Aminoacyl-transfer RNA synthetases class-II family profile
Phosphatidic acid phosphatase type 2/haloperoxidase
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Alpha-D-phosphohexomutase alpha/beta/alpha
Lacto-N-biose phosphorylase-like N-terminal TIM barrel
Phosphocysteine intermediate; for EIIB activity
Major facilitator superfamily (MFS) profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glycoside hydrolase family 31 N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cell division protein FtsQ/DivIB C-terminal
Polymerase/histidinol phosphatase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Periplasmic binding protein domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Large ribosomal subunit protein uL2 C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
O-(3'-phospho-DNA)-tyrosine intermediate
Helix-hairpin-helix DNA-binding motif class 1
Penicillin-binding protein transpeptidase
RNA binding; important for wobble base 34 recognition
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Ribose-phosphate pyrophosphokinase N-terminal
Glycosyl transferase family 3 N-terminal
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL6 alpha-beta
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Gram-positive pilin backbone subunit 2 Cna-B-like
Alanyl-transfer RNA synthetases family profile
Important for autoinhibition of adenylyltransferase activity
S-adenosyl-L-homocysteine hydrolase NAD binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Release factor glutamine methyltransferase N-terminal
Glycoside hydrolase family 42 N-terminal
Beta-hexosaminidase bacterial type N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Thiamin pyrophosphokinase thiamin-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Tryptophan synthase beta chain-like PALP
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
ATP-dependent DNA helicase RecG C-terminal
Gram-positive cocci surface proteins LPxTG
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ionotropic glutamate receptor C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Pesticidal crystal protein Cry22Aa Ig-like
Type I restriction modification DNA specificity
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Proton acceptor; for glutaminase activity
ATP synthase F1 complex delta/epsilon subunit N-terminal
Small ribosomal subunit protein uS4 N-terminal
Phosphotransferase system enzyme I N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Glucosamine/galactosamine-6-phosphate isomerase
RNA polymerase sigma factor 70 region 4 type 2
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Shikimate dehydrogenase substrate binding N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Prepilin type IV endopeptidase peptidase
Glycosyltransferase subfamily 4-like N-terminal
Cyclophilin-like domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Phosphoribosylformylglycinamidine synthase linker
Glycosyl hydrolase family 30 beta sandwich
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Anthranilate synthase component I N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Large ribosomal subunit protein uL15/eL18
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Ribosomal RNA small subunit methyltransferase E methyltransferase
Peptidase M1 membrane alanine aminopeptidase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Cation-transporting P-type ATPase N-terminal
ABC-type glycine betaine transport system substrate-binding
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Transcriptional regulator LacI/GalR-like sensor
Transcription regulator AsnC/Lrp ligand binding
Galactose-1-phosphate uridyl transferase C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Choloylglycine hydrolase/NAAA C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Translation elongation factor P/YeiP central
Essential for prephenate dehydratase activity
Sporulation transcription regulator WhiA N-terminal
Membrane iron-sulfur containing protein FtrD-like
DNA replication/recombination mediator RecO N-terminal
Plays an important role in substrate specificity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
NIF system FeS cluster assembly NifU N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Positions MEP for the nucleophilic attack
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
N6 adenine-specific DNA methyltransferase N-terminal
Interaction with polymerase core subunit RpoC
NAD(P) transhydrogenase alpha subunit C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
6-phosphogluconate dehydrogenase C-terminal
Putative regulatory protein FmdB Zinc ribbon
LPXTG-motif cell wall anchor domain-containing protein
Signal recognition particle SRP54 helical bundle
Schiff-base intermediate with D-ribose 5-phosphate
Membrane insertase YidC/Oxa/ALB C-terminal
Cell envelope-related transcriptional attenuator
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Chromosomal replication initiator DnaA C-terminal
Pseudouridine synthase I TruA alpha/beta
CobB/CobQ-like glutamine amidotransferase
DNA-directed DNA polymerase family A palm
Galactose-1-phosphate uridyl transferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Phosphatidate phosphatase APP1 catalytic
Reversibly protonated during proton transport
Peptidase S9 prolyl oligopeptidase catalytic