Pyridine nucleotide-disulphide oxidoreductase dimerisation
Activator of Hsp90 ATPase homologue 1-like C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Schiff-base intermediate with substrate; via pyruvic acid
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Solute-binding protein family 3/N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Inosine/uridine-preferring nucleoside hydrolase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-104)
Peptidase S8/S53 domain-containing protein
RNA 2-O ribose methyltransferase substrate binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Tryptophan synthase beta chain-like PALP
Tat pathway signal sequence domain protein
Aminoacyl-transfer RNA synthetases class-II family profile
Allene oxide cyclase barrel-like domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
Proton acceptor; for glutaminase activity
Important for beta-aspartyl-AMP intermediate formation
Glycosyl transferase family 3 N-terminal
Penicillin-binding protein transpeptidase
SGNH hydrolase-type esterase domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
ABC-type glycine betaine transport system substrate-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Formamidopyrimidine-DNA glycosylase catalytic
Bulb-type lectin domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Major facilitator superfamily (MFS) profile
Gfo/Idh/MocA-like oxidoreductase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Ribosome maturation factor RimP N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Gamma-glutamylcyclotransferase AIG2-like
Phosphatidic acid phosphatase type 2/haloperoxidase
Schiff-base intermediate with dihydroxyacetone-P
AFL C-terminal domain-containing protein
Coagulation factor 5/8 type domain-containing protein
Lipoprotein LpqB beta-propeller domain-containing protein
Cell envelope-related transcriptional attenuator
Polymerase/histidinol phosphatase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Heme-copper oxidase subunit III family profile
Gram-positive cocci surface proteins LPxTG domain-containing protein
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
DNA primase/polymerase bifunctional N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Bacterial bifunctional deaminase-reductase C-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Large ribosomal subunit protein uL6 alpha-beta
3-beta hydroxysteroid dehydrogenase/isomerase
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Glycosyltransferase subfamily 4-like N-terminal
Leucine-binding protein domain-containing protein
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Butirosin biosynthesis protein H N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
MucB/RseB N-terminal domain-containing protein
Ricin B lectin domain-containing protein
Glucose-methanol-choline oxidoreductase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Beta-hexosaminidase bacterial type N-terminal
RlpA-like protein double-psi beta-barrel
SUF system FeS cluster assembly SufBD N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Large ribosomal subunit protein uL2 C-terminal
Histidine-specific methyltransferase SAM-dependent
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Phosphoribosylformylglycinamidine synthase linker
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycosyltransferase family 28 N-terminal
Anti-sigma-D factor RsdA sigma factor binding region
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
CobB/CobQ-like glutamine amidotransferase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Photosynthesis system II assembly factor Ycf48/Hcf136-like
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Alpha-D-phosphohexomutase alpha/beta/alpha
Thiamine pyrophosphate enzyme TPP-binding
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Exonuclease VII large subunit C-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Phosphocysteine intermediate; for EIIB activity
Pyruvate phosphate dikinase AMP/ATP-binding
Heat-inducible transcription repressor HrcA C-terminal
PhoD-like phosphatase metallophosphatase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Endonuclease/exonuclease/phosphatase domain-containing protein
Glucose-methanol-choline oxidoreductase C-terminal
Translation elongation factor P/YeiP central
Efflux RND transporter periplasmic adaptor subunit
Peptidase M14 carboxypeptidase A domain-containing protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Phosphomannose isomerase type I catalytic
Peptidase S1A alpha-lytic prodomain domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Cellulase Ig-like domain-containing protein
Periplasmic binding protein domain-containing protein
Anthranilate synthase component I N-terminal
Solute-binding protein family 5 domain-containing protein
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Glyoxalase/fosfomycin resistance/dioxygenase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Right handed beta helix domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Ionotropic glutamate receptor C-terminal
Peptidase C39-like domain-containing protein
Alpha-L-arabinofuranosidase B arabinose-binding
Helix-hairpin-helix DNA-binding motif class 1
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
DNA replication/recombination mediator RecO N-terminal
6-phosphogluconate dehydrogenase C-terminal
LamG-like jellyroll fold domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Alpha-carbonic anhydrase domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
Phosphoadenosine phosphosulphate reductase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Transcriptional regulator LacI/GalR-like sensor
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
AB hydrolase-1 domain-containing protein
Transcription regulator AsnC/Lrp ligand binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
HTH-type transcriptional regulator AraC-type N-terminal
Electron transfer via tryptophanyl radical
Lactate utilization protein B C-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cytochrome b/b6 N-terminal region profile
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Nucleophile; cysteine thiosulfonate intermediate
Rhamnogalacturonan I lyase beta-sheet domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Thymidylate synthase/dCMP hydroxymethylase
Glucose/Sorbosone dehydrogenase domain-containing protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Septum formation-related domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Large ribosomal subunit protein uL15/eL18
Putative regulatory protein FmdB Zinc ribbon
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Nitrite/Sulfite reductase ferredoxin-like
Myo-inositol-1-phosphate synthase GAPDH-like
Peptidase M1 membrane alanine aminopeptidase
DnaJ homologue subfamily C member 28 conserved
Glycoside-hydrolase family GH114 TIM-barrel
Glycoside-hydrolase family GH114 TIM-barrel domain-containing protein
Sodium/calcium exchanger membrane region
ABC transporter substrate-binding protein
Periplasmic copper-binding protein NosD beta helix
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Gp5/Type VI secretion system Vgr protein OB-fold
Lipocalin-like domain-containing protein
O-(3'-phospho-DNA)-tyrosine intermediate
NADH-rubredoxin oxidoreductase C-terminal
Prepilin type IV endopeptidase peptidase
Plays an important role in substrate specificity
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Removed in mature form; by autocatalysis
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Interaction with polymerase core subunit RpoC
NIF system FeS cluster assembly NifU N-terminal
Anaphase-promoting complex subunit 4-like WD40
4'-phosphopantetheinyl transferase N-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
PsrA tetracyclin repressor-like C-terminal
Pyruvate dehydrogenase E1 component middle
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
SsuA/THI5-like domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Pyrroline-5-carboxylate reductase dimerisation
6-phosphogluconate dehydrogenase NADP-binding
Subtilisin inhibitor domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Glycosyl transferase family 28 C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Peptidoglycan recognition protein family
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
NADH:ubiquinone oxidoreductase 30kDa subunit
Essential for prephenate dehydratase activity
Cytochrome C biogenesis protein transmembrane
Superoxide dismutase copper/zinc binding
Superoxide dismutase copper/zinc binding domain-containing protein
Glyoxalase-like domain-containing protein
Positions MEP for the nucleophilic attack
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycine cleavage T-protein C-terminal barrel
Chitin-binding type-3 domain-containing protein
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Squalene cyclase C-terminal domain-containing protein
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
vWA-MoxR associated protein middle region 2
RlpA-like protein double-psi beta-barrel domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Beta-lactamase-related domain-containing protein
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
2,4-diaminopentanoate dehydrogenase C-terminal
Chromosomal replication initiator DnaA C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA-directed DNA polymerase family A palm
Aconitase A/isopropylmalate dehydratase small subunit swivel
Peptidase M12B domain-containing protein
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Alpha-1,6-glucosidases pullulanase-type C-terminal
Glycoside hydrolase family 13 N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Flagellar hook-length control protein FliK
Transposase IS116/IS110/IS902 C-terminal
Mandelate racemase/muconate lactonizing enzyme N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Transition state stabilizer; via amide nitrogen
Schiff-base intermediate with D-ribose 5-phosphate
N,N-dimethylformamidase beta subunit-like C-terminal
Heavy metal-binding domain-containing protein
Release factor glutamine methyltransferase N-terminal
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Erythromycin biosynthesis protein CIII-like central
Adaptive response protein AidB N-terminal
Peptidoglycan binding-like domain-containing protein
Putative oxidoreductase/dehydrogenase Rossmann-like
Shikimate dehydrogenase substrate binding N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
ABC transporter substrate-binding protein PnrA-like
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Prokaryotic-type class I peptide chain release factors
Bacterial type II secretion system protein E
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
N6 adenine-specific DNA methyltransferase N-terminal
Methionyl-tRNA synthetase anticodon-binding
DNA topoisomerase I catalytic core eukaryotic-type
Alanyl-transfer RNA synthetases family profile
Glycoside hydrolase family 42 N-terminal
Phosphotransferase system enzyme I N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Quinolinate phosphoribosyl transferase N-terminal
AraC-type transcription regulator ligand-binding
Important for autoinhibition of adenylyltransferase activity
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
NAD(P) transhydrogenase alpha subunit C-terminal
Actinobacteria/chloroflexi VLRF1 release factor
Sugar ABC transporter substrate-binding protein
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
TetR transcriptional regulator CgmR-like C-terminal
Adenylyl/Guanylyl and SMODS C-terminal sensor
Reversibly protonated during proton transport
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes