose phosphorylase-like N-terminal TIM barrel
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
YbbR-like domain-containing protein YbbR
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Membrane insertase YidC/Oxa/ALB C-terminal
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
O-(5'-phospho-DNA)-tyrosine intermediate
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Large ribosomal subunit protein bL12 C-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Signal transduction response regulator propionate catabolism activator N-terminal
Glycoside hydrolase GH146 substrate-binding
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Release factor glutamine methyltransferase N-terminal
Polysaccharide chain length determinant N-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Phosphomannose isomerase type I catalytic
Periplasmic binding protein domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Microcin J25-processing protein McjB C-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
SUF system FeS cluster assembly SufBD N-terminal
Bacterial transcription activator effector binding
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
DNA-directed DNA polymerase family A palm
3-keto-disaccharide hydrolase domain-containing protein
Glutathionylspermidine synthase pre-ATP-grasp-like
YbaK/aminoacyl-tRNA synthetase-associated
Ionotropic glutamate receptor C-terminal
Positions MEP for the nucleophilic attack
DNA-3-methyladenine glycosylase AlkA N-terminal
Important for beta-aspartyl-AMP intermediate formation
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Transcription regulator AsnC/Lrp ligand binding
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Important for interaction with partner proteins
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein bL12 oligomerization
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Protein-PII uridylyltransferase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
CD-NTase-associated protein 12/Pycsar effector protein TIR
Tryptophan synthase beta chain-like PALP
Dinitrogenase iron-molybdenum cofactor biosynthesis
Ferrous iron transport protein B C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Flagellar assembly protein FliH/Type III secretion system HrpE
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Flagellar Assembly Protein A N-terminal region
6-phosphogluconate dehydrogenase C-terminal
Putative aromatic acid exporter C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Could be important to modulate the pK values of the two catalytic cysteine residues
Quercetin 2,3-dioxygenase C-terminal cupin
Sorbitol phosphotransferase enzyme II C-terminal
Alpha galactosidase C-terminal beta sandwich
Polysaccharide lyase 8 N-terminal alpha-helical
Polysaccharide lyase family 8 C-terminal
Ribonucleotide reductase large subunit C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Choice-of-anchor A domain-containing protein
Glyoxalase/fosfomycin resistance/dioxygenase
RND efflux pump membrane fusion protein barrel-sandwich
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Flagellar motor switch protein FliN-like C-terminal
ABC-type glycine betaine transport system substrate-binding
Spore germination GerAC-like C-terminal domain-containing protein
Coagulation factor 5/8 type domain protein
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Sporulation stage IV protein A C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Cation-transporting P-type ATPase N-terminal
NIF system FeS cluster assembly NifU C-terminal
Saccharopine dehydrogenase-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Sporulation transcription regulator WhiA N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Proton acceptor; for glutaminase activity
RNA binding; important for wobble base 34 recognition
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Helix-hairpin-helix DNA-binding motif class 1
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Beta-hexosaminidase bacterial type N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
S-adenosylmethionine-dependent methyltransferase
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Peptidase M1 membrane alanine aminopeptidase
Cell wall hydrolase SleB domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
Sodium/calcium exchanger membrane region
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Nitrogenase molybdenum-iron protein beta chain N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Glycosyltransferase family 28 N-terminal
Methionyl-tRNA synthetase anticodon-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Beta-1,3-glucanase N-terminal domain-containing protein
Thymidylate synthase/dCMP hydroxymethylase
Sugar fermentation stimulation protein C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
NIF system FeS cluster assembly NifU N-terminal
Na+-translocating membrane potential-generating system MpsC
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Molybdopterin cofactor biosynthesis C (MoaC)
Polynucleotide kinase-phosphatase ligase
Protein O-mannosyl-transferase C-terminal four TM
Important for autoinhibition of adenylyltransferase activity
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Helix-hairpin-helix DNA-binding motif class 1 domain-containing protein
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Thiamin pyrophosphokinase thiamin-binding
Translation elongation factor P/YeiP central
Membrane iron-sulfur containing protein FtrD-like
Large ribosomal subunit protein bL9 C-terminal
Peptide methionine sulphoxide reductase MsrA
UDP-glucose/GDP-mannose dehydrogenase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose