Major facilitator superfamily (MFS) profile
Glycosyltransferase subfamily 4-like N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Transposase IS116/IS110/IS902 C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Tryptophan synthase beta chain-like PALP
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Phosphoadenosine phosphosulphate reductase
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
UDP N-acetylglucosamine O-acyltransferase C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL2 C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Helix-hairpin-helix DNA-binding motif class 1
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pyruvate dehydrogenase E1 component middle
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Cysteine sulfenic acid (-SOH) intermediate
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Polymerase/histidinol phosphatase N-terminal
Phosphocysteine intermediate; for EIIB activity
Shikimate dehydrogenase substrate binding N-terminal
Membrane iron-sulfur containing protein FtrD-like
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Involved in allosteric activation by GTP
Outer membrane protein assembly factor BamB
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Bacterial type II secretion system protein E
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glutathionylspermidine synthase pre-ATP-grasp-like
TonB-dependent receptor-like beta-barrel
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Outer-membrane lipoprotein carrier protein
Cation-transporting P-type ATPase N-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Ribose-phosphate pyrophosphokinase N-terminal
Essential for prephenate dehydratase activity
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Sodium/calcium exchanger membrane region
ABC-type transport auxiliary lipoprotein component
Could be important to modulate the pK values of the two catalytic cysteine residues
Tellurite resistance methyltransferase TehB-like
Positions MEP for the nucleophilic attack
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein uL15/eL18
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Translocation and assembly module subunit TamA
Nitrite/Sulfite reductase ferredoxin-like
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Flagellar motor switch protein FliN N-terminal
Flagellar motor switch protein FliN-like C-terminal
Arginine decarboxylase C-terminal helical
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Important for beta-aspartyl-AMP intermediate formation
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
4'-phosphopantetheinyl transferase N-terminal
Non-canonical purine NTP phosphatase/PRRC1
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
ABC-type glycine betaine transport system substrate-binding
D-galactose/methyl-galactoside binding periplasmic protein MglB
Alpha-D-phosphohexomutase alpha/beta/alpha
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
DNA polymerase III delta subunit C-terminal
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Essential for degradation by Lon protease
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Aminoacyl-transfer RNA synthetases class-II family profile
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Interacts with tRNA; defines subfamily-specific binding signature
Large ribosomal subunit protein bL25 L25
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
DNA polymerase III subunit delta C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Membrane fusion protein biotin-lipoyl like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
DnaJ homologue subfamily C member 28 conserved
Polysaccharide biosynthesis protein C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Flagella basal body P-ring formation protein FlgA
Prepilin type IV endopeptidase peptidase
Large ribosomal subunit protein uL6 alpha-beta
Translation elongation factor P/YeiP central
Nucleoside-specific channel-forming protein, Tsx
Polysaccharide chain length determinant N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Mandelate racemase/muconate lactonizing enzyme C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Signal transduction histidine kinase dimerisation/phosphoacceptor
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Aromatic amino acid beta-eliminating lyase/threonine aldolase
HicB-like antitoxin of toxin-antitoxin system
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Electron transfer via tryptophanyl radical
Twin-arginine translocation signal domain-containing protein
Penicillin-binding protein transpeptidase
Transcriptional regulator SgrR N-terminal HTH
Reversibly protonated during proton transport
YbaK/aminoacyl-tRNA synthetase-associated
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
O-(3'-phospho-DNA)-tyrosine intermediate
O-(5'-phospho-DNA)-tyrosine intermediate
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Prokaryotic-type class I peptide chain release factors
Peptidase S9 prolyl oligopeptidase catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
RNA methyltransferase SpoU/TrmH type C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Peptide methionine sulphoxide reductase MsrA
Organic solvent tolerance-like N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Regulator of nucleoside diphosphate kinase N-terminal
L-seryl-tRNA selenium transferase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
RNA polymerase sigma factor 70 region 4 type 2
N6 adenine-specific DNA methyltransferase N-terminal
Menaquinone biosynthesis protein MenD middle
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Penicillin-binding protein activator LpoB
Bacterial transcription activator effector binding
Transposon Tn7 transposition protein TnsD C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Hypersensitivity response secretion-like HrpJ
Type III secretion system effector delivery regulator TyeA
Phosphatidylinositol-specific phospholipase C X
Thymidylate synthase/dCMP hydroxymethylase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Copper-binding periplasmic metallochaperone CueP
Antitoxin Xre/MbcA/ParS-like toxin-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphotransferase system enzyme I N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Membrane-bound lytic murein transglycosylase C
Required for dimer formation and molybdate binding
Molybdopterin cofactor biosynthesis C (MoaC)
Polysaccharide biosynthesis protein CapD-like
Sugar fermentation stimulation protein C-terminal
Formate-dependent nitrite reductase complex subunit
SUF system FeS cluster assembly SufBD N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Alpha-glycerophosphate oxidase C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Chromosomal replication initiator DnaA C-terminal
Plays an important role in substrate specificity
Pseudouridine synthase I TruA alpha/beta
Ribosomal RNA adenine methylase transferase N-terminal
Major facilitator superfamily associated
Type III secretion system flagellar brake protein YcgR PilZN
Plays an important role in discriminating NADH against NADPH
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Integral membrane protein YccS N-terminal
High-affinity zinc uptake system protein ZnuA
Schiff-base intermediate with acetaldehyde
Ion-translocating oxidoreductase complex subunit G
RNA 2-O ribose methyltransferase substrate binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glycoside hydrolase family 31 N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Gamma-glutamylcyclotransferase AIG2-like
Important for interaction with partner proteins
Nucleophile; cysteine thiosulfonate intermediate
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Phosphatidic acid phosphatase type 2/haloperoxidase
Cytochrome b561 bacterial/Ni-hydrogenase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Schiff-base intermediate with substrate; via pyruvic acid
Glycine cleavage T-protein C-terminal barrel
DNA-directed DNA polymerase family A palm
Pyrimidine nucleoside phosphorylase C-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Pyruvate phosphate dikinase AMP/ATP-binding
Signal transduction histidine kinase 5TM receptor LytS transmembrane region
Signal transduction histidine kinase internal region
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Penicillin-binding protein activator LpoA
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Thiol:disulfide interchange protein DsbD
Appears to be important in orienting the phosphate for catalysis
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Survival protein SurE-like phosphatase/nucleotidase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Heme-copper oxidase subunit III family profile
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Chitobiase/beta-hexosaminidases N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Disulphide bond isomerase DsbC/G N-terminal
Exonuclease VII large subunit C-terminal
Alanyl-transfer RNA synthetases family profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Tetrahydrodipicolinate-N-succinyltransferase chain A
Superoxide dismutase copper/zinc binding
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Terminase large subunit-like endonuclease
Important for substrate binding and specificity
Carbamoyl-phosphate synthase small subunit N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Outer membrane protein assembly factor BamE
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Release factor glutamine methyltransferase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Glycosyl transferase family 3 N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
For 3-hydroxyacyl-CoA dehydrogenase activity
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Lipopolysaccharide export system protein LptA